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Hydrolytic stability and biocompatibility on smooth muscle cells of polyethylene glycol–polycaprolactone-based polyurethanes

Published online by Cambridge University Press:  12 November 2020

Maria Morales-Gonzalez ,
Said Arévalo-Alquichire ,
Luis E. Diaz ,
Juan Ángel Sans ,
Guillermo Vilariño-Feltrer ,
José A. Gómez-Tejedor  and
Manuel F. Valero
Maria Morales-Gonzalez
Affiliation:
Process Design and Management, Faculty of Engineering, Universidad de La Sabana, Chía140013, Colombia Energy, Materials and Environment Group, Faculty of Engineering, Universidad de La Sabana, Chía140013, Colombia
Said Arévalo-Alquichire
Affiliation:
Energy, Materials and Environment Group, Faculty of Engineering, Universidad de La Sabana, Chía140013, Colombia
Luis E. Diaz
Affiliation:
Bioprospecting Research Group, Faculty of Engineering, Universidad de La Sabana, Chía140013, Colombia
Juan Ángel Sans
Affiliation:
Instituto de Diseño para la Fabricación y Producción Automatizada, MALTA Consolider, Universitat Politècnica de València, Valencia46022, Spain
Guillermo Vilariño-Feltrer
Affiliation:
Centre for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia46022, Spain
José A. Gómez-Tejedor
Affiliation:
Centre for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia46022, Spain Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Valencia46022, Spain
Manuel F. Valero*
Affiliation:
Energy, Materials and Environment Group, Faculty of Engineering, Universidad de La Sabana, Chía140013, Colombia
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

Interactions between smooth muscle cells (SMCs) and biomaterials must not result in phenotype changes as this may generate uncontrolled multiplication processes and occlusions in vascular grafts. The aim of this study was to relate the hydrolytic stability and biocompatibility of polyurethanes (PUs) on SMCs. A higher polycaprolactone (PCL) concentration was found to improve the hydrolytic stability of the material and the adhesion of SMCs. A material with 5% polyethylene glycol, 90% PCL, and 5% pentaerythritol presented high cell viability and adhesion, suggesting a contractile phenotype in SMCs depending on the morphology. Nevertheless, all PUs retained their elastic modulus over 120 days, similar to the collagen of native arteries (~10 MPa). Furthermore, aortic SMCs did not present toxicity (viability over 80%) and demonstrated adherence without any abnormal cell multiplication processes, which is ideal for the function to be fulfiled in situ in the vascular grafts.

Keywords

biomaterialbiomedical
Type
Article
Information
Journal of Materials Research , Volume 35 , Issue 23-24 , 14 December 2020 , pp. 3276 - 3285
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Copyright
Copyright © The Author(s), 2020, published on behalf of Materials Research Society by Cambridge University Press

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