Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-24T05:29:16.421Z Has data issue: false hasContentIssue false
  • English
  • Français

Superselective, intra-arterial, rapid infusion chemotherapy for external auditory canal carcinoma

Published online by Cambridge University Press:  22 May 2009

Y Ueda ,
T Kurita ,
Y Matsuda ,
S Ito  and
T Nakashima
Y Ueda*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
T Kurita
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
Y Matsuda
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
S Ito
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
T Nakashima
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
*
Address for correspondence: Dr Yoshihisa Ueda, Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan. Fax: +81 942 37 1200 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Previously, the treatment of carcinoma of the external auditory canal has mainly involved surgical resection. In order to enable organ preservation and to obtain cancer-free surgical margins, we introduced the use of superselective, intra-arterial, rapid infusion chemotherapy combined with radiotherapy to treat this condition.

We reviewed our patients' tumour stages, feeding arteries and clinical outcomes. Tumours were staged according to the Pittsburgh staging system. Chemotherapy was administered intra-arterially in the angiography suite via transfemoral catheterisation of the feeding arteries. Four patients underwent superselective, intra-arterial, rapid infusion chemo-radiotherapy. A complete response was obtained in all four patients. The overall toxic side effects were modest.

Superselective, intra-arterial, rapid infusion chemotherapy can be an effective, organ-preserving treatment for external auditory canal carcinoma, with a high cure rate.

