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Successful treatment of rhinocerebral mucormycosis by a combination of aggressive surgical debridement and the use of systemic liposomal amphotericin B and local therapy with nebulized amphotericin – a case report

Published online by Cambridge University Press:  29 June 2007

P. Raj ,
E. J. Vella  and
R.C. Bickerton
P. Raj*
Affiliation:
Department of Otolaryngology, Warwick Hospital, Lakin Road, Warwick, UK.
E. J. Vella
Affiliation:
Department of Pathology, Warwick Hospital, Lakin Road, Warwick, UK.
R.C. Bickerton
Affiliation:
Department of Otolaryngology, Warwick Hospital, Lakin Road, Warwick, UK.
*
Address for correspondence:Mr P. Raj, 8 Warner Close, Warwick, CV34 5NE.
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Abstract

A case of mucormycosis involving the nose and paranasalsinuses in a 55-year-old man with recently diagnosed acute promyelocytic leukaemia is reported. It was successfully treated with a combination of aggressive surgical debridement and systemic amphotericin B. In addition, local nebulized amphotericin B was used as an adjunct totherapy. We believe this is only the second documented use of nebulized amphotericin in the management of sinonasal mucormycosis. The needfor a high index of suspicion and early aggressive management is emphasized.

Keywords

Mucormycosis, rhinocerebralAntifungal agentsParanasal sinuses, Surgery
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 4 , April 1998 , pp. 367 - 370
Copyright
Copyright © JLO (1984) Limited 1998

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