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Wegener's granulomatosis, subglottic stenosis and antineutrophil cytoplasm antibodies.

Published online by Cambridge University Press:  29 June 2007

T. J. Hoare ,
D. Jayne ,
P. Rhys Evans ,
C. B. Croft  and
D. J. Howard
T. J. Hoare*
Affiliation:
Royal National Throat Nose and Ear Hospital, Grays Inn Road, London WC1X8DA
D. Jayne
Affiliation:
University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ
P. Rhys Evans
Affiliation:
Royal Marsden Hospital, Fulham Road, London SW3
C. B. Croft
Affiliation:
Royal National Throat Nose and Ear Hospital, Grays Inn Road, London WC1X8DA
D. J. Howard
Affiliation:
Royal National Throat Nose and Ear Hospital, Grays Inn Road, London WC1X8DA
*
Mr. T. J. Hoare, FRCS, ENT Registrar, Dudley Road Hospital, Dudley Road, Birmingham
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Abstract

Wegener's granulomatosis is difficult to diagnose, especially when the presentation is unusual, restricted to an isolated region. We report four cases of recurrent subglottic stenosis posing difficulty in diagnosis. In each case the finding of anti-neutrophil cytoplasm antibodies (ANCA) strongly suggested an underlying vasculitic pathology, Wegener's granulomatosis. We discuss reasons for the difficulty in diagnosis in the past, the possible role of the ANCA assay in such patients, and suggest it should be more widely used in the future.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 12 , December 1989 , pp. 1187 - 1191
Copyright
Copyright © JLO (1984) Limited 1989

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