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Seroprevalence of Helicobacter pylori infection in patients with chronic nonspecific pharyngitis: preliminary study

Published online by Cambridge University Press:  13 March 2007

İ Aladag ,
Y Bulut ,
M Guven ,
A Eyibilen  and
K Yelken
İ Aladag*
Affiliation:
Departments of ORL and Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey
Y Bulut
Affiliation:
Departments of ORL and Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey Microbiology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey
M Guven
Affiliation:
Departments of ORL and Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey
A Eyibilen
Affiliation:
Departments of ORL and Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey
K Yelken
Affiliation:
Departments of ORL and Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey
*
Address for correspondence: Professor İbrahim Aladag, Department of Otorhinolaryngology, Medical Faculty, Gaziosmanpasa University, Tokat, Turkey. Fax: 90 356 213 31 79 E-mail: [email protected]
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Abstract

Background and objectives:

Chronic nonspecific pharyngitis is a chronic inflammation of the pharynx. It is found worldwide, and treatment is difficult. The underlying aetiopathogenesis is still controversial. The aim of this study was to investigate Helicobacter pylori seroprevalence in chronic nonspecific pharyngitis patients without other possible causative factors for chronic pharyngeal irritation and without H pylori gastric mucosal infection.

Materials and methods:

Forty-one patients with symptoms of chronic nonspecific pharyngitis and 30 healthy control subjects were enrolled in this prospective, controlled, clinical study. In both study and control groups, selected patients were shown to have gastric mucosa uninfected by H pylori, as demonstrated by the 14C-urea breath test. Comprehensive otorhinolaryngological examination did not elicit any factor contributing to the chronic pharyngeal complaint. Serum H pylori immunoglobulin G antibody titres were assayed using serum enzyme-linked immunosorbent assay. The difference between the study and control groups was analysed by the chi-square test (the likelihood ratio was used).

Results:

Thirty-two of the 41 patients (78 per cent) and 14 of the 30 control subjects (46.7 per cent) were found to be H pylori positive. Patients with chronic nonspecific pharyngitis were found to have a significantly higher rate of H pylori seropositivity than the control group (p = 0.016).

Conclusion:

These data may be important in developing future treatment strategies for chronic nonspecific pharyngitis.

Keywords

PharyngitisHelicobacter Pylori
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 1 , January 2008 , pp. 61 - 64
Copyright
Copyright © JLO (1984) Limited 2007

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References

1Marshall, BJ, Warren, JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984;16:1311–15Google Scholar
2Megraud, F. Epidemiology of Helicobacter pylori infection. Gastroenterol Clin North Am 1993;22:73–88CrossRefGoogle ScholarPubMed
3Gasbarrini, A, Franceschi, F, Armuzzi, A, Ojetti, V, Candelli, M, Torre, ES et al. Extradigestive manifestations of Helicobacter pylori gastric infection. Gut 1999;45:9–12CrossRefGoogle ScholarPubMed
4Oshowo, A, Gillam, D, Botha, A, Tunio, M, Holton, J, Boulos, P et al. Helicobacter pylori: the mouth, stomach, and gut axis. Ann Periodontol 1998;3:276–80CrossRefGoogle ScholarPubMed
5Song, Q, Lange, T, Spahr, A, Adler, G, Bode, G. Characteristic distribution pattern of Helicobacter pylori in dental plaque and saliva detected with nested PCR. J Med Microbiol 2000;49:349–53CrossRefGoogle ScholarPubMed
6Unver, S, Kubilay, U, Sezen, OS, Coskuner, T. Investigation of Helicobacter pylori colonization in adenotonsillectomy specimens by means of the CLO test. Laryngoscope 2001;111:2183–6Google Scholar
7Mitz, HS, Farber, SS. Demonstration of Helicobacter pylori in tracheal secretions. J Am Osteopath Assoc 1993;93:87–91Google Scholar
8Roussos, A, Tsimpoukas, F, Anastasakou, E, Alepopoulou, D, Paizis, I, Philippou, N. Helicobacter pylori seroprevalence in patients with chronic bronchitis. J Gastroenterol 2002;37:332–5CrossRefGoogle ScholarPubMed
9Tsang, KW, Lam, SK, Lam, WK, Karlberg, J, Wong, BC, Hu, WH et al. High seroprevalence of Helicobacter pylori in active bronchiectasis. Am J Respir Crit Care Med 1998;158:1047–51CrossRefGoogle ScholarPubMed
10Unal, M, Ozturk, L, Ozturk, C, Kabal, A. The seroprevalence of Helicobacter pylori infection in patients with obstructive sleep apnoea: a preliminary study. Clin Otolaryngol Allied Sci 2003;28:100–2CrossRefGoogle ScholarPubMed
11Merrill, B, Kelsberg, G, Jankowski, TA, Danis, P. Clinical inquiries. What is the most effective diagnostic evaluation of streptococcal pharyngitis? J Fam Pract 2004;53:734–40Google ScholarPubMed
12Us, D, Hascelik, G. Seroprevalence of Helicobacter pylori infection in an asymptomatic Turkish population. J Infect 1998;37:148–50Google Scholar
13Zhang, JP, Peng, ZH, Zhang, J, Zhang, XH, Zheng, QY. Helicobacter pylori infection in the pharynx of patients with chronic pharyngitis detected with TDI-FP and modified Giemsa stain. World J Gastroenterol 2006;12:468–72CrossRefGoogle ScholarPubMed
14Crabtree, JE. Role of cytokines in pathogenesis of Helicobacter pylori-induced mucosal damage. Dig Dis Sci 1998;43:46–55Google ScholarPubMed
15Nelson, S, Summer, WR, Mason, CM. The role of the inflammatory response in chronic bronchitis: therapeutic implications. Semin Respir Infect 2000;15:24–31CrossRefGoogle ScholarPubMed
16Silva, JR, Jones, JA, Cole, PJ, Poulter, LW. The immunological component of the cellular inflammatory infiltrate in bronchiectasis. Thorax 1989;44:668–73CrossRefGoogle ScholarPubMed
17Epple, HJ, Kirstein, FW, Bojarski, C, Frege, J, Fromm, M, Riecken, EO et al. 13C-urea breath test in Helicobacter pylori diagnosis and eradication. Correlation to histology, origin of ‘false’ results, and influence of food intake. Scand J Gastroenterol 1997;32:308–14CrossRefGoogle ScholarPubMed