Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-24T23:55:21.789Z Has data issue: false hasContentIssue false
  • English
  • Français

Spherical indentation of lungs: Experiments, modeling and sub-surface imaging

Published online by Cambridge University Press:  31 January 2011

Maricris R. Silva ,
Zhijia Yuan ,
Jae Hun Kim ,
Zhenguo Wang ,
Melissa Hoyos ,
Yingtian Pan  and
Andrew Gouldstone
Maricris R. Silva
Affiliation:
Department of Mechanical and Industrial Engineering, Northeastern University, Boston, Massachusetts 02199
Zhijia Yuan
Affiliation:
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794
Jae Hun Kim
Affiliation:
Department of Materials Science and Engineering, Stony Brook University, Stony Brook, New York 11794
Zhenguo Wang
Affiliation:
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794
Melissa Hoyos
Affiliation:
Department of Materials Science and Engineering, Stony Brook University, Stony Brook, New York 11794
Yingtian Pan
Affiliation:
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794
Andrew Gouldstone*
Affiliation:
Department of Mechanical and Industrial Engineering, Northeastern University, Boston, Massachusetts 02199
*
b) Address all correspondence to this author. e-mail: [email protected]
Get access

Abstract

Knowledge of mechanics in atelectasis (alveolar collapse) and reinflation would be useful during anesthesia and critical care. Here an investigation is presented in which atelectasis is induced in a controlled manner on excised inflated lungs using spherical indentation, and noninvasive imaging of the deformed subsurface region is performed using optical coherence tomography (OCT). Indentation loads are physiologic, and spatial dimensions are far larger than alveolar size to allow continuum discussions. Experimental observations of atelectasis are compared with finite element model calculations of maximum stresses. Finally, atelectasis is compared during inflation of lungs with different gases (e.g., air, oxygen/anesthesia mixture).

