Hostname: page-component-586b7cd67f-2brh9 Total loading time: 0 Render date: 2024-11-28T03:13:09.276Z Has data issue: false hasContentIssue false

Vestibular-evoked myogenic potentials and caloric stimulation in infants with congenital cytomegalovirus infection

Published online by Cambridge University Press:  21 September 2007

O Zagólski*
Affiliation:
Department of Otorhinolaryngology, ‘Medicina’ Diagnostic and Therapeutic Medical Centre, Kraków, Poland
*
Address for correspondence: Dr Olaf Zagólski, ul Dunin-Wąsowicza 20/II/9, 30-112 Kraków, Poland. E-mail: [email protected]

Abstract

Background:

The influence of congenital cytomegalovirus infection on cochlear function has been well recognised; however, its impact on the vestibular system in infants has not been examined. The purpose of the present study was to evaluate vestibular function in a group of infants, using caloric stimulation tests and vestibular-evoked myogenic potential measurements.

Materials and methods:

Vestibular-evoked myogenic potentials and auditory brainstem responses were recorded and caloric stimulation was performed in 66 infants aged three months, comprising 40 healthy controls and 26 infants with congenital cytomegalovirus infection.

Results:

No reaction to caloric stimulation was elicited from 16 examined ears, no vestibular-evoked myogenic potentials were recorded from 12 ears, and profound sensorineural hearing loss was diagnosed in eight ears. Pathological results were observed predominantly in infants with symptoms of intrauterine congenital cytomegalovirus infection present at birth.

Conclusions:

In infants with clinical symptoms of congenital CMV infection present at birth, abnormal vestibular test results occurred more frequently than abnormal auditory brainstem response results. Vestibular organs should be routinely examined in individuals with congenital cytomegalovirus infection.

