Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-09T15:41:33.866Z Has data issue: false hasContentIssue false
  • English
  • Français

Xylometazoline hydrochloride 0.1 per cent versus physiological saline in nasal surgical aftercare: a randomised, single-blinded, comparative clinical trial

Published online by Cambridge University Press:  11 April 2008

M R Humphreys ,
D Grant ,
S A McKean ,
C Y Eng ,
J Townend  and
A S Evans
M R Humphreys*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Aberdeen Royal Infirmary, Scotland, UK
D Grant
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Aberdeen Royal Infirmary, Scotland, UK
S A McKean
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Aberdeen Royal Infirmary, Scotland, UK
C Y Eng
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Aberdeen Royal Infirmary, Scotland, UK
J Townend
Affiliation:
Department of Public Health, University of Aberdeen, Scotland, UK
A S Evans
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Aberdeen Royal Infirmary, Scotland, UK
*
Address for correspondence: Mr Mark R Humphreys, Flat 2A, 8 Shepherds Loan, Dundee DD2 1AX, Scotland, UK. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objectives:

A variety of topical preparations are used for symptomatic relief following nasal surgery. The aim of this study was to compare the effect of two commonly used products on patient symptom scores following nasal surgery.

Design:

Randomised, single-blinded, comparative clinical trial.

Setting:

A single, secondary otorhinolaryngology centre.

Participants:

One hundred and twenty patients undergoing septoplasty or functional endoscopic sinus surgery as an isolated procedure between November 2003 and January 2006. Patients undergoing additional nasal procedures were excluded, as were those requiring additional post-operative medications other than standardised analgesia.

Methods:

Following nasal surgery, patients were randomised to receive either xylometazoline hydrochloride 0.1 per cent nasal spray or a sterile physiological saline aerosol.

Main outcome measures:

Visual analogue scale symptom scores for nasal obstruction, rhinorrhoea, pain, loss of sense of smell and bleeding were assessed at day 10 post-operatively.

Results:

Post-operative symptom scores were compared between treatment groups. Overall, median pain scores were significantly higher in the xylometazoline group (p = 0.03, chi-square test). When analysed by procedure, median pain scores were significantly higher in septoplasty patients using xylometazoline (p = 0.019, chi-square test).

Conclusion:

There is no evidence to support the use of xylometazoline hydrochloride 0.1 per cent nasal spray over aerosolised physiological saline alone, following nasal surgery. Furthermore, there may be more pain associated with the post-operative use of xylometazoline.

Keywords

Paranasal SinusesOtorhinolaryngologic Surgical ProceduresPostoperative CareXylometazolineSaline
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 1 , January 2009 , pp. 85 - 90
Copyright
Copyright © JLO (1984) Limited 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Spraggs, PD, Macnamara, M, Joseph, T. A prospective randomized study to assess the efficacy of post-operative nasal medication after endonasal surgery J Laryngol Otol 1995;109:618–21CrossRefGoogle ScholarPubMed
2 Pigret, D, Jankowski, R. Management of post-ethmoidectomy crust formation: randomized single-blind clinical trial comparing pressurized seawater versus antiseptic/mucolytic saline Rhinology 1996;34:38–40Google ScholarPubMed
3 Jorissen, M. Postoperative care following endoscopic sinus surgery Rhinology 2004;42:114–20Google ScholarPubMed
4 Pinto, JM, Elwany, S, Baroody, FM, Naclerio, RM. Effects of saline sprays on symptoms after endoscopic sinus surgery. Am J Rhinol 2006;20:191–6CrossRefGoogle ScholarPubMed
5 Talbot, AR, Herr, TM, Parsons, DS. Mucociliary clearance and buffered hypertonic saline solution. Laryngoscope 1997;107:500–3CrossRefGoogle ScholarPubMed
6 Keojampa, BK, Nguyen, MH, Ryan, MW. Effects of buffered saline solution on nasal mucociliary clearance and nasal airway patency Otolaryngol Head Neck Surg 2004;131:679–82CrossRefGoogle ScholarPubMed
7 Homer, JJ, Dowley, AC, Condon, L, El-Jassar, P, Sood, S. The effect of hypertonicity on nasal mucociliary clearance. Clin Otolaryngol Allied Sci 2000;25:558–60CrossRefGoogle ScholarPubMed
8 Wabnitz, DA, Wormald, PJ. A blinded, randomized, controlled study on the effect of buffered 0.9% and 3% sodium chloride intranasal sprays on ciliary beat frequency. Laryngoscope 2005;115:803–5CrossRefGoogle Scholar
9 Min, YG, Lee, KS, Yun, JB, Rhee, CS, Rhyoo, C, Koh, YY et al. Hypertonic saline decreases ciliary movement in human nasal epithelium in vitro. Otolaryngol Head Neck Surg 2001;124:313–16CrossRefGoogle ScholarPubMed
10 Kemppainen, TP, Henri, T, Hannu, K, Juha, S, Juhani, N. Pain treatment and recovery after endoscopic sinus surgery. Laryngoscope 2007;117:1434–8CrossRefGoogle ScholarPubMed
11 Kemppainen, T, Kokki, H, Tuomilehto, H, Seppä, J, Nuutinen, J. Acetaminophen is highly effective in pain treatment after endoscopic sinus surgery. Laryngoscope 2006;116:2125–8CrossRefGoogle ScholarPubMed
12 Church, CA, Stewart, C, O-Lee, TJ, Wallace, D. Rofecoxib versus hydrocodone/acetaminophen for postoperative analgesia in functional endoscopic sinus surgery. Laryngoscope 2006;116:602–6CrossRefGoogle ScholarPubMed