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Successful treatment of intranasal papillomata with imiquimod cream in a human immunodeficiency virus positive patient

Published online by Cambridge University Press:  19 May 2008

A Fernández-Casado ,
R M Pujol ,
M Amat  and
F Gallardo
A Fernández-Casado
Affiliation:
Department of Dermatology, Hospital del Mar-IMAS (Institut Municipal d'Assistència Sanitària), Barcelona, Spain
R M Pujol*
Affiliation:
Department of Dermatology, Hospital del Mar-IMAS (Institut Municipal d'Assistència Sanitària), Barcelona, Spain
M Amat
Affiliation:
Department of Otorhinolaryngology, Hospital del Mar-IMAS (Institut Municipal d'Assistència Sanitària), Barcelona, Spain
F Gallardo
Affiliation:
Department of Dermatology, Hospital del Mar-IMAS (Institut Municipal d'Assistència Sanitària), Barcelona, Spain
*
Address for correspondence: Dr Ramon M Pujol, Department of Dermatology, Hospital del Mar-IMAS, Passeig Marítim 25-29, 08003 Barcelona, Spain. Fax: 0034 932483328 E-mail: [email protected]
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Abstract

Objectives:

To report a new, alternative treatment for nasal papillomata in human immunodeficiency virus positive patients with multiple recurrences after surgical removal.

Case report:

A human immunodeficiency virus positive patient presented with multiple, recurrent nasal papillomata which developed after repeated surgical removal procedures. In this patient, complete and persistent resolution of the lesions was achieved after topical treatment with imiquimod cream.

Conclusion:

Imiquimod is a class of non-nucleoside imidazoquinolinamines which promotes local cytokine release from antigen-presenting cells inducing a T-h1 dominant cell-mediated response against virus-infected cells. Topical imiquimod 5 per cent cream, applied for four to 16 weeks, may offer some benefit in the management of recurrent nasal papillomata in human immunodeficiency virus positive patients. Such treatment may be preferable to surgery or destructive therapeutic options when patients are unwilling or are poor surgical candidates, and also avoids potential surgical sequelae such as scar formation and stenosis.

Keywords

ImiquimodPapillomaNasal CavityHIV
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 2 , February 2009 , pp. 240 - 242
Copyright
Copyright © JLO (1984) Limited 2008

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