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Trans-nasal injection of botulinum toxin

Published online by Cambridge University Press:  19 March 2009

A Hussain ,
G Thiel  and
M Shakeel
A Hussain*
Affiliation:
Department of Otolaryngology Head and Neck Surgery, University of Aberdeen, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, Scotland, UK
G Thiel
Affiliation:
Department of Otolaryngology Head and Neck Surgery, University of Aberdeen, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, Scotland, UK
M Shakeel
Affiliation:
Department of Otolaryngology Head and Neck Surgery, University of Aberdeen, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, Scotland, UK
*
Address for correspondence: Mr Akhtar Hussain, Consultant Otolaryngologist Head and Neck Surgeon, Department of Otolaryngology Head and Neck Surgery, Ward 45, Aberdeen Royal Infirmary, Foresterhill Road, Aberdeen AB25 2ZN, Scotland, UK. Fax: +44 1224554569 E-mail: [email protected]
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Abstract

Introduction:

Office-based laryngeal injection for the treatment of a variety of voice disorders is an established practice. Various methods of delivery to the vocal folds are in practice.

Aim:

We present a simple and repeatable method of injecting botulinum toxin into the larynx.

Method:

Botulinum toxin A (Botox®) was delivered into the larynx using a channelled fibre-optic laryngoscope under local anaesthetic, in an office setting.

Results:

Seven patients received regular botulinum toxin injections, via our preferred method. The treatment intervals and dosage regime varied depending on patient requirements. The procedure was carried out in an office setting, with minimal discomfort and inconvenience to the patient.

Conclusion:

We present a method of botulinum toxin delivery to the larynx which is simple, easily repeatable and simply learnt by the otolaryngologist familiar with fibre-optic laryngoscope usage. This method is also comfortable and convenient for the patient.

Keywords

Spasmodic DysphoniaAdductorBotoxBotulinum ToxinDrug Delivery Systems
Type
Short Communications
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 7 , July 2009 , pp. 783 - 785
Copyright
Copyright © JLO (1984) Limited 2009

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References

1 Bielamowicz, S, Ludlow, CL. Effects of botulinum toxin on pathophysiology in spasmodic dysphonia. Ann Otol Rhinol Laryngol 2000;109:194–203CrossRefGoogle ScholarPubMed
2 Rubin, AD, Wodchis, WP, Spak, C, Kileny, PR, Hogikyan, ND. Longitudinal effects of Botox injections on voice-related quality of life (V-RQOL) for patients with adductory spasmodic dysphonia: part II. Arch Otolaryngol Head Neck Surg 2004;130:415–20CrossRefGoogle ScholarPubMed
3 Adler, CH, Bansberg, SF, Hentz, JG, Ramig, LO, Buder, EH, Witt, K et al. Botulinum toxin type A for treating voice tremor. Arch Neurol 2004;61:1416–20CrossRefGoogle ScholarPubMed
4 Ford, CN, Roy, N, Sandage, M, Bless, DM. Rigid endoscopy for monitoring indirect vocal fold injection. Laryngoscope 1998;108:1584–6CrossRefGoogle ScholarPubMed
5 Kendall, KA, Leonard, RJ. Treatment of ventricular dysphonia with botulinum toxin. Laryngoscope 1997;107:948–53CrossRefGoogle ScholarPubMed
6 Miller, RH, Woodson, GE, Jankovic, J. Botulinum toxin injection of the vocal fold for spasmodic dysphonia. A preliminary report. Arch Otolaryngol Head Neck Surg 1987;113:603–5CrossRefGoogle ScholarPubMed
7 Ford, CN, Bless, DM, Lowery, JD. Indirect laryngoscopic approach for injection of botulinum toxin in spasmodic dysphonia. Otolaryngol Head Neck Surg 1990;103:752–8CrossRefGoogle ScholarPubMed
8 Rhew, K, Fiedler, DA, Ludlow, CL. Technique for injection of botulinum toxin through the flexible nasolaryngoscope. Otolaryngol Head Neck Surg 1994;111:787–94CrossRefGoogle ScholarPubMed
9 Truong, DD, Bhidayasiri, R. Botulinum toxin therapy of laryngeal muscle hyperactivity syndromes: comparing different botulinum toxin preparations. Eur J Neurol 2006;13 (suppl 1):36–41CrossRefGoogle ScholarPubMed
10 Boutsen, F, Cannito, MP, Taylor, M, Bender, B. Botox treatment in adductor spasmodic dysphonia: a meta-analysis. J Speech Lang Hear Res 2002;45:469–81CrossRefGoogle ScholarPubMed