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Use of protein electrophoresis in the diagnosis of cerebrospinal fluid rhinorrhoea

Published online by Cambridge University Press:  29 June 2007

M. J. Porter ,
G. B. Brookes ,
A. Z. J. Zeman  and
G. Keir
M. J. Porter*
Affiliation:
Departments of Neuro-otology and Clinical Neurochemistry, The National Hospital for Neurology and Neurosurgery, Queen Square. London WCIN 3BG.
G. B. Brookes
Affiliation:
Departments of Neuro-otology and Clinical Neurochemistry, The National Hospital for Neurology and Neurosurgery, Queen Square. London WCIN 3BG.
A. Z. J. Zeman
Affiliation:
Departments of Neuro-otology and Clinical Neurochemistry, The National Hospital for Neurology and Neurosurgery, Queen Square. London WCIN 3BG.
G. Keir
Affiliation:
Departments of Neuro-otology and Clinical Neurochemistry, The National Hospital for Neurology and Neurosurgery, Queen Square. London WCIN 3BG.
*
Mr M. J. Porter, F.R.C.S., Royal National Throat Nose and Ear Hospital, Grays Inn Road, London WC1X8DA.
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Abstract

The diagnosis of CSF rhinorrhoea on clinical grounds alone can be difficult. We describe how the use of noninvasive electrophoretic analysis of nasal secretions for tau protein (asialotransferrin) helped in the management of cases where the existence of a CSF leak was in doubt. Patients were thus saved unnecessary invasive investigations or surgery. A modification of the method of analysis, which improves diagnostic accuracy, is described.

Keywords

Cerebrospinal fluidElectrophoresis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 6 , June 1992 , pp. 504 - 506
Copyright
Copyright © JLO (1984) Limited 1992

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