Type
Main Article
Copyright
Copyright © JLO (1984) Limited 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Lagasse, N, Dhooge, I, Govaert, P. Congenital CMV infection and hearing loss. Acta Otorhinolaryngol Belg 2000;54:431–6Google ScholarPubMed
2 Ratyńska, J, Grzanka, A, Mueller-Malesińska, M, Skar΀yński, H, Hatzopoulos, S. Correlations between risk factors for hearing impairment and TEOAE screening test outcome in neonates at risk for hearing loss. Scand Audiol Suppl 2001;52:1517CrossRefGoogle Scholar
3 Haginoya, K, Ohura, T, Kon, K, Yagi, T, Sawaishi, Y, Ishii, KK. Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: retrospective diagnosis by PCR using Guthrie cards. Brain Dev 2002;24:710–14CrossRefGoogle ScholarPubMed
4 Griffiths, PD. Strategies to prevent CMV infection in the neonate. Semin Neonatol 2002;7:293–9CrossRefGoogle ScholarPubMed
5 Rivera, LB, Boppana, SB, Fowler, KB, Britt, WJ, Stagno, S, Pass, RF. Predictors of hearing loss in children with symptomatic congenital cytomegalovirus infection. Pediatrics 2002;110:762–7CrossRefGoogle ScholarPubMed
6 Nance, WE, Lim, BG, Dodson, KM. Importance of congenital cytomegalovirus infections as a cause for pre-lingual hearing loss. J Clin Virol 2006;35:221–5CrossRefGoogle ScholarPubMed
7 Strauss, M. A clinical pathologic study of hearing loss in congenital cytomegalovirus infection. Laryngoscope 1985;95:951–62CrossRefGoogle ScholarPubMed
8 Brantberg, K, Fransson, PA. Symmetry measures of vestibular evoked myogenic potentials using objective detection criteria. Scand Audiol 2001;30:189–96CrossRefGoogle ScholarPubMed
9 Sasaki, O, Asawa, S, Katsuno, S, Usami, S, Taguchi, K. The effects of intense click sounds on velocity storage in optokinetic after-nystagmus. Eur Arch Otorhinolaryngol 2000;257:490–2CrossRefGoogle ScholarPubMed
10 Versino, M, Colnaghi, S, Callieco, R, Cosi, V. Vestibular evoked myogenic potentials: test-retest reliability. Funct Neurol 2001;16:299309Google ScholarPubMed
11 Wu, CH, Young, YH, Murofushi, T. Tone burst-evoked myogenic potentials in human neck flexor and extensor. Acta Otolaryngol 1999;119:741–4Google ScholarPubMed
12 Colebatch, JG, Halmagyi, GM. Vestibular evoked potentials in human neck muscles before and after unilateral vestibular deafferentation. Neurology 1992;42:1635–40CrossRefGoogle ScholarPubMed
13 Young, YH, Huang, TW, Cheng, PW. Vestibular evoked myogenic potentials in delayed endolymphatic hydrops. Laryngoscope 2002;112:1623–6CrossRefGoogle ScholarPubMed
14 Takegoshi, H, Murofushi, T. Effect of white noise on vestibular evoked myogenic potentials. Hear Res 2003;176:5964CrossRefGoogle ScholarPubMed
15 Zagólski, O et al. . Vestibular-evoked myogenic potentials – the literature review based on recordings in infants with impaired inner ear function. Case Rep Clin Pract Rev 2005;6:80–4Google Scholar
16 Sheykholesami, K, Kaga, K, Megerian, CA, Arnold, JE. Vestibular-evoked myogenic potentials in infancy and early childhood. Laryngoscope 2005;115:1440–4CrossRefGoogle Scholar
17 Ochi, K, Ohashi, T, Nishino, H. Variance of vestibular-evoked myogenic potentials. Laryngoscope 2001;111:522–7CrossRefGoogle ScholarPubMed
18 Akin, FW, Murnane, OD, Proffitt, TM. The effects of click and toneburst stimulus parameters on the vestibular evoked myogenic potential (VEMP). J Am Acad Audiol 2003;14:500–9Google ScholarPubMed
19 Cheng, PW, Huang, TW, Young, YH. The influence of clicks versus short tone bursts on the vestibular evoked myogenic potentials. Ear Hear 2003;24:195–7CrossRefGoogle ScholarPubMed
20 Eviatar, L, Eviatar, A. Aminoglycoside ototoxicity in the neonatal period: possible etiologic factor delayed postural control. Otolaryngol Head Neck Surg 1981;89:818–21CrossRefGoogle ScholarPubMed
21 Eviatar, L, Miranda, S, Eviatar, A, Freeman, K, Borkowski, M. Development of nystagmus in response to vestibular stimulation in infants. Ann Neurol 1979;5:508–14CrossRefGoogle ScholarPubMed
22 Angeli, S. Value of vestibular testing in young children with sensorineural hearing loss. Arch Otolaryngol Head Neck Surg 2003;129:478–82CrossRefGoogle ScholarPubMed
23 Fife, TD, Tusa, RJ, Furman, JM, Zee, DS, Frohman, E, Baloh, RW et al. Assessment: vestibular testing techniques in adults and children. Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2000;55:1431–41CrossRefGoogle ScholarPubMed
24 Ornitz, EM, Honrubia, V. Developmental modulation of vestibular-ocular function. Adv Otorhinolaryngol 1988;41:36–9Google ScholarPubMed
25 Lipitz, S, Achiron, R, Zalel, Y, Mendelson, E, Tepperberg, M, Gamzu, R. Outcome of pregnancies with vertical transmission of primary cytomegalovirus infection. Obstet Gynecol 2002;100:428–33Google ScholarPubMed
26 Yang, TL, Young, YH. Comparison of tone burst and tapping evocation of myogenic potentials in patients with chronic otitis media. Ear Hear 2003;24:191–4CrossRefGoogle ScholarPubMed
27 Cheng, PW, Murofushi, T. The effects of plateau time on vestibular-evoked myogenic potentials triggered by tone bursts. Acta Otolaryngol 2001;121:935–8CrossRefGoogle ScholarPubMed
28 Zagólski, O et al. . Functional evaluation of the vestibular organ in infants with risk factors for hearing loss occurring in the perinatal period. Med Sci Monit 2006;12:248–52Google ScholarPubMed
29 Vatovec, J, Velikovic, M, Smid, L, Brenk, K, Zargi, M. Impairments of vestibular system in infants at risk of early brain damage. Scand Audiol Suppl 2001;52:191–3CrossRefGoogle Scholar
30 Fowler, KB, Dahle, AJ, Boppana, SB, Pass, RF. Newborn hearing screening: will children with hearing loss caused by congenital cytomegalovirus infection be missed? J Pediatr 1999;135:60–4CrossRefGoogle ScholarPubMed