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Adhesion and interfacial fracture in drug-eluting stents

Published online by Cambridge University Press:  31 January 2011

Juan Meng ,
Argjenta Orana ,
Ting Tan ,
Kurt Wolf ,
Nima Rahbar ,
Hannah Li ,
George Papandreou ,
Cynthia Maryanoff  and
Wole Soboyejo
Juan Meng
Affiliation:
Princeton Institute of Science and Technology of Materials, and the Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey 08544
Argjenta Orana
Affiliation:
Cordis Corporation, A Johnson and Johnson Company, Spring House, Pennsylvania 19446
Ting Tan
Affiliation:
Princeton Institute of Science and Technology of Materials, and the Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey 08544
Kurt Wolf
Affiliation:
Cordis Corporation, A Johnson and Johnson Company, Spring House, Pennsylvania 19446
Nima Rahbar
Affiliation:
Department of Civil and Environmental Engineering, University of Massachusetts–Dartmouth, North Dartmouth, Massachusetts 02747
George Papandreou
Affiliation:
Cordis Corporation, A Johnson and Johnson Company, Warren, New Jersey 07059
Cynthia Maryanoff
Affiliation:
Cordis Corporation, A Johnson and Johnson Company, Spring House, Pennsylvania 19446
Wole Soboyejo*
Affiliation:
Princeton Institute of Science and Technology of Materials, and the Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey 08544
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

This paper presents experimental and theoretical studies of the adhesion between the drug-eluting layer and a Parylene C primer layer in coatings present on a model drug-eluting stent. To quantify adhesion, Brazil nut sandwich specimens were prepared mimicking the layers of this coating. These samples were stressed to fracture, and the resulting initial cracks at the Parylene C/drug interface were used to measure the dependence of interfacial fracture energy of mode mixity. The mating fracture surfaces were then analyzed using scanning electron microscopy (SEM) and energy dispersive x-ray spectroscopy (EDX). The interfacial energy release rates were obtained over a wide variety of mode mixities. Adhesion and fracture mechanics models were then used to estimate the mode mixity dependency of interfacial fracture toughness. Fracture toughness was found to be larger under higher mode mixity than that under lower mixity and the analytical model showed close agreement with experimental results.

Keywords

AdhesionFractureCoating
Type
Articles
Information
Journal of Materials Research , Volume 25 , Issue 4 , April 2010 , pp. 641 - 647
Copyright
Copyright © Materials Research Society 2010

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References

REFERENCES

1.Hunter, W.L.Drug-eluting stents: Beyond the hyperbole. Adv. Drug Delivery Rev. 58, (3)347 (2006)CrossRefGoogle ScholarPubMed
2.Serruys, P.W., Kutryk, M.J.B., Ong, A.T.L.Coronary-artery stents. N. Engl. J. Med. 354, (5)483 (2006)CrossRefGoogle ScholarPubMed
3.Curfman, G.D., Morrissey, S., Jarcho, J.A., Drazen, J.M.Drug-eluting coronary stents—Promise and uncertainty. N. Engl. J. Med. 356, 1059 (2007)CrossRefGoogle ScholarPubMed
4.Ratner, B.D., Hoffman, A.S., Schoen, F.J., Lemons, J.E.Biomaterial Science: An Introduction to Materials in Medicine (Academic Press, Orlando, FL 1996)Google Scholar
5.Lewis, A.L., Furze, J.D., Small, S., Robertson, J.D., Higgins, B.J., Taylor, S., Ricci, D.R.Long-term stability of a coronary stent coating post-implanation. J. Biomed. Mater. Res. 63, 699 (2002)CrossRefGoogle Scholar
6.Wolf, K., Zong, Z., Meng, J., Orana, A., Rahbar, N., Balss, K.M., Papandreou, G., Maryanoff, C.A., Soboyejo, W.An investigation of adhesion in drug-eluting stent layers. J. Biomed. Mater. Res. Part A 87, (1)272 (2008)CrossRefGoogle ScholarPubMed
7.Rahbar, N., Wolf, K., Orana, A., Fennimore, R., Zong, Z., Meng, J., Papandreou, G., Maryanoff, C., Soboyejo, W.Adhesion and interfacial fracture toughness between hard and soft materials. J. Appl. Phys. 104, 103533 (2008)CrossRefGoogle Scholar
8.Wang, J.S., Suo, Z.Experimental determination of interfacial toughness curves using Brazil-nut-sandwiches. Acta Metall. Mater. 38, (7)1279 (1990)CrossRefGoogle Scholar
9.Atkinson, C., Smelser, R.E., Sanchez, J.Combined mode fracture via the cracked Brazilian disk test. Int. J. Fract. 18, (4)279 (1982)CrossRefGoogle Scholar
10.Suo, Z., Hutchinson, J.W.Sandwich test specimens for measuring interface crack toughness. Mater. Sci. Eng., A 107, 135 (1989)CrossRefGoogle Scholar
11.Klugherz, B.D., Llanos, G., Lieullen, W., Kopia, G.A., Papandreou, G., Narayan, P., Sasseen, B., Adelman, S.J., Falotico, R., Wilensky, R.L.Twenty-eight-day efficacy and phamacokinetics of the sirolimus-eluting stent. Coron. Artery Dis. 13, 183 (2002)CrossRefGoogle ScholarPubMed
12.Johnson, K.L., Kendal, K., Roberts, A.D.Surface energy and the contact of elastic solids. Proc. R. Soc. London, Ser. A 324, (1558)301 (1971)Google Scholar
13.Carpick, R.W., Ogletree, D.F., Salmeron, M.A general equation for fitting contact area and friction vs load measurements. J. Colloid Interface Sci. 211, (2)395 (1999)CrossRefGoogle ScholarPubMed
14.Derjaguin, B.V., Muller, V.M., Toporov, Y.P.Effect of contact deformations on the adhesion of particles. J. Colloid Interface Sci. 53, 314 (1975)CrossRefGoogle Scholar
15.Maugis, D.Adhesion of spheres: The JKR-DMT transition using a dugdale model. J. Colloid Interface Sci. 150, (1)243 (1992)CrossRefGoogle Scholar
16.Venkatesh, R.Mechanical properties of alumina fiber glass matrix composites with and without a tin dioxide interface. Mater. Sci. Eng., A 268, (1–2)47 (1999)CrossRefGoogle Scholar
17.Evans, A.G., Hutchinson, J.W.Effects of non-planarity on the mixed-mode fracture resistence of bimaterial interfaces. Acta Metall. 37, 909 (1989)CrossRefGoogle Scholar
18.Budiansky, B., Amazigo, J.C., Evans, A.G.Small-scale crack bridging and the fracture toughness of particulate-reinforced ceramics. J. Mech. Phys. Solids 36, (2)167 (1988)CrossRefGoogle Scholar
19.Wise, D.L.Encyclopedic Handbook of Biomaterials and Bioengineering (Marcel Dekker, New York 1995)Google Scholar