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Salvage surgery following irradiation with different fractionation regimes in the treatment of carcinoma of the laryngo pharynx: experience gained from a British Institute of Radiology Study

Published online by Cambridge University Press:  29 June 2007

C. J. Alcock ,
J. F. Fowler ,
J. L. Haybittle ,
J. W. Hopewell ,
M. Rezvani  and
G. Wiernik
C. J. Alcock
Affiliation:
Department of Radiotherapy & Oncology, The Churchill Hospital, Headington, Oxford OX3 7LJ, UK.
J. F. Fowler
Affiliation:
Human Oncology, K4/336, 600 Highland Avenue, Madison, W153792, U.S.A.
J. L. Haybittle
Affiliation:
M.R.C. Cancer Trials Office. 7 Green Street, Cambridge, CB2 3JU, U.K.
J. W. Hopewell
Affiliation:
Research Institute (University of Oxford), The Churchill Hospital, Headington, Oxford, OX3 7LJ, U.K.
M. Rezvani
Affiliation:
Research Institute (University of Oxford), The Churchill Hospital, Headington, Oxford, OX3 7LJ, U.K.
G. Wiernik
Affiliation:
Research Institute (University of Oxford), The Churchill Hospital, Headington, Oxford, OX3 7LJ, U.K.
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Abstract

The 10-year follow-up of patients in a clinical trial involving the comparison of treatment by three fractions per week versus five fractions per week in radiotherapy of squamous carcinoma of the larynx and hypopharynx has now been completed. The trial involved an intake of 734 patients between 1966 and 1975. No statistically significant differences have been found between the two trial arms in terms of overall survival, age corrected survival, local recurrence, laryngectomy-free rates or effects on the normal tissues. Local recurrence was found in 320 of the 713 evaluable patients (45 per cent). Salvage laryngectomy was performed in 151 of the 320 patients with recurrence (47 per cent). Survival at 10 years for all node negative patients was 50 per cent in those patients without primary recurrence, compared with 40 per cent in those undergoing salvage laryngectomy.

Keywords

Laryngeal neoplasmsRadiotherapyLaryngectomy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 2 , February 1992 , pp. 147 - 153
Copyright
Copyright © JLO (1984) Limited 1992

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