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Blend-based fibers produced via centrifugal spinning and electrospinning processes: Physical and rheological properties

Published online by Cambridge University Press:  11 August 2020

Nathália O. Muniz Open the ORCID record for Nathália O. Muniz [Opens in a new window] ,
Fernanda A. Vechietti ,
Guilherme R. Anesi ,
Gustavo V. Guinea  and
Luís Alberto L. dos Santos
Nathália O. Muniz*
Affiliation:
Laboratory of Biomaterials, Materials Engineering Department, Federal University of Rio Grande do Sul – UFRGS, Porto Alegre/RS90650-001, Brazil Center for Biomedical Technology, Universidad Politécnica de Madrid (UPM), Campus Montegancedo, Pozuelo de Alarcón, Madrid28223, Spain
Fernanda A. Vechietti
Affiliation:
Laboratory of Biomaterials, Materials Engineering Department, Federal University of Rio Grande do Sul – UFRGS, Porto Alegre/RS90650-001, Brazil Mechanics and Composite Materials Department, Leibniz-Institut für Polymerforschung, Dresden01069, Germany
Guilherme R. Anesi
Affiliation:
Laboratory of Biomaterials, Materials Engineering Department, Federal University of Rio Grande do Sul – UFRGS, Porto Alegre/RS90650-001, Brazil
Gustavo V. Guinea
Affiliation:
Center for Biomedical Technology, Universidad Politécnica de Madrid (UPM), Campus Montegancedo, Pozuelo de Alarcón, Madrid28223, Spain
Luís Alberto L. dos Santos
Affiliation:
Laboratory of Biomaterials, Materials Engineering Department, Federal University of Rio Grande do Sul – UFRGS, Porto Alegre/RS90650-001, Brazil
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

Cellprene™ is a recently developed polymeric blend based on poly(lactide-co-glycolide) (PLGA)/polyisoprene (PI) with good biological performance for biomedical applications. However, its potential as fiber scaffold in tissue engineering is still unknown, and the influence of processing parameters is yet to be understood. In this study, several compositions based on PLGA/PI blend mixed with hydroxyapatite (HAp) and polyethylene glycol (PEG) were prepared by solvent casting. Then, the membranes were used to produce micro/nanofibers by centrifugal spinning (CS) and electrospinning (ES). The viscosity's effect was studied to find an ideal viscosity value to produce homogeneous micro/nanofibers. The in vitro bioactivity test was also performed. Rheological results showed that the best viscosity range was (0.105 Pa s > η > 0.138 Pa s) for CS; larger fibers of ES were produced with lower viscosities. The sample with the lowest HAp concentration exhibited thinner and more homogeneous non-beaded fibers and proved its bioactivity response.

Keywords

fiberblendbiomaterial
Type
Article
Information
Journal of Materials Research , Volume 35 , Issue 21 , 16 November 2020 , pp. 2905 - 2916
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Copyright © The Author(s), 2020, published on behalf of Materials Research Society by Cambridge University Press

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