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Salivary neoplasms of the palate: a flow cytometric and clinicopathological analysis

Published online by Cambridge University Press:  29 June 2007

Rosario Carrillo ,
John G. Batsakis ,
Randal Weber ,
Mario A. Luna  and
Adel K. El-Naggar
Rosario Carrillo
Affiliation:
Department of Anatomic Pathology, Hospital Ramony Cajal, Madrid, Spain, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
John G. Batsakis*
Affiliation:
Department of the Departments of Pathology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Randal Weber
Affiliation:
Department of Head and Neck Surgery, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Mario A. Luna
Affiliation:
Department of the Departments of Pathology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Adel K. El-Naggar
Affiliation:
Department of the Departments of Pathology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
*
John G. Batsakis, M.D., The University of Texas, M.D. Anderson Cancer Center, Department of Pathology,1515 Holcombe Blvd., Box 85, Houston, Texas 77030.
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Abstract

In order to test the clinical and prognostic significance of flow cytometrically assessed DNA content in minor salivary gland tumours we evaluated 75 neoplasms of the palate, 55 of which were carcinomas. Benign neoplasms were exclusively DNA diploid with low S-phase fractions while 22 per cent of malignant tumours manifested a DNA aneuploidy and 23.5 per cent high S-phase fractions (>5 per cent). Significant statistical correlations between DNA content and tumour size, histological grade, lymph node metastasis and lethality were observed. Our findings suggest a potentially important role for flow-cytometry in the evaluation of these neoplasms.

Keywords

Flow cytometryDNASalivary gland neoplasmsPalateAdenocarcinoma, terminal ductCarcinoma, adenoid cystic
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 9 , September 1993 , pp. 858 - 861
Copyright
Copyright © JLO (1984) Limited 1993

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