Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-28T08:10:13.239Z Has data issue: false hasContentIssue false
  • English
  • Français

Sodium fluoride in otosclerosis treatment: review

Published online by Cambridge University Press:  18 February 2010

A S Cruise ,
A Singh  and
R E Quiney
A S Cruise*
Affiliation:
Department of Otolaryngology, Royal Free Hospital, London, UK
A Singh
Affiliation:
Department of Otolaryngology, Royal Free Hospital, London, UK
R E Quiney
Affiliation:
Department of Otolaryngology, Royal Free Hospital, London, UK
*
Address for correspondence: Mr A S Cruise, Department of Otolaryngology, Royal Free Hospital, 330 Gray's Inn Road, London WC1X 8DA, UK. Fax: 0207915 1430 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objectives:

To review the current literature on the use of sodium fluoride in the treatment of otosclerosis.

Design:

A literature review was conducted, searching the Medline and PubMed database from 1966 to 2009, using the terms ‘otosclerosis’ and ‘fluoride’. Article abstracts were reviewed and relevant full articles acquired.

Results:

There has been only one double-blind, placebo-controlled trial of the use of sodium fluoride in otosclerosis patients, and this found a reduced incidence of deterioration in hearing after two years in the treatment group. Several case–control series have described a hearing benefit in the sodium fluoride treated group. Treatment doses vary greatly, and there is no evidence regarding the optimum duration of treatment.

Conclusions:

There is low quality evidence suggesting that sodium fluoride may be of benefit to preserve hearing and reduce vestibular symptoms in patients with otosclerosis.

Keywords

OtosclerosisSodium FluorideHearing Loss
Type
Review Articles
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 6 , June 2010 , pp. 583 - 586
Copyright
Copyright © JLO (1984) Limited 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Shambaugh, GE Jr, Scott, A. Sodium fluoride for arrest of otosclerosis. Arch Otolaryngol 1964;80:263–70Google ScholarPubMed
2 Causse, JR, Uriel, J, Berges, J, Shambaugh, GE Jr, Bretlau, P, Causse, JB. The enzymatic mechanism of the otospongiotic disease and NaF action on the enzymatic balance. Am J Otol 1982;3:297–314Google ScholarPubMed
3 Linthicum, FH Jr, House, HP, Althaus, SR. The effect of sodium fluoride on otosclerotic activity as determined by strontium. Ann Otol Rhinol Laryngol 1973;82:609–15CrossRefGoogle ScholarPubMed
4 Bretlau, P, Hansen, HJ, Causse, J, Causse, JB. Otospongiosis: morphologic and microchemical investigation after NaF treatment. Otolaryngol Head Neck Surg 1981;89:646–50CrossRefGoogle ScholarPubMed
5 Derks, W, De Groot, JA, Raymakers, JA, Veldman, JE. Fluoride therapy for cochlear otosclerosis? An audiometric and computerized tomography evaluation. Acta Otolaryngol 2001;121:174–7Google ScholarPubMed
6 Colletti, V, Fiorino, FG. Effect of sodium fluoride on early stages of otosclerosis. Am J Otol 1991;12:195–8Google ScholarPubMed
7 Forquer, MS, Linthicum, FH, Bennett, C. Sodium fluoride: effectiveness of treatment for cochlear otosclerosis. Am J Otol 1986;7:121–5Google ScholarPubMed
8 Bretlau, P, Causse, J, Causse, JB, Hansen, HJ, Johnsen, NJ, Salomon, G. Otospongiosis and sodium fluoride. A blind experimental and clinical evaluation of the effect of sodium fluoride treatment in patients with otospongiosis. Ann Otol Rhinol Laryngol 1985;94:103–7CrossRefGoogle ScholarPubMed
9 Browning, GG, Gatehouse, S. The prevalence of middle ear disease in the adult British population. Clin Otolaryngol Allied Sc 1992;17:317–21CrossRefGoogle ScholarPubMed
10 Van Wagoner, RS, Campbell, JD. The use of electro-acoustic impedance measurements in detecting early clinical otosclerosis. J Otolaryngol 1976;5:33–6Google ScholarPubMed
11 Shambaugh, GE Jr. How and when to prescribe sodium fluoride. Am J Otol 1989;10:146–7Google ScholarPubMed
12 Naumann, IC, Porcellini, B, Fisch, U. Otosclerosis: incidence of positive findings on high-resolution computed tomography and their correlation to audiological test data. Ann Otol Rhinol Laryngol 2005;114:709–16CrossRefGoogle ScholarPubMed
13 Causse, JR, Causse, JB. Otospongiosis as a genetic disease. Early detection, medical management, and prevention. Am J Otol 1984;5:211–23Google ScholarPubMed
14 Freeman, J. Otosclerosis and vestibular dysfunction. Laryngoscope 1980;90:1481–7CrossRefGoogle ScholarPubMed
15 e-Digest Statistics about: Inland Water Quality and Use. In: http://www.defra.gov.uk/evidence/statistics/environment/inlwater/iwfluoride.htm [15 Nov 2009]Google Scholar
16 Vartiainen, E, Vartiainen, J. The effect of drinking water fluoridation on the natural course of hearing in patients with otosclerosis. Acta Otolaryngol 1996;116:747–50CrossRefGoogle ScholarPubMed
17 Das, TK, Susheela, AK, Gupta, IP, Dasarathy, S, Tandon, RK. Toxic effects of chronic fluoride ingestion on the upper gastrointestinal tract. J Clin Gastroenterol 1994;18:194–9CrossRefGoogle ScholarPubMed
18 Deka, RC, Kacker, SK, Shambaugh, GE Jr. Intestinal absorption of fluoride preparations. Laryngoscope 1978;88:1918–21CrossRefGoogle ScholarPubMed