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The control of morphological and size properties of carbamazepine-imprinted microspheres and nanospheres under different synthesis conditions

Published online by Cambridge University Press:  27 September 2013

Mehdi Esfandyari-Manesh ,
Mehran Javanbakht ,
Elnaz Shahmoradi ,
Rassoul Dinarvand  and
Fatemeh Atyabi
Mehdi Esfandyari-Manesh*
Affiliation:
Department of Chemistry, Amirkabir University of Technology, Tehran, Iran; and Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Mehran Javanbakht
Affiliation:
Department of Chemistry, Amirkabir University of Technology, Tehran, Iran; and Nano Science and Technology Research Center, Amirkabir University of Technology, Tehran, Iran
Elnaz Shahmoradi
Affiliation:
Department of Chemical Engineering, Sharif University of Technology, Tehran, Iran
Rassoul Dinarvand
Affiliation:
Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Fatemeh Atyabi
Affiliation:
Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

Potential applications of the molecularly imprinted polymers (MIPs) demand physical configurations in different size ranges. Nowadays, research on MIPs is focused on the development of new or improved morphologies, which involves control and modification of the different parameters during the synthesis. In this study, the effect of different synthesis conditions on the particle size and morphology is investigated. Carbamazepine-imprinted polymers were prepared using precipitation polymerization under various conditions such as: the amounts of cross-linker and functional monomers, initiator, porogen, temperature and time of polymerization. We studied the polymerization conditions to obtain imprinted spherical particles with controllable sizes in the range of 243 nm to 3.4 μm. Scanning electron microscopy and photon correlation spectroscopy were utilized to investigate the morphological characterization. The mole ratio of the functional monomer to the cross-linker was important to obtain smaller uniformly sized particles. In addition, the results showed that the cross-linker in the molecular imprinting synthesis can affect the morphology and composition of the MIPs, which influences the binding affinity.

Keywords

molecular imprintingprecipitation polymerizationsynthesis conditionsnanospheremorphology
Type
Articles
Information
Journal of Materials Research , Volume 28 , Issue 19 , 14 October 2013 , pp. 2677 - 2686
Copyright
Copyright © Materials Research Society 2013 