Keywords

BiologicalHardnessOptical
Type
Articles
Information
Journal of Materials Research , Volume 24 , Issue 3 , March 2009 , pp. 1156 - 1166
Copyright
Copyright © Materials Research Society 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Udobi, K.F., Childs, E., and Touijer, K.: Acute respiratory-distre syndrome. Am. Fam. Physician 67, 315 (2003).Google Scholar
2.Sarnaik, A.P., Daphtary, K.M., Meert, K.L., Lieh-Lai, M.W., and Heidemann, S.M.: Pressure-controlled ventilation in children with severe status asthmaticus. Pediatr. Crit. Care Med. 5, 133 (2004).Google Scholar
3.Dreyfuss, D. and Saumon, G.: Ventilator-induced lung injury—Lessons from experimental studies. Am. J. Respir. Crit. Care Med. 157, 294 (1998).Google Scholar
4.Duggan, M. and Kavanagh, B.P.: Pulmonary atelectasis-A pathogenic perioperative entity. Anesthesioloev 102, 838 (2005).CrossRefGoogle Scholar
5.Magnusson, L. and Spahn, D.R.: New concepts of atelectasis during general anaesthesia. Br. J. Anaesth. 91, 61 (2003).Google Scholar
6.West, J.B.: Respiratory Physiology—The Essentials, 6th ed. (Williams Lippincott & Wilkins, Philadelphia, PA, 2000).Google Scholar
7.Lai-Fook, S.J., Wilson, T.A., Hyatt, R.E., and Rodarte, J.R.: Elastic constants of inflated lobes of dog lungs. J. Appl. Physiol. 40, 508 (1976).Google Scholar
8.Hajji, M.A.: Indentation of a membrane on an elastic half space. J. Appl. Mech. Trans. ASME 45, 320 (1978).CrossRefGoogle Scholar
9.Hajji, M.A., Wilson, T.A., and Lai-Fook, S.J.: Improved measurements of shear modulus and pleural membrane tension of the lung. J. Appl. Physiol. 47, 175 (1979).Google Scholar
10.Johnson, K.: Contact Mechanics (Cambridge University Press, New York, 1985).Google Scholar
11.Ashino, Y., Ying, X., Dobbs, L.G., and Bhattacharya, J.: [Ca2+]i oscillations regulate type II cell exocytosis in the pulmonary alveolus. Am. J. Physiol. Lung Cell. Mol. Physiol. 279, L5 (2000).Google Scholar
12.Aoshiba, K., Yokohori, N., and Nagai, A.: Alveolar wall apoptosis causes lung destruction and emphysematous changes. Am. J. Respir. Cell Mol. Biol. 28, 555 (2003).CrossRefGoogle ScholarPubMed
13.Vlahakis, N.E., Schroeder, M.A., Pagano, R.E., and Hubmayr, R.D.: Deformation-induced lipid trafficking in alveolar epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 280, L938 (2001).Google Scholar
14.Hanna, N., Saltzman, D., Mukai, D., Chen, Z., Sasse, S., Milliken, J., Guo, S., Jung, W., Colt, H., and Brenner, M.: Two-dimensional and з-dimensional optical coherence tomographic imaging of the airway, lung, and pleura. J. Thorac. Cardiovasc. Surg. 129, 615 (2005).Google Scholar
15.Huang, D., Swanson, E.A., Lin, C.P., Schuman, J.S., Stinson, W.G., Chang, W., Hee, M.R., Flotte, T., Gregory, K., Puliafito, C.A., and Fujimoto, J.G.: Optical coherence tomography. Science 254, 1178 (1991).Google Scholar
16.Popp, A., Wendel, M., Knells, L., Koch, T., and Koch, E.: Imaging of the three-dimensional alveolar structure and the alveolar mechanics of a ventilated and perfused isolated rabbit lung with Fourier domain optical coherence tomography. J. Biomed. Opt. 11, 014015 (2006).Google Scholar
17.Stamenovic, D.: Mechanical-properties of pleural membrane. J. Appl. Physiol. 57, 1189 (1984).Google Scholar
18.Gouldstone, A., Brown, R.E., Butler, J.P., and Loring, S.H.: Stiffness of the pleural surface of the chest wall is similar to that of lung. J. Appl. Physiol. 95, 2345 (2003).CrossRefGoogle Scholar
19.Kim, J.H. and Gouldstone, A.: Spherical indentation of a membrane on elastic half space. J. Mater. Res. 23(8), 2212 (2008).Google Scholar
20.Ugural, A.C.: Stresses in Plates and Shells, 2nd ed. (WCB/ McGraw Hill, Boston, 1999).Google Scholar
21.Smith, J.C. and Stamenovic, D.: Surface forces in lungs—Alveolar surface tension-lung volume relationships. J. Appl. Physiol. 60, 1341 (1986).Google Scholar
22.Zuo, Y.Y., Veldhuizen, R.A.W., Neumann, A.W., Petersen, N.O., and Possmayer, F.: Current perspectives in pulmonary surfactant-Inhibition, enhancement and evaluation. Biochim. Biophys. Acta 1778, 1947 (2008).Google Scholar
23.Bourbon, J.R.: Pulmonary Surfactant–Biochemical, Functional, Regulatory, and Clinical Concepts, 1st ed. (CRC Press, New York, 1991).Google Scholar
24.Hoppin, F.G. Jr, Stothert, J.C. Jr, Greaves, I.A., Lai, Y-L., and Hildebrandt, J.: Lung recoil: Elastic and rheological properties, in Handbook of Physiology: The Respiratory System, sec. 3, vol. III, pt. I, chap. 13, edited by Fishman, A.P. (Am. Physiol. Soc., Bethesda, MD, 1986), pp. 195–215.Google Scholar
25.Cavagna, A., Stemmler, E.J., and DuBois, A.B.: Alveolar resistance to atelectasis. J. Appl. Physiol. 22, 441 (1967).CrossRefGoogle ScholarPubMed
26.Ruiz, P. and Chartrand, D.: The effect of isoflurane 0.6% on respiratory mechanics in anesthetized-paralyzed humans is not increased at concentrations of 0.9% and 1.2%. Can. J. Anaesth. 50, 67 (2003).Google Scholar
27.Sato, J., Shinozuka, N., Kochi, A., Uchida, H., and Mizuguchi, T.: Low-dose halothane produces airway dilatation but does not alter parenchymal mechanics in the normal canine lung. Can. J. Anaesth. 42, 438 (1995).Google Scholar