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Spasmodic dysphonia: a seven-year audit of dose titration and demographics in the Indian population

Published online by Cambridge University Press:  07 July 2014

N K Nerurkar  and
T P Banu
N K Nerurkar*
Affiliation:
Department of ENT, Bombay Hospital, Mumbai, India
T P Banu
Affiliation:
Department of ENT, Bombay Hospital, Mumbai, India
*
Address for correspondence:Dr Nupur Kapoor Nerurkar, D-603 Simla House, Napean Sea Road, Mumbai – 400026, Maharashtra, India E-mail: [email protected]
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Abstract

Objectives:

This study aimed to evaluate the demographics of spasmodic dysphonia in the Indian population and to analyse the optimum dose titration of botulinum toxin type A in this group. A comparative analysis with international studies was also performed.

Method:

The study involved a retrospective analysis and audit of botulinum toxin type A dose titration in spasmodic dysphonia patients who visited our voice clinic between January 2005 and January 2012.

Results:

The average total therapeutic dose required for patients with adductor spasmodic dysphonia was 4.2 U per patient per vocal fold (total 8.4 U per patient), and for patients with abductor spasmodic dysphonia, it was 4.6 U per patient.

Conclusion:

Our audit revealed that 80 per cent of the spasmodic dysphonia patients were male, which contrasts dramatically with international studies, wherein around 80 per cent of spasmodic dysphonia patients were female. Our study also revealed a higher dose titration of botulinum toxin for the Indian spasmodic dysphonia population in both adductor and abductor spasmodic dysphonia cases.

Keywords

DysphoniaLarynxVoice DisordersBotulinum Toxin
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 7 , July 2014 , pp. 649 - 653
Copyright
Copyright © JLO (1984) Limited 2014 

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Footnotes

Presented as a poster (and awarded the David Howard prize for best poster presentation) at the Laryngology 2012 conference, 1–3 June 2012, Kuala Lumpur, Malaysia.

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