Keywords

Superselective Intra-arterial Infusion ChemotherapySquamous Cell CarcinomaExternal Auditory CanalCurative Effect
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 123 , Supplement S31 , May 2009 , pp. 75 - 80
Copyright
Copyright © JLO (1984) Limited 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Arriaga, M, Curtin, H, Takahashi, H, Hirsch, BE, Kamerer, DB. Staging proposal for external auditory meatus carcinoma based on preoperative clinical examination and computed tomography findings. Ann Otol Rhinol Laryngol 1990;99:714–21Google Scholar
2Arena, S, Keen, M. Carcinoma of the middle ear and temporal bone. Am J Otolaryngol 1988;9:351–6Google ScholarPubMed
3Nakagawa, T, Kumamoto, Y, Natori, Y, Shiratsuchi, H, Toh, K, Kakazu, Y et al. Squamous cell carcinoma of the external auditory canal and middle ear: an operation combined with preoperative chemoradiotherapy and a free surgical margin. Otol Neurotol 2006;27:242–9CrossRefGoogle Scholar
4Ogawa, K, Nakamura, K, Hatano, K, Uno, T, Fuwa, N, Itami, J et al. Treatment and prognosis of squamous cell carcinoma of the external auditory canal and middle ear: a multi-institutional retrospective review of 87 patients. Int J Radiat Oncol Biol Phys 2007;68:1326–34CrossRefGoogle ScholarPubMed
5Pemberton, LS, Swindell, R, Sykes, AJ. Primary radical radiotherapy for squamous cell carcinoma of the middle ear and external auditory canal – a historical series. Clin Oncol 2006;18:390–4CrossRefGoogle ScholarPubMed
6Wang, CC. Radiation therapy in management of carcinoma of the external auditory canal, middle ear, or mastoid. Radiology 1975;116:713–15CrossRefGoogle ScholarPubMed
7Hashi, N, Shirato, H, Omatsu, T, Kagei, K, Nishioka, T, Hashimoto, S et al. The role of radiotherapy in treating squamous cell carcinoma of the external auditory canal, especially in early stages of disease. Radiother Oncol 2000;56:221–5CrossRefGoogle ScholarPubMed
8Austin, JR, Stewart, KL, Fawzi, N. Squamous cell carcinoma of the external auditory canal. Therapeutic prognosis based on a proposed staging system. Arch Otolaryngol Head Neck Surg 1994;120:1228–32Google Scholar
9Stell, PM, McCormick, MS. Carcinoma of the external auditory meatus and middle ear. Prognostic factors and a suggested staging system. J Laryngol Otol 1985;99:847–50Google Scholar
10Korzeniowski, S, Pszon, J. The results of radiotherapy of cancer of the middle ear. Int J Radiat Oncol Biol Phys 1990;18:631–63Google Scholar
11Yin, M, Ishikawa, K, Honda, K, Arakawa, T, Harabuchi, Y, Nagabashi, T et al. Analysis of 95 cases of squamous cell carcinoma of the external and middle ear. Auris Nasus Larynx 2006;33:251–7CrossRefGoogle ScholarPubMed
12Nyrop, M, Grontved, A. Cancer of the external auditory canal. Arch Otolaryngol Head Neck Surg 2002;128:834–7CrossRefGoogle ScholarPubMed
13Goodwin, WJ, Jesse, R. Malignant neoplasms of the EAC and temporal bone. Arch Otolaryngol Head Neck Surg 1980;106:675–9CrossRefGoogle Scholar
14Pignon, JP, Bourhis, J, Domenge, C, Designe, L. Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma: three meta analyses of updated individual data. MACH-NC Collaborative Group/ Meta-analysis of Chemotherapy on Head and Neck cancer. Lancet 2000;355:949–55CrossRefGoogle Scholar
15Al-Sarrf, M, Marts, K, Herskovic, A, Leichman, L, Brindle, JS, Vaitkevicius, VK et al. Progress report of combined chemoradiotherapy versus radiotherapy alone in patients with esophageal cancer: an intergroup study. J Clin Oncol 1997;15:277–84Google Scholar
16Robbins, KT, Staniolo, AM, Kerber, C, Seagren, S, Berson, A, Howell, SB. Rapid superselective high dose cisplatin infusion for advanced head and neck malignancies. Head Neck 1992;14:364–71Google Scholar
17Los, G, Blommaert, A, Barton, R, Heath, DD, den Engelse, L, Hanchett, C et al. Selective intra-arterial infusion of high dose cisplatin in patients with advanced head and neck cancer results in high tumor platinum concentrations and cisplatin-DNA adduct formation. Cancer Chemother Pharmacol 1995;37:150–4CrossRefGoogle ScholarPubMed
18Robbins, KT, Vicario, D, Seagren, S, Weisman, R, Pellitteri, P, Kerber, C et al. A targeted superdose cisplatin chemoradiation protocol for advanced head and neck cancer. Am J Surg 1994;168:419–21CrossRefGoogle Scholar
19Robbins, KT, Fontanesi, J, Wong, FS, Vicario, D, Seagren, S, Kumar, P et al. A novel organ preservation protocol for advanced carcinoma of the larynx and pharynx. Arch Otolaryngol Head Neck Surg 1996;122:853–7Google Scholar
20Robbins, KT, Kumar, P, Wong, FS, Hartsell, WF, Flick, P, Parmer, R et al. Targeted chemoradiation for advanced head and neck cancer. Head Neck 2000;22:687–933.0.CO;2-W>CrossRefGoogle ScholarPubMed
21Samant, S, Robbins, KT, Vang, M, Wan, J, Robertson, J. Intra-arterial cisplatin and concomitant radiation therapy followed by surgery for advanced paranasal sinus cancer. Arch Otolaryngol Head Neck Surg 2004;130:948–55Google Scholar
22Fujishiro, Y, Nakao, K, Watanabe, K, Ebihara, Y, Nakamura, N, Mori, H et al. A new aspect of tri-modal therapy with superselective intra-arterial chemotherapy in maxillary sinus carcinoma. Acta Otolaryngol Suppl 2007;559:151–6CrossRefGoogle Scholar
23Shiga, K, Yokoyama, J, Hashimoto, S, Saijo, S, Tateda, M, Ogawa, T et al. Combined therapy after superselective arterial cisplatin infusion to treat maxillary squamous cell carcinoma. Otolaryngol Head Neck Surg 2007;136:1003–9Google Scholar
24Wang, PC, Tu, TY, Liu, KD. Cystic brain necrosis and temporal bone osteoradionecrosis after radiotherapy and surgery in a patient with ear carcinoma. J Chin Med Assoc 2004;67:487–91Google Scholar
25Wang, CC, Doppke, MS. Osteoradionecrosis of the temporal bone – consideration of nominal standard dose. Int J Radiat Oncol Biol Phys 1976;1:881–3CrossRefGoogle ScholarPubMed
26Pemberton, LS, Swindell, R, Sykes, AJ. Primary radical radiotherapy for squamous cell carcinoma of the middle ear and external auditory canal. Clin Oncol 2006;18:390–4CrossRefGoogle Scholar
27Nadol, JB, Schuknecht, HF. Obliteration of the mastoid in the treatment of tumors on the temporal bone. Ann Otol Rhinol Laryngol 1984;93:6–12Google Scholar
28Moretti, JA. Sensori-neural hearing loss following radiation therapy to the nasopharynx. Laryngoscope 1976;86:598–602CrossRefGoogle Scholar
29Grau, C, Moller, K, Overgaard, M, Overgaard, J, Elbrond, O. Auditory brain stem responses in patients after radiation therapy for nasopharyngeal carcinoma. Cancer 1992;70:2396–401Google Scholar
30Pan, CC, Eisbruch, A, Lee, JS, Snorrason, RM, Haken, RKT, Kileny, PR. Prospective study of inner ear radiation dose and hearing loss in head-neck cancer patients. Int J Radiat Oncol Biol Phys 2005;61:1393–402CrossRefGoogle Scholar
31Kun, LE, Thompson, JW, Gould, HJ, Stocks, RMS. Hearing loss as a late complication of radiotherapy in children with brain tumors. Ann Otol Rhinol Laryngol 2005;114:328–31Google Scholar
32Ho, WK, Wei, WI, Kwong, DL. Long-term sensorineural hearing deficit following radiotherapy in patients suffering from nasopharyngeal carcinoma: A prospective study. Head Neck 1999;21:547–53Google Scholar
33Schot, LJ, Hilgers, FJM, Keus, RB, Schouwenburg, PF, Dreschler, WA. Late effects of radiotherapy on hearing. Eur Arch Otorhinolaryngol 1992;249:305–8CrossRefGoogle ScholarPubMed