Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-26T13:49:41.775Z Has data issue: false hasContentIssue false
  • English
  • Français

Well-differentiated liposarcoma arising in the parapharyngeal space: a case report and review of the literature

Published online by Cambridge University Press:  23 February 2015

N Kikuchi ,
T Nakashima ,
J Fukushima ,
K Nariyama  and
S Komune
N Kikuchi*
Affiliation:
Department of Otorhinolaryngology, Yamaguchi Red Cross Hospital, Yamaguchi, Japan
T Nakashima
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Fukushima
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Plastic and Reconstructive Surgery, Fukuoka Red Cross Hospital, Fukuoka, Japan
K Nariyama
Affiliation:
Department of Otorhinolaryngology, Ekisaikai Moji Hospital, Fukuoka, Japan
S Komune
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
*
Address for correspondence: N Kikuchi, Department of Otorhinolaryngology, Yamaguchi Red Cross Hospital, Yahatababa 53–1, Yamaguchi-City, Yamaguchi 753–0092, Japan Fax:+81 83 925 1474 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Liposarcomas rarely occur in the parapharyngeal space and only a few case reports exist. For curative therapy of liposarcoma, surgical excision remains the dominant modality. Although a wide surgical margin is important to prevent local recurrence, wide excision is often difficult in the head and neck region.

Case report:

We report a case of a 19-year-old female with a well-differentiated liposarcoma arising in the parapharyngeal space. We removed the tumour surgically utilising a cervical–parotid approach. The histological diagnosis was well-differentiated sclerosing liposarcoma. There is no recurrence after five years and nine months of follow up.

Conclusion:

The patient's age and the tumour site made it difficult for us to make a quantitative diagnosis before the operation. Well-differentiated liposarcoma rarely develop distant metastasis, but often recur locally. The benefit of adjuvant radiotherapy for well-differentiated liposarcoma is still not clear and careful and long-term follow up is necessary.

Keywords

LiposarcomaPharyngeal diseasePathological classificationSurgical approach
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue S2 , March 2015 , pp. S86 - S90
Copyright
Copyright © JLO (1984) Limited 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Toro, JR, Travis, LB, Wu, HJ, Zhu, K, Fletcher, CD, Devesa, SS. Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results program, 1978–2001: an analysis of 26 758 cases. Int J Cancer 2006;119:2922–30CrossRefGoogle Scholar
2Engström, K, Bergh, P, Gustafson, P, Hultborn, R, Johansson, H, Löfvenberg, R et al. Liposarcoma: outcome based on the Scandinavian Sarcoma Group register. Cancer 2008;113:1649–56CrossRefGoogle ScholarPubMed
3van Vliet, M, Kliffen, M, Krestin, GP, van Dijke, CF. Soft tissue sarcomas at a glance: clinical, histological, and MR imaging features of malignant extremity soft tissue tumors. Eur Radiol 2009;19:1499–511CrossRefGoogle Scholar
4Fletcher, CDM, Unni, KK, Mertens, F. Pathology and Genetics of Tumours of Soft Tissue and Bone. WHO Classification of Tumours, Lyon, France: IARC Press, 2002Google Scholar
5Kooby, DA, Antonescu, CR, Brennan, MF, Singer, S. Atypical lipomatous tumor/well-differentiated liposarcoma of the extremity and trunk wall: importance of histological subtype with treatment recommendations. Ann Surg Oncol 2004;11:78–84Google Scholar
6Singer, S, Antonescu, CR, Riedel, E, Brennan, MF. Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg 2003;238:358–70CrossRefGoogle ScholarPubMed
7Chang, HR, Hajdu, SI, Collin, C, Brennan, MF. The prognostic value of histologic subtypes in primary extremity liposarcoma. Cancer 1989;64:1514–203.0.CO;2-2>CrossRefGoogle ScholarPubMed
8Antonescu, CR, Tschernyavsky, SJ, Decuseara, R. Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases. Clin Cancer Res 2001;7:3977–87Google ScholarPubMed
9Weiss, SW, Rao, VK. Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellaneous sites. A follow-up study of 92 cases with analysis of the incidence of “dedifferentiation”. Am J Surg Pathol 1992;16:1051–8CrossRefGoogle Scholar
10Lucas, DR, Nascimento, AG, Sanjay, BK, Rock, MG. Well-differentiated liposarcoma. The Mayo Clinic experience with 58 cases. Am J Clin Pathol 1994;102:677–83CrossRefGoogle Scholar
11Dalal, KM, Kattan, MW, Antonescu, CR, Brennan, MF, Singer, S. Subtype specific prognostic nomogram for patients with primary liposarcoma of the retroperitoneum, extremity, or trunk. Ann Surg 2006;244:381–91Google Scholar
12Golledge, J, Fisher, C, Rhys-Evans, PH. Head and neck liposarcoma. Cancer 1995;76:1051–83.0.CO;2-4>CrossRefGoogle ScholarPubMed
13de Vreeze, RS, de Jong, D, Haas, RL, Stewart, F, van Coevorden, F. Effectiveness of radiotherapy in myxoid sarcomas is associated with a dense vascular pattern. Int J Radiat Oncol Biol Phys 2008;72:1480–7CrossRefGoogle ScholarPubMed