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Role of methicillin-resistant Staphylococcus aureus in head and neck infections

Published online by Cambridge University Press:  11 August 2009

I Brook
I Brook*
Affiliation:
Departments of Pediatrics and Medicine, Georgetown University School of Medicine, Washington DC, USA
*
Address for correspondence: Dr Itzhak Brook, 4431 Albemarle St NW, Washington DC 20016, USA. E-mail: [email protected]
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Abstract

The prevalence of infection with methicillin-resistant Staphylococcus aureus is increasing. Methicillin-resistant Staphylococcus aureus is also being recognised as an important pathogen in head and neck infections. This review summarises studies published over the past two decades which illustrate the growing prevalence of methicillin-resistant Staphylococcus aureus, and the current therapeutic approaches to head and neck infections caused by this bacterium. These infections include sinusitis, otitis, periorbital cellulitis, cervical lymphadenitis, tonsillitis, thyroiditis, retropharyngeal abscess, and abscesses and wounds of the neck. Treatment of head and neck infections associated with methicillin-resistant Staphylococcus aureus includes drainage and debridement, as well as administration of local and systemic antimicrobials that provide coverage against these organisms and against potential aerobic and anaerobic pathogens that may be present if the infection is polymicrobial.

Keywords

Methicillin-Resistant Staphylococcus AureusOtolaryngology
Type
Review Articles
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 12 , December 2009 , pp. 1301 - 1307
Copyright
Copyright © JLO (1984) Limited 2009

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References

1Sakoulas, G, Moellering, RC Jr.Increasing antibiotic resistance among methicillin-resistant Staphylococcus aureus strains. Clin Infect Dis 2008;46(suppl 5):S360–7CrossRefGoogle ScholarPubMed
2Naseri, I, Jerris, RC, Sobol, SE. Nationwide trends in pediatric Staphylococcus aureus head and neck infections. Arch Otolaryngol Head Neck Surg 2009;135:14–16CrossRefGoogle ScholarPubMed
3Suzuki, K, Baba, S, Soyano, K, Kinoshita, H. Experimental and clinical studies of causative bacteria in tonsillitis. Acta Otolaryngol Suppl 1988;454:185–91CrossRefGoogle ScholarPubMed
4Uchizono, A, Ohyama, M, Nishi, J, Yoshinaga, M, Miyata, K, Miyanohara, H et al. Methicillin-resistant Staphylococcus aureus infection in the Kagoshima University Hospital – special attention to prevalence in otolaryngological infectious disease [in Japanese]. Rinsho Byori Japanese 1990;38:998–1004Google ScholarPubMed
5Hwang, JH, Chu, CK, Liu, TC. Changes in bacteriology of discharging ears. J Laryngol Otol 2002;116:686–9CrossRefGoogle ScholarPubMed
6Suzuki, K, Nishimura, T, Baba, S. Current status of bacterial resistance in the otolaryngology field: results from the Second Nationwide Survey in Japan. J Infect Chemother 2003;9:46–52CrossRefGoogle ScholarPubMed
7Yeo, SG, Park, DC, Hong, SM, Cha, CI, Kim, MG. Bacteriology of chronic suppurative otitis media – a multicenter study. Acta Otolaryngol 2007;127:1062–7CrossRefGoogle ScholarPubMed
8Park, DC, Lee, SK, Cha, CI, Lee, SO, Lee, MS, Yeo, SG. Antimicrobial resistance of staphylococcus from otorrhea in chronic suppurative otitis media and comparison with results of all isolated staphylococci. Eur J Clin Microbiol Infect Dis 2008;27:571–7CrossRefGoogle ScholarPubMed
9Martín Salas, C, Gil-Setas, A, Mazón, A. Aetiology and antibiotic sensitivity of the most frequent outpatient infections [in Spanish]. An Sist Sanit Navar 2006;29:27–36Google ScholarPubMed
10Pajor, A, Durko, M, Jankowski, A, Bartoszko-Tyczkowska, A, Stańczyk, R. Bacteriological evaluation in chronic otitis media [in Polish]. Otolaryngol Pol 2006;60:757–63Google ScholarPubMed
11Brook, I, Gober, AE. Recovery of methicillin resistant Staphylococcus aureus and other organisms from spontaneously draining acute otitis media in children before and after the introduction of vaccination with the 7-valent pneumococcal vaccine. Ped Infect Dis J (in press)Google Scholar
12Huang, WH, Hung, PK. Methicillin-resistant Staphylococcus aureus infections in acute rhinosinusitis. Laryngoscope 2006;116:288–91CrossRefGoogle ScholarPubMed
13Brook, I, Foote, PA, Hausfeld, JN. Increase in the frequency of recovery of methicillin-resistant Staphylococcus aureus in acute and chronic maxillary sinusitis. J Med Microbiol 2008;57:1015–17CrossRefGoogle ScholarPubMed
14McKinley, SH, Yen, MT, Miller, AM, Yen, KG. Microbiology of pediatric orbital cellulitis. Am J Ophthalmol 2007;144:497–501CrossRefGoogle ScholarPubMed
15Guss, J, Kazahaya, K. Antibiotic-resistant Staphylococcus aureus in community-acquired pediatric neck abscesses. Int J Pediatr Otorhinolaryngol 2007;71:943–8CrossRefGoogle ScholarPubMed
16Brook, I, Foote, PA. Isolation of methicillin resistant Staphylococcus aureus from the surface and core of tonsils in children. Int J Pediatr Otorhinolaryngol 2006;70:2099–102CrossRefGoogle ScholarPubMed
17Wright, CT, Stocks, RM, Armstrong, DL, Arnold, SR, Gould, HJ. Pediatric mediastinitis as a complication of methicillin-resistant Staphylococcus aureus retropharyngeal abscess. Arch Otolaryngol Head Neck Surg 2008;13:408–13CrossRefGoogle Scholar
18Ossowski, K, Chun, RH, Suskind, D, Baroody, FM. Increased isolation of methicillin-resistant Staphylococcus aureus in pediatric head and neck abscesses. Arch Otolaryngol Head Neck Surg 2006;132:1176–81CrossRefGoogle ScholarPubMed
19Bothwell, NE, Shvidler, J, Cable, BB. Acute rise in methicillin-resistant Staphylococcus aureus infections in a coastal community. Otolaryngol Head Neck Surg 2007;137:942–6CrossRefGoogle Scholar
20Thomason, TS, Brenski, A, McClay, J, Ehmer, D. The rising incidence of methicillin-resistant Staphylococcus aureus in pediatric neck abscesses. Otolaryngol Head Neck Surg 2007;137:459–64CrossRefGoogle ScholarPubMed
21Inman, JC, Rowe, M, Ghