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A Genomically Informed Education System? Challenges for Behavioral Genetics

Published online by Cambridge University Press:  01 January 2021

Abstract

The exponential growth of genetic knowledge and precision medicine research raises hopes for improved prevention, diagnosis, and treatment options for children with behavioral and psychiatric conditions. Although well-intended, this prospect also raise the possibility — and concern — that behavioral, including psychiatric genetic data would be increasingly used — or misused — outside the clinical context, such as educational settings. Indeed, there are ongoing calls to endorse a “personalized education” model that would tailor educational interventions to children's behavioral and psychiatric genetic makeup. This article explores the justifications for, and prospects and pitfalls of such endeavors. It considers the scientific challenges and highlights the ethical, legal, and social issues that will likely arise should behavioral genetic data become available (or be perceived as such) and are routinely incorporated in student education records. These include: when to disclose students' behavioral and psychiatric genetic profile; whose genomic privacy is protected and by whom; and how students' genetic data may affect education-related decisions. I argue that the introduction of behavioral genetics in schools may overshadow the need to address underlying structural and environmental factors that increase the risk for psychiatric conditions of all students, and that the unregulated use of student behavioral genetic profiles may lead to unintended consequences that are detrimental for individuals, families and communities. Relevant stakeholders — from parents and students to health professionals, educators, and policy-makers — ought to consider these issues before we forge ahead with a genomically informed education system.

Type
Independent Articles
Copyright
Copyright © American Society of Law, Medicine and Ethics 2018

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References

Grigorenko, E.L., “How Can Genomics Inform Education?,” Mind, Brain and Education 1, no. 1 (2007): 2027; C. Reilly, J. Senior, and L.A. Murtagh, “A Comparative Study of Educational Provision for Children with Neurogenetic Syndromes: Parent and Teacher Survey,” Journal of Intellectual Disability Ressearch 59, no. 12 (2015): 1094-1107.CrossRefGoogle Scholar
Grigorenko, supra note 1, at 22, 23.Google Scholar
Wold, S.J., “School Health Services: History and Trends,” in Schwab, N.C. and Gelfman, M.H.B., eds., Legal Issues in School Health Services: A Resource for School Administrators, Schools Attorneys, School Nurses (New York: Authors Choice Press; 2005): 754, at 7-8.Google Scholar
Culp-Ressler, T., “Three students got kicked out of an Arkansas public school because they might be HIV-positive,” Think Progress, 2016, available at <https://thinkprogress.org/three-students-got-kicked-out-of-an-arkansas-public-school-because-they-might-be-hiv-positive-502f27f8bff5/> (last accessed Sep. 25, 2017); AIDS Law Project of Pennsylvania, Milton Hershey School case: A student's fight against HIV discrimination, available at <http://www.aidslawpa.org/2012/06/abraham-smith-and-mother-smith-v-milton-hershey-school/2012> (last accessed Sep. 25, 2017).Google Scholar
Ryan, J., Virani, A., and Austin, J.C., “Ethical Issues Associated with Genetic Counseling in the Context of Adolescent Psychiatry,” Applied and Translational Genomic 5 (2015):2329, at 24.CrossRefGoogle Scholar
Dunn, E. C. et al., “Genetic Determinants of Depression: Recent Findings and Future Directions,” Harvard Review of Psychiatry 23, no. 1 (2015): 118, at 12-13.Google Scholar