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References

REFERENCES

Haupt, K. and Mosbach, K.: Molecularly imprinted polymers and their use in biomimetic sensors. Chem. Rev. 100, 2495 (2000).CrossRefGoogle ScholarPubMed
Sekine, S., Watanabe, Y., Yoshimi, Y., Hattori, K., and Sakai, K.: Influence of solvents on chiral discriminative gate effect of molecularly imprinted poly(ethylene glycol dimethacrylate-co-methacrylic acid). Sens. Actuators, B 127, 512 (2007).CrossRefGoogle Scholar
Richter, A., Gibson, U.J., Nowicki, M., and BelBruno, J.J.: Processing and morphology of molecularly imprinted nylon thin films. J. Appl. Polym. Sci. 101, 2919 (2006).CrossRefGoogle Scholar
Haginaka, J., Tabo, H., and Kagawa, C.: Uniformly sized molecularly imprinted polymers for d-chlorpheniramine: Influence of a porogen on their morphology and enantioselectivity. J. Pharm. Biomed. Anal. 46, 877 (2008).CrossRefGoogle ScholarPubMed
Yoshimatsu, K., Reimhult, K., Krozer, A., Mosbach, K., Sode, K., and Ye, L.: Uniform molecularly imprinted microspheres and nanoparticles prepared by precipitation polymerization: The control of particle size suitable for different analytical applications. Anal. Chim. Acta 584, 112 (2007).CrossRefGoogle ScholarPubMed
Liang, S., Wan, J., Zhu, J., and Cao, X.: Effects of porogens on the morphology and enantioselectivity of core-shell molecularly imprinted polymers with ursodeoxycholic acid. Sep. Purif. Technol. 72, 208 (2010).CrossRefGoogle Scholar
Wei, S. and Mizaikoff, B.: Binding site characteristics of 17B-estradiol imprinted polymers. Biosens. Bioelectron. 23, 201 (2007).CrossRefGoogle Scholar
Chaitidou, S., Kotrotsiou, O., Kotti, K., Kammona, O., Bukhari, M., and Kiparissides, C.: Precipitation polymerization for the synthesis of nanostructured particles. Mater. Sci. Eng., B. 152, 55 (2008).CrossRefGoogle Scholar
Pérez-Moral, N. and Mayes, A.G.: Comparative study of imprinted polymer particles prepared by different polymerisation methods. Anal. Chim. Acta 504, 15 (2004).CrossRefGoogle Scholar
Holland, N., Frisby, J., Owens, E., Hughes, H., Duggan, P., and McLoughlin, P.: The influence of polymer morphology on the performance of molecularly imprinted polymers. Polymer 51, 1578 (2010).CrossRefGoogle Scholar
Vaihinger, D., Landfester, K., Krauter, I., Brunner, H., and Tovar, G.E.M.: Molecularly imprinted polymer nanospheres as synthetic affinity receptors obtained by miniemulsion polymerisation. Macromol. Chem. Phys. 203, 1965 (2002).3.0.CO;2-C>CrossRefGoogle Scholar
Esfandyari-Manesh, M., Javanbakht, M., Atyabi, F., Mohammadi, A., Mohammadi, S., Akbari-Adergani, B., and Dinarvand, R.: Dipyridamole recognition and controlled release by uniformly sized molecularly imprinted nanospheres. Mater. Sci. Eng., C 31, 1692 (2011).CrossRefGoogle Scholar
Javanbakht, M., Mohammadi, S., Esfandyari-Manesh, M., and Abdouss, M.: Molecularly imprinted polymer microspheres with nano-pore cavities prepared by precipitation polymerization as new carriers for the sustained release of dipyridamole. J. Appl. Polym. Sci. 119, 1586 (2011).CrossRefGoogle Scholar
Esfandyari-Manesh, M., Javanbakht, M., Dinarvand, R., and Atyabi, F.: Molecularly imprinted nanoparticles prepared by miniemulsion polymerization as selective receptors and new carriers for the sustained release of carbamazepine. J. Mater. Sci. - Mater. Med. 23, 963 (2012).CrossRefGoogle ScholarPubMed
Javanbakht, M., Fard, S.E., Mohammadi, A., Abdouss, M., Ganjali, M.R., Norouzi, P., and Safaraliee, L.: Molecularly imprinted polymer based potentiometric sensor for the determination of hydroxyzine in tablets and biological fluids. Anal. Chim. Acta 612, 65 (2008).CrossRefGoogle ScholarPubMed
Javanbakht, M., Fard, S.E., Abdouss, M., Mohammadi, A., Ganjali, M.R., Norouzi, P., and Safaraliee, L.: A biomimetic potentiometric sensor using molecularly imprinted polymer for the cetirizine assay in tablets and biological fluids. Electroanalysis 20, 2023 (2008).CrossRefGoogle Scholar
Javanbakht, M., Attaran, A.M., Namjumanesh, M.H., Esfandyari-Manesh, M., and Akbari-adergani, B.: Solid-phase extraction of tramadol from plasma and urine samples using a novel water-compatible molecularly imprinted polymer. J. Chromatogr. B 878, 1700 (2010).CrossRefGoogle ScholarPubMed
Tunc, Y., Hasirci, N., Yesilada, A., and Ulubayram, K.: Comonomer effects on binding performances and morphology of acrylate-based imprinted polymers. Polymer 47, 6931 (2006).CrossRefGoogle Scholar
Cormack, P.A.G. and Elorz, A.Z.: Molecularly imprinted polymers: Synthesis and characterization. J. Chromatogr. B 804, 173 (2004).CrossRefGoogle Scholar
Esfandyari-Manesh, M., Javanbakht, M., Atyabi, F., and Dinarvand, R.: Synthesis and evaluation of uniformly sized carbamazepine-imprinted microspheres and nanospheres prepared with different mole ratios of methacrylic acid to methyl methacrylate for analytical and biomedical applications. J. Appl. Polym. Sci. 125, 1804 (2012).CrossRefGoogle Scholar
Pich, A. and Richtering, W.: Advances in Polymer Science (Springer, Germany, 2010).Google Scholar
Ciardelli, G., Cioni, B., Cristallini, C., Barbani, N., Silvestri, D., and Giusti, P.: Acrylic polymeric nanospheres for the release and recognition of molecules of clinical interest. Biosens. Bioelectron. 20, 1083 (2004).CrossRefGoogle ScholarPubMed
Spivak, D.A.: Optimization, evaluation, and characterization of molecularly imprinted polymers. Adv. Drug Delivery Rev. 57, 1779 (2005).CrossRefGoogle ScholarPubMed
Ye, L. and Mosbach, K.: Molecularly imprinted microspheres as antibody binding mimics. React. Funct. Polym. 48, 149 (2001).CrossRefGoogle Scholar
Esfandyari-Manesh, M., Javanbakht, M., Atyabi, F., Badiei, A., and Dinarvand, R.: Effect of porogenic solvent on the morphology, recognition and release properties of carbamazepine-molecularly imprinted polymer nanospheres. J. Appl. Polym. Sci. 121, 1118 (2011).CrossRefGoogle Scholar
Piletsky, S.A., Piletska, E.V., Karim, K., Freebairn, K.W., Legge, C.H., and Turner, A.P.F.: Polymer cookery: Influence of polymerization conditions on the performance of molecularly imprinted polymers. Macromolecules 35, 7499 (2002).CrossRefGoogle Scholar
Piletsky, S.A., Mijangos, I., Guerreiro, A., Piletska, E.V., Chianella, I., Karim, K., and Turner, A.P.F.: Polymer cookery: Influence of polymerization time and different initiation conditions on performance of molecularly imprinted polymers. Macromolecules 38, 1410 (2005).CrossRefGoogle Scholar