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Role of mitomycin C in reducing keloid recurrence: patient series and literature review

Published online by Cambridge University Press:  19 October 2010

M Gupta  and
T Narang
M Gupta*
Affiliation:
Department of ENT, Gian Sagar Medical College and Hospital, Ram Nagar, Banur, Distt Patiala, Punjab, India
T Narang
Affiliation:
Department of Dermatology, Gian Sagar Medical College and Hospital, Ram Nagar, Banur, Distt Patiala, Punjab, India
*
Address for correspondence: Dr Manish Gupta, 1217 Govt Medical College & Hospital Campus, Sector 32-B, Chandigarh 160030, India E-mail: [email protected]
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Abstract

Objective:

To study the role of mitomycin C in reducing keloid recurrence.

Study design:

Prospective, randomised, controlled trial.

Setting:

Tertiary care referral centre.

Patients:

Case series of 20 patients presenting with 26 pinna swellings, mostly following ear piercing.

Interventions:

We used the technique of surgical shave excision combined with topical application of mitomycin C and secondary wound healing, in all 26 pinnae.

Results:

Patients were followed up six to 24 months post-operatively. No recurrences were noted during this period.

Conclusion:

Keloids are fibrotic lesions resulting from abnormal wound healing. The uncontrolled proliferation of normal tissue healing processes results in scarring that enlarges well beyond the original wound margins. Successful treatment of keloids remains a challenge because this disease process has a high propensity for recurrence. Various therapies have previously been reported, and success rates are highly variable. We believe that shave excision followed by topical mitomycin C application is a promising treatment option for the management of pinna keloids.

Keywords

KeloidExternal EarMitomycin C
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 3 , March 2011 , pp. 297 - 300
Copyright
Copyright © JLO (1984) Limited 2010

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References

1Bock, O, Schmid-Ott, G, Malewski, P, Mrowietz, U. Quality of life of patients with keloid and hypertrophic scarring. Arch Dermatol Res 2006;297:433–8CrossRefGoogle ScholarPubMed
2Bailey, JN, Waite, AE, Clayton, WJ, Rustin, MH. Application of topical mitomycin C to the base of shave-removed keloid scars to prevent their recurrence. Br J Dermatol 2007;156:682–6CrossRefGoogle Scholar
3Al-Attar, A, Mess, S, Thomassen, JM, Kauffman, CL, Davison, SP. Keloid pathogenesis and treatment. Plast Reconstr Surg 2006;117:286–300CrossRefGoogle ScholarPubMed
4Stucker, FJ, Hoasjoe, DK, Aarstad, RF eds. Current Therapy in Otolaryngology – Head and Neck Surgery, 5th edn.St Louis: Mosby Yearbook, 1994;113–18Google Scholar
5Stucker, FJ, Goco, PE. The treatment of hypertrophic scars and keloids. Facial Plast Surg Clin North Am 1998;6:191–4CrossRefGoogle Scholar
6Botwood, N, Lewanski, C, Lowdell, C. The risks of treating keloids with radiotherapy. Br J Radiol 1999;72:1222–4Google Scholar
7Gupta, M, Motwani, G. Role of mitomycin C in reducing adhesion formation following endoscopic sinus surgery. J Laryngol Otol 2006;120:921–3CrossRefGoogle ScholarPubMed
8Simman, R, Alani, H, Williams, F. Effect of mitomycin C on keloid fibroblasts: an in vitro study. Ann Plast Surg 2003;50:71–6CrossRefGoogle ScholarPubMed
9Talmi, YP, Orenstein, A, Wolf, M, Kronenberg, J. Use of mitomycin C for treatment of keloid: a preliminary report. Otolaryngol Head Neck Surg 2005;132:598–601Google Scholar
10Stewart, CE 4thKim, JY. Application of mitomycin C for head and neck keloids. Otolaryngol Head Neck Surg 2006;135:946–50CrossRefGoogle ScholarPubMed
11Sanders, KW, Gage-White, L, Stucker, FJ. Topical mitomycin C in the prevention of keloid scar recurrence. Arch Facial Plast Surg 2005;7:172–5Google Scholar