American Academy of Pediatrics, “Ethical and Policy Issues in Genetic Testing and Screening of Children,” Pediatrics 131, no. 3 (2013): 620622, at 620.CrossRefGoogle Scholar
Knoppers, B.M. et al., “Whole-genome Sequencing in Newborn Screening Programs,” Science Translational Medicine 6, no. 229 (2014): 229cm222, at 1.CrossRefGoogle Scholar
Moeschler, J. B., “Medical Genetics Diagnostic Evaluation of the Child with Global Developmental Delay or Intellectual Disability,” Current Opinion in Neurology 21, no. 2 (2008):117122, at 118; R. E. Duncan, “An International Survey of Predictive Genetic Testing in Children for Adult Onset Conditions, “Genetics in Medicine 7, no. 6 (2005): 390-396, at 392.CrossRefGoogle Scholar
Connolly, J. J., Hakonarson, H., “The Impact of Genomics on Pediatric Research and Medicine,” Pediatrics 129, no. 6 (2012):11501160; B. L. Levenseller et al., “Stakeholders' Opinions on the Implementation of Pediatric Whole Exome Sequencing: Implications for Informed Consent,” Journal of Genetic Counseling 23, no. 4 (2014): 552-565; G. E. Henderson et al., “Characterizing Biobank Organizations in the U.S.: Results from a National Survey,” Genome Medicine 5, no. 1 (2013): 1-12 at 9.CrossRefGoogle Scholar
For a comprehensive discussion on the ethical, legal and social challenges arising from the participation of children, especially adolescents in genomic research and the return of genomic results to them see, Sabatello, M. and Appelbaum, P. S., “Raising Genomic Citizens: Adolescents and the Return of Secondary Genomic Findings,” Journal of Law, Medicine & Ethics 44, no. 2 (2016): 292308.CrossRefGoogle Scholar
Robertson, J. A., “Extending Preimplantation Genetic Diagnosis: The Ethical Debate. Ethical Issues in New Uses of Preim-plantation Genetic Diagnosis, Human Reproducation 18, no. 3 (2003): 465471.CrossRefGoogle Scholar
Franasiak, J. and Scott, R. T., “A Brief History of Preim-plantation Genetic Diagnosis and Preimplantation Genetic Screening,” (2008), available at <http://www.ivf-worldwide.com/cogen/oep/pgd-pgs/history-of-pgd-and-pgs.html> (last accessed Sep. 25, 2017).Google Scholar
Craven, L. et al., “Research into Policy: A Brief History of Mitochondrial Donation,” Stem Cells 34, no. 2 (2016): 265267.CrossRefGoogle Scholar
National Academies of Sciences Engineering and Medicine, Mitochondrial Replacement Techniques: Ethical, Social, and Policy Considerations (Washington, DC: National Academies Press, 2016): at 106108.Google Scholar
National Academies of Sciences Engineering and Medicine, Human Genome Editing: Science, Ethics, and Governance (Washington, DC: National Academies Press, 2017): at 136137.Google Scholar
Wilde, A. et al., “Implications of the Use of Genetic Tests in Psychiatry, with a Focus on Major Depressive Disorder: A Review,” Depression and Anxiety 30, no. 3 (2013): 267275, at 269-270.Google Scholar
23andMe, “Compare Our DNA Tests,” available at <https://www.23andme.com/compare-dna-tests/> (last accessed Sep. 25, 2017).+(last+accessed+Sep.+25,+2017).>Google Scholar
FDA, “FDA allows marketing of first direct-to-consumer tests that provide genetic risk information for certain conditions,” April 6, 2017, available at <https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm551185.htm> (last accessed Sep. 25, 2017).+(last+accessed+Sep.+25,+2017).>Google Scholar
Tercyak, K. P. et al., “Parents' Attitudes Toward Pediatric Genetic Testing for Common Disease Risk,” Pediatrics 127, no. 5 (2011): e12881295, at e1292-e1293.CrossRefGoogle Scholar
Lawrence, R. E. and Appelbaum, P. S., “Genetic Testing in Psychiatry: A Review of Attitudes and Beliefs,” Psychiatry 74, no. 4 (2011): 315331 at 323-324; J. A. Erickson et al., “Genetic Testing of Children for Predisposition to Mood Disorders: Anticipating the Clinical Issues,” Journal of Genetic Counseling 23, no. 4 (2014): 566-577, at 570-572, 574.Google Scholar
Duncan, L. E., Keller, M. C., “A Critical Review of the First 10 years of Candidate Gene-by Environment Interaction Research in Psychiatry,” American Journal of Psychiatry 168, no. 10 (2011): 10411049, at 1047-1048; L. E. Duncan, A. R. Pollastri, J. W. Smoller, “Mind the Gap: Why Many Geneticists and Psychological Scientists Have Discrepant Views about Gene-Environment Interaction (GxE) Research,” American Psychologist 69, no. 3 (2014): 249-268, at 254-255, 261.Google Scholar
Denno, D. W., “Courts' Increasing Consideration of Behavioral Genetics Evidence in Criminal Cases: Results of a Longitudinal Study,” Michigan State Law Review 2011, no. 3 (2011): 9671047; D. W. Denno, “Behavioral Genetics Evidence in Criminal Cases: 1994-2007,” in N.A. Farahany, ed., The Impact of Behavioral Sciences on Criminal Law (New York: Oxford Press, 2009): at 317-354, 465-398; F. Forzano et al., “Italian Appeal Court: A Genetic Predisposition to Commit Murder?” European Journal of Human Genetics 18, no. 5 (2010):519-521; S. McSwiggan, B. Elger, and P. S. Appelbaum, “The Forensic Use of Behavioral Genetics in Criminal Proceedings: Case of the MAOA-L Genotype,” International Journal of Law and Psychiatry 5 (2017): 17-23.Google Scholar
Plonit v. The Attorney General. Court case number 3-14, Feb. 9, 2015, District Court Tel Aviv-Jaffa (Hebrew), available at <http://www.psakdin.co.il/Court/598126#.VZqVPOseXdm> (last accessed Sep. 27, 2017); M. Sabatello and P. S. Appelbaum, “Behavioral Genetics in Criminal and Civil Courts,” Harvard Review of Psychiatry 25, no. 6 (2017): 289-301.+(last+accessed+Sep.+27,+2017);+M.+Sabatello+and+P.+S.+Appelbaum,+“Behavioral+Genetics+in+Criminal+and+Civil+Courts,”+Harvard+Review+of+Psychiatry+25,+no.+6+(2017):+289-301.>Google Scholar
Adacsi v Amin, Docket 1201-0330-AC, 2013 ABCA 315. Ct. App. Alberta, Canada; 2013.Google Scholar
Rothstein, M. A. and Rothstein, L., “How Genetics Might Affect Real Property Rights: Currents in Contemporary Bio-ethics,” Journal of Law, Medicine & Ethics 44, no. 1 (2016): 216221.Google Scholar
Ptak, C. and Petronis, A., “Epigenetic Approaches to Psychiatric Disorders,” Dialogues in Clinical Neuroscience 12, no. 1 (2010): 2535.Google Scholar
GlobeNewswire, GWG Life becomes first insurtech firm to collect epigenetic samples to analyze biomarkers of life insurance policy owners, available at <https://globenewswire.com/news-release/2017/03/02/930557/0/en/GWG-Life-Becomes-First-Insurtech-Firm-to-Collect-Epigenetic-Samples-to-Analyze-Biomarkers-of-Life-Insurance-Policy-Owners.html> (last accessed Sep. 25, 2017).+(last+accessed+Sep.+25,+2017).>Google Scholar
Collins, F. S., “Francis Collins Says Medicine in the Future will be Tailored to Your Genes; the Director of the National Institutes of Health Says Cheaper DNA Sequencing will Make Personalized Care Routine,” Wall Street Journal, July 7, 2014, available at <https://www.wsj.com/articles/francis-collins-says-medicine-in-the-future-will-be-tailored-to-your-genes-1404763139> (last accessed February 28, 2018).Google Scholar
Collins, F. S. et al., “A Vision for the Future of Genomics research,” Nature 422, no. 6934 (2003): 835847, at 841.CrossRefGoogle Scholar
Gason, A. A. et al., “It's ‘Back to School’ for Genetic Screening,” Europen Journal of Human Genetics 14, no. 4 (2006): 384389, at 385-386.Google Scholar
Id.; Ross, L. F., “Heterozygote Carrier Testing in High Schools Abroad: What Are the Lessons for the U.S.?” Journal of Law, Medicine & Ethics 34, no. 4 (2006):753764, at 753-755, 757-758.CrossRefGoogle Scholar
Gason et al., supra note 32, at 385.Google Scholar
Delatycki, M. B. et al., “Implementation of IronXS: A study of the Acceptability and Feasibility of Genetic Screening for Hereditary Hemochromatosis in High Schools,” Clinical Genetics 77, no. 3 (2010): 241248, at 241.CrossRefGoogle Scholar
Delatycki, M. B. et al., “IronXS: High-School Screening for Hereditary Haemochromatosis is Acceptable and Feasible,” European Journal of Human Genetics 20, no. 5 (2012): 505509, at 508.CrossRefGoogle Scholar
Salari, K. et al., “Evidence that Personal Genome Testing Enhances Student Learning in a Course on Genomics and Personalized Medicine,” PLoS One 8, no. 7 (2013): e68853; S. C. Sanderson et al., “How Do Students React to Analyzing their Own Genomes in a Whole-genome Sequencing Course?: Outcomes of a Longitudinal Cohort Study,” Genetics in Medicine 17, no. 11 (2015): 866-874.CrossRefGoogle Scholar
Park, M., “NCAA Genetic Screening Rule Sparks Discrimination Concerns,” August 4, 2010, available at <http://www.cnn.com/2010/HEALTH/08/04/ncaa.sickle.genetic.screening/> (last accessed Sep. 25, 2017).Google Scholar
ACSM and NCAA Joint Statement on Sickle Cell Trait and Exercise, Aug 23, 2013, available at <http://www.ncaa.org/health-and-safety/medical-conditions/acsm-and-ncaa-joint-statement-sickle-cell-trait-and-exercise-0> (last accessed Sep. 25, 2017).+(last+accessed+Sep.+25,+2017).>Google Scholar
Lewin, T., “College Bound, DNA Swab in Hand,” New York Times, May 18, 2010, available at <http://www.nytimes.com/2010/05/19/education/19dna.html> (last accessed Sep. 25, 2017); J. Ferris, “Exposing the Student Body: Stanford Joins U.C. Berkeley in Controversial Genetic Testing of Students,” July 6, 2010, available at <https://www.scientificamerican.com/article/exposing-the-student-body/> (last accessed Sep. 25, 2017); S. L. Callier, “Swabbing Students: Should Universities be Allowed to Facilitate Educational DNA Testing?” The American Journal of Bioethics 12, no. 4 (2012): 32-40, at 32.Google Scholar
Dick, D. M. et al., “Spit for Science: Launching a Longitudinal Study of Genetic and Environmental Influences on Substance Use and Emotional Health at a Large US University,” Frontiers in Genetics 5, Article 47 (2014): 112.CrossRefGoogle Scholar
Dick, D. M. and Hancock, L. C., “Integrating Basic Research with Prevention/Intervention to Reduce Risky Substance Use among College Students,” Frontiers in Psychology 6, Article 544 (2015): 16, at 4-5.Google Scholar
Snyder, T. D. and Dillow, S. A., Digest of Education Statistics 2012 (National Center for Education Statistics, Institute of Education Sciences, US Department of Education; Washington DC, 2013), available at <http://nces.ed.gov/pubs2014/2014015.pdf> (last accessed Sep. 25, 2017), at 198.Google Scholar
Wagner, M. M., “Outcomes for Youths with Serious Emotional Disturbance in Secondary School and Early Adulthood,” Critical Issues in Children & Youth 5, no. 2 (1995): 90112, at 100.Google Scholar
Burrell, S. and Warboys, L., “Special Education and the Juvenile Justice System,” Juvenile Justice Bulletin, July 2000, at 1, available at <http://youthjusticenc.org/download/juvenile-justice/juvenile-and-criminal-representation/Special%20Education%20and%20the%20Juvenile%20Justice%20System.pdf> (last accessed February 28, 2018).Google Scholar
See Dunn et al., supra note 7; Ptak and Petronis, supra note 28.Google Scholar
Grigorenko, supra note 1, at 22, 23; Plomin, R., Kovas, Y., and Haworth, C. M. A., “Generalist Genes: Genetic Links between Brain, Mind, and Education,” Mind Brain and Education 1, no. 1 (2007): 1119, at 17; C. M. A. Haworth and R. Plomin, “Genetics and Education: Toward a Genetically Sensitive Classroom,” in K. R. Harris et al., eds., APA Educational Psychology Handbook (Washington, D.C.: The American Psychological Association, 2012), 529-559 at 551-552; R. Plomin and S. O. Walker, “Genetics and Educational Psychology,” British Journal of Educational Psychology 73(Pt 1) (2003): 3-14, at 9-10.CrossRefGoogle Scholar
Grigorenko, supra note 1, at 23; Rothstein, M., “Legal Conceptions of Equality in the Genomic Age,” Law and Inequality 25, no. 2 (2007): 429471, at 459-460.Google Scholar
