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Tranexamic acid in sinus and nasal surgery: an up-to-date meta-analysis

Published online by Cambridge University Press:  27 October 2021

D Yap ,
A Shakir  and
A Hunt
D Yap*
Affiliation:
Department of Otorhinolaryngology, Milton Keynes University Hospital, Milton Keynes, UK
A Shakir
Affiliation:
Department of Otorhinolaryngology, Milton Keynes University Hospital, Milton Keynes, UK
A Hunt
Affiliation:
Department of Otorhinolaryngology, Milton Keynes University Hospital, Milton Keynes, UK
*
Author for correspondence: Dr D Yap, Department of Otorhinolaryngology, Milton Keynes University Hospital, Standing Way, Eaglestone, Milton Keynes MK6 5LD, UK E-mail: [email protected]
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Abstract

Objective

There are gaps within current meta-analyses looking at the effects of tranexamic acid on sino-nasal surgery. This study aimed to update and summarise all current available evidence on the use of tranexamic acid in sino-nasal surgery.

Method

A literature search was performed using four medical databases, Cochrane Library, Embase, Medline and PubMed. Data analysis was performed using dedicated meta-analysis software Review Manager (Revman).

Results

Thirteen studies were included in the meta-analysis. The amount of blood loss and duration of surgery in tranexamic acid groups was statistically lower than placebo for both sinus and nasal surgery. Tranexamic acid improves the surgical field quality in sinus surgery but worsens the field in nasal surgery. Topical or intravenous administration of tranexamic acid in sinus surgery reduces blood loss, duration of surgery and improves the quality of the surgical field.

Conclusion

This study suggests that the use of tranexamic acid in sinus surgery reduces blood loss, decreases surgical duration and improves surgical field quality.

Keywords

Tranexamic AcidTissue Plasminogen ActivatorNasal Surgical ProceduresBlood Loss, SurgicalRhinoplastyOtolaryngologyNose
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 8 , August 2022 , pp. 692 - 702
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr D Yap takes responsibility for the integrity of the content of the paper

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