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Tubular e-PTFE implants in glottal and neoglottal insufficiency: tolerance and stability in an animal model

Published online by Cambridge University Press:  08 March 2006

Paolo Tamplenizza ,
Fabio Acocella ,
Flaminio Addis  and
Enrico Bolandrini
Paolo Tamplenizza
Affiliation:
Department of Otorhinolaryngology, Ospedale Maggiore Policlincio IRCCS, University of Milan, Italy.
Fabio Acocella
Affiliation:
Department of Otorhinolaryngology, Veterinary Surgical Clinic, University of Milan, Italy.
Flaminio Addis
Affiliation:
Department of Otorhinolaryngology, Veterinary Surgical Clinic, University of Milan, Italy.
Enrico Bolandrini
Affiliation:
Department of Otorhinolaryngology, Ospedale Maggiore Policlincio IRCCS, University of Milan, Italy.
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Abstract

The aim of our research is to develop a laryngeal tissue augmentation technique that will be useful in treating glottal and neoglottal insufficiency.

In a previous study the feasibility of insertion of tubular expanded polytetrafluoroethylene (e-PTFE) tissue implants into the larynx of a porcine model was demonstrated. In this paper we report the clinical, endoscopic, computed tomography (CT) and magnetic resonance image (MRI) and histopathological follow-up findings. These results demonstrate host tolerance of the implant over the period of study (six months) with little tissue reactivity to tubular e-PTFE implants in the porcine model. The tubular shape of the implant enhances stabilization by the rapid and complete host tissue penetration of the implant’s interstices, making tubular e-PTFE a potentially useful soft tissue augmentation material for larygneal incompetence.

Keywords

Surgical ProceduresOperativeLarynx
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 115 , Issue 2 , February 2001 , pp. 106 - 111
Copyright
© Royal Society of Medicine Press Limited 2001

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