Lewis, G. J., Asbury, K., and Plomin, R., “Externalizing Problems in Childhood and Adolescence Predict Subsequent Educational Achievement but for Different Genetic and Environmental Reasons,” Journal of Child Psychology and Psychiatry 58, no. 3 (2017): 292304; M. R. Rueda et al., “Training, Maturation, and Genetic Influences on the Development of Executive Attention,” Proceedings of the National Academy of Sciences of the United States of America 102, no. 41 (2005): 14931-14936; R. M. Hodapp, and D. J. Fidler, “Special Education and Genetics: Connections for the 21st Century,” The Journal of Specical Educcation 33, no. 3 (1999): 130-137, at 134-135.CrossRefGoogle Scholar
Reilly, C., “Behavioural Phenotypes and Special Educational Needs: Is Aetiology Important in the Classroom?” Journal of Intellectual Disability Research 56, no. 10 (2012): 929946, at 934.CrossRefGoogle Scholar
Petrill, S. A. and Justice, L. M., “Bridging the Gap Between Genomics and Education,” Mind Brain and Education 1, no. 4 (2007): 153161, at 157.Google Scholar
Lawrence and Appelbaum, supra note 22, 323-324; Erickson et al., supra note 22, at 572.Google Scholar
Walker, S. O. and Plomin, R., “The Nature – Nurture Question: Teachers' Perceptions of How Genes and the Environment Influence Educationally Relevant Behavior,” Educational Psychology 25 (2005): 509516, at 512-513.CrossRefGoogle Scholar
Wilde, A. et al., “Community Attitudes to Genetic Susceptibility-Based Mental Health Interventions for Healthy People in a Large National Sample,” Journal of Affective Disorders 134, no. 1-3 (2011):280287, at 283; M. E. May, R. C. Brandt, and J. K. Bohannan, “Moderating Effects of Autism on Parent Views of Genetic Screening for Aggression,” Intellectual and Developmental Disabilities 50, no. 5 (2012): 415-425, at 420.CrossRefGoogle Scholar
Gason, A. A. et al., “Genetic Susceptibility Screening in Schools: Attitudes of the School Community towards Hereditary Haemochromatosis,” Clinical Genetics 67, no. 2 (2005): 166174, at 169, 170; Delatycki et al., supra note 35, at 244.Google Scholar
Walker and Plomin, supra note 53, at 512-13.Google Scholar
Gason et al., supra note 55, at 169.Google Scholar
Athanasiadis, G. et al., “Spitting for Science: Danish High School Students Commit to a Large-Scale Self-Reported Genetic Study,” PLoS One 11, no. 8 (2016): e0161822, at 2, 7.CrossRefGoogle Scholar
Grigorenko, supra note 1, at 21.Google Scholar
Haworth and Plomin, supra note 47, at 551-552.Google Scholar
Individuals with Disability Education Act (IDEA), 20 U.S.C. §§ 1414(a)(1), (b)(2)–(3); Timothy v. PASO Robles Unified School District, No. 14-55800, D.C. No. 2:12-cv-06385-JGB-JEM (U.S. Court of Appeals, Ninth Circuit; 2016), at 15-16, 27-32.Google Scholar
Chabris, C. F. et al., “Why It Is Hard to Find Genes Associated with Social Science Traits: Theoretical and Empirical Considerations,” American Journal of Public Health 103, Suppl 1 (2013): S152166, at S153.Google Scholar
Sullivan, P. F., Daly, M. J., and O'Donovan, M., “Genetic Architectures of Psychiatric Disorders: The Emerging Picture and Its Implications,” Nature Reviews Genetics 13, no. 8 (2012): 537551; P. F. Sullivan et al., “Psychiatric Genomics: An Update and an Agenda,” BioRxiv 2017, at 2-3, available at <https://www.biorxiv.org/content/early/2017/03/10/115600> (last accessed Sep. 25, 2017).CrossRefGoogle Scholar
Hart, S. J. et al., “Communication of Psychiatric Risk in 22q11.2 Deletion Syndrome: A Pilot Project,” Journal of Genetic Counseling 25, no. 1 (2016): 617, at 6.CrossRefGoogle Scholar
Young, A. S. et al., “Discordance in Diagnoses and Treatment of Psychiatric Disorders in Children and Adolescents with 22q11.2 Deletion Syndrome,” Asian Journal of Psychiatry 4, no. 2 (2011): 119124, at 119, 121CrossRefGoogle Scholar
See, e.g., Nestler, E. J. et al., “Epigenetic Basis of Mental Illness,” Neuroscientist 22, no. 5 (2016): 447463; R. Uher, “Gene-Environment Interactions in Severe Mental Illness,” Frontiers in Psychiatry 5, Article 48 (2014): 1-9.CrossRefGoogle Scholar
Turkheimer, E., “Mobiles: A Gloomy View of Research into Complex Human Traits,” in Parens, E., Chapman, A. R., Press, N., eds., Wrestling with Behavioral Genetics (Baltimore: John Hopkins University Press, 2006): 100108, at 103-104.Google Scholar
Id., at 105.Google Scholar
Appelbaum, P.S., “Who's Afraid of Psychiatric Genomics?,” The American Journal of Bioethics 17, no. 4 (2017): 1517, at 16.CrossRefGoogle Scholar
Sullivan, Daly, and O'Donovan, supra note 63, at 547-548.Google Scholar
Ripke, S. et al., on behalf of the Schizophrenia Working Group of the Psychiatric Genomics Consortium, “Biological Insights from 108 Schizophrenia-Associated Genetic Loci,” Nature 511, no. 7510 (2014): 421427.Google Scholar
Sullivan et al., “Psychiatric Genomics,” supra note 63, at 8.Google Scholar
Reilly, supra note 50, at 930.Google Scholar
The Family Educational Rights and Privacy Act (FERPA), 20 U.S.C. § 1232g; 34 CFR Part 99.Google Scholar
Chadam v. Palo Alto Unified School District, WL 325323 (N.D. Cal. 2014).Google Scholar
McGinty, E. E. et al., “Using Research Evidence to Reframe the Policy Debate around Mental Illness and Guns: Process and Recommendations,” American Journal of Public Health 104, no. 11 (2014): e2226, at e22.Google Scholar
Caspi, A. et al., “Role of Genotype in the Cycle of Violence in Maltreated Children,” Science 297, no. 5582 (2002): 851854 at 853.CrossRefGoogle Scholar
Caspi, A. et al., “Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene,” Science 301, no. 5631 (2003): 386389 at 388-389; M. Aguilera et al., “Early Adversity and 5-HTT/BDNF Genes: New Evidence of Gene-Environment Interactions on Depressive Symptoms in a General Population,” Psycholological Medicine 39, no. 9 (2009): 1425-1432, at 1429.CrossRefGoogle Scholar
Bakermans-Kranenburg, M. J. and van Ijzendoorn, M. H., “Gene-environment Interaction of the Dopamine D4 Receptor (DRD4) and Observed Maternal Insensitivity Predicting Externalizing Behavior in Preschoolers,” Developmental Psychobiology 48, no. 5 (2006): 406409, at 407-408; B. E. Sheese et al., “Parenting Quality Interacts with Genetic Variation in Dopamine Receptor D4 to Influence Temperament in Early Childhood,” Developement and Psychopathology 19, no. 4 (2007): 1039-1046, at 1042-1045; M. J. Bakermans-Kranenburg et al., “Experimental Evidence for Differential Susceptibility: Dopamine D4 Receptor Polymorphism (DRD4 VNTR) Moderates Intervention Effects on Toddlers' Externalizing Behavior in a Randomized Controlled Trial,” Developmental Psychology 44, no. 1 (2008): 293-300, at 296-298; A. Knafo, S. Israel, and R. P. Ebstein, “Heritability of Children's Prosocial Behavior and Differential Susceptibility to Parenting by Variation in the Dopamine Receptor D4 Gene,” Development and Psychopathology 23, no. 1 (2011): 53-67, at 63-64; E. Nederhof et al., “Effects of Divorce on Dutch Boys' and Girls' Externalizing Behavior in Gene x Environment Perspective: Diathesis Stress or Differential Susceptibility in the Dutch Tracking Adolescents' Individual Lives Survey Study?” Development and Psychopathology 24, no. 3 (2012): 929-939, at 935-937.Google Scholar
Liu, H., Li, Y., and Guo, G., “Gene by Social-Environment Interaction for Youth Delinquency and Violence: Thirty-Nine Aggression-related Genes,” Socical Forces 93, no. 3 (2015): 881903, at 896-897; K. M. Beaver et al., “The Interplay between Neighborhood and Individual Factors in the Explanation of Delinquency, Victimization, and Related Outcomes,” Youth Violence and Juvenile Justice 10, no. 1 (2012): 25-40, at 36.CrossRefGoogle Scholar
Belsky, L. et al., “Vulnerability Genes or Plasticity Genes?” Molecular Psychiatry 14, no. 8 (2009): 746754, at 751-752; J. Belsky, M. J. Bakermans-Kranenburg, and M. H. van IJzendoorn, “For Better and For Worse: Differential Susceptibility to Environmental Inluences,” Current Directions in Psychological Science 16, no. 6 (2007): 300-304, at 301-302.CrossRefGoogle Scholar
Prichard, Z. et al., “No Evidence for Interaction between MAOA and Childhood Adversity for Antisocial Behavior,” American Journal of Medical Genetics B: Neuropsychiatric Genetics 147b, no. 2 (2008): 228232, at 231; B. C. Haber-stick et al., “MAOA Genotype, Childhood Maltreatment, and Their Interaction in the Etiology of Adult Antisocial Behaviors,” Biological Psychiatry 75, no. 1 (2014): 25-30, at 29; E. Vassos, D. A. Collier, and S. Fazel, “Systematic Meta-Analyses and Field Synopsis of Genetic Association Studies of Violence and Aggression,” Molecular Psychiatry 19, no. 4 (2014): 471-477, at 472.CrossRefGoogle Scholar
Haworth and Plomin, “Genetics and Education,” supra note 47, at 551.Google Scholar
Korbin, J. E., “Child Maltreatment in Cross-cultural Perspective: Vulnerable Children and Circumstances,” in Gelles, R. J., Lancester, J. B., eds., Child Abuse and Neglect: Biosocial Dimensions (New York: Aldin De Gruyter, 1987): 3155, at 34.Google Scholar
Ferrari, A. M., “The Impact of Culture upon Child Rearing Practices and Definitions of Maltreatment,” Child Abuse and Neglect 26, no. 8 (2002): 793813, at 809-810.CrossRefGoogle Scholar
Hosp, J. L. and Reschly, D. J., “Referral Rates for Intervention or Assessment: A Meta-Analysis of Racial Differences,” Journal of Special Education 37, no. 2 (2003): 6780, at 68.Google Scholar
Aud, S., Fox, M. A., and Kew, A. Ramani, I, “Status and Trends in the Education of Racial and Ethnic Groups,” 2010, available at <https://nces.ed.gov/pubs2010/2010015.pdf> (last accessed February 28, 2018): at 23.Google Scholar
Rothstein, L.F., “Genetic Information in Schools,” in Rothstein, M., ed., Genetic Secrets: Protecting Privacy and Confidentiality in the Genetic Era (New Haven & London: Yale University Press, 1997): 317331, at 323; D. Wasserman, “Is There Value in Identifying Individual Genetic Predispositions to Violence?” Journal of Law, Medicine & Ethics 32, no. 1 (2004): 24-33, at 28.Google Scholar
Bayer, R. and Galea, S., “Public Health in the Precision-Medicine Era,” New England Journal of Medicine 373, no. 6 (2015): 499501, at 500.Google Scholar
Chaudry, A. and Wimer, C., “Poverty is Not Just an Indicator: The Relationship Between Income, Poverty, and Child Well-Being,” Academic Pediatrics 16, Suppl 3 (2016): S2329, at S26-7.CrossRefGoogle Scholar
John, P., “When Neurogenetics Hurts: Examining the Use of Neuroscience and Genetic Evidence in Sentencing Decisions Through Implicit Bias,” California Law Review 103, no. 4 (2015): 10191045, at 1027-1029.Google Scholar
Rothstein, M. A., “Currents in Contemporary Ethics: GINA, the ADA, and Genetic Discrimination in Employment,” Journal of Law, Medicine & Ethics 36, no. 4 (2008): 837840, at 838.Google Scholar
Id.; Commission USEEO, “What You Should Know about EEOC Regulations, Subregulatory Guidance and other Resource Documents,” available at <https://www1.eeoc.gov//eeoc/newsroom/wysk/regulations_guidance_resources.cfm?renderforprint=1> (last accessed Sep. 26, 2017).+(last+accessed+Sep.+26,+2017).>Google Scholar
Rothstein, supra note 48, at 459, 462.Google Scholar
Rothstein, supra note 88, at 323.Google Scholar
Caspi et al., supra note 78 at 388-389.Google Scholar
Dunn et al., supra note 7, at 11-14.Google Scholar
Beaver et al., supra note 80, at 28-29; Wasserman, supra note 88, at 28.Google Scholar
Boersma, G. J. et al., “Long-Term Impact of Early Life Events on Physiology and Behaviour,” Journal of Neuroendocrinology 26, no. 9 (2014): 587602; M.E. Bowers and R. Yehuda, “Intergenerational Transmission of Stress in Humans,” Neuropsychopharmacology 41, no. 1 (2016): 232-244, at 233-235.Google Scholar
Nelkin, D. and Tancredi, L., “Classify and Control: Genetic Information in the Schools,” American Journal of Law & Medicine 17, no. 1&2 (1991): 5173, at 70; D. Wasserman, “Ethical and Policy Issues in Genetic Prediction of Violence: Implications for Clinicians,” Current Genetic Medicine Reports 2, no. 4 (2014): 216-222, at 218-219.Google Scholar
Rothstein, supra note 88, at 323-324.Google Scholar
See, e.g., Phelan, J. C., Yang, L. H., Cruz-Rojas, R., “Effects of Attributing Serious Mental Illnesses to Genetic Causes on Orientations to Treatment,” Psychiatric Services 57, no. 3 (2006): 382387; B. A. Pescosolido et al., “‘A Disease Like Any Other?’ A Decade of Change in Public Reactions to Schizophrenia, Depression, and Alcohol Dependence,” American Journal of Psychiatry 167, no. 11 (2010): 1321-1330; A. M. Parcesepe and L. J. Cabassa, “Public Stigma of Mental Illness in the United States: A Systematic Literature Review,” Administration and Policy in Mental Health 40, no. 5 (2013): 384-399; J. Read et al., “Prejudice and Schizophrenia: A Review of the ‘Mental Illness Is an Illness Like Any Other’ Approach,” Acta Psychiatrica Scandinavica 114, no. 5 (2006): 303-318.CrossRefGoogle Scholar
Nelkin and Tancredi, supra note 100, at 66.Google Scholar
Walker and Plomin, supra note 53, at 515.Google Scholar
Id., at 512; Grigorenko, supra note 1, at 24.Google Scholar
Reilly, Senior, and Murtagh, supra note 1, 1099.Google Scholar
Dougherty, M. J., “Closing the Gap: Inverting the Genetics Curriculum to Ensure an Informed Public,” American Journal of Human Genetics 85, no. 1 (2009): 612, at 7; M. J. Dougherty et al., “A Comprehensive Analysis of High School Genetics Standards: Are States Keeping Pace with Modern Genetics?” CBE Life Sciences Education 10, no. 3 (2011): 318-327, at 324-326.CrossRefGoogle Scholar
Scurich, N. and Appelbaum, P. S., “The Blunt-Edged Sword: Genetic Explanations of Misbehavior Neither Mitigate Nor Aggravate Punishment,” Journal of Law and the Biosciences 3, no. 1 (2015): 140157, at 155.CrossRefGoogle Scholar
Walker and Plomin, supra note 53, at 512.Google Scholar
Rothstein, supra note 88, at 322; Nelkin and Tancredi, supra note 100, at 69-70.Google Scholar
Hoge, M. R. et al., “Examining Placement Considerations for Students with Emotional Disturbance Across Three Alternative Schools,” Journal of Disability Policy Studies 24, no. 4 (2014): 218226, at 223.Google Scholar
Power, T. J. et al., “Managing Attention-Deficit/Hyperactivity Disorder in Primary Care: A Systematic Analysis of Roles and Challenges,” Pediatrics 121, no. 1 (2008): e6572, at e66; K. A. Shaw, “Attitudes and Practices of General Practitioners in the Diagnosis and Management of Attention-Deficit/Hyperactivity Disorder,” Journal of Paediatrics and Child Health 38, no. 5 (2002): 481-486.Google Scholar
Finn, C. T. et al., “Psychiatric Genetics: A Survey of Psychiatrists' Knowledge, Opinions, and Practice Patterns,” Journal of Clinical Psychiatry 66, no. 7 (2005): 821830, at 824-825; N. A. Mikat-Stevens, I. A. Larson, and B. A. Tarini, “Primary-Care Providers' Perceived Barriers to Integration of Genetics Services: A Systematic Review of the Literature,” Genetics in Medicine 17, no. 3 (2015): 169-176, at 171-172; M. J. Baars, L. Henneman, and L. P. Ten Kate, “Deficiency of Knowledge of Genetics and Genetic Tests among General Practitioners, Gynecologists, and Pediatricians: A Global Problem,” Genetics in Medicine 7, no. 9 (2005): 605-610, at 608-609.Google Scholar
Lebowitz, M. S. and Ahn, W. K., “Effects of Biological Explanations for Mental Disorders on Clinicians' Epathy,” Proceedings of the National Academy of Sciences of the United States of America 111, no. 50 (2014): 1778617790, at 17788.CrossRefGoogle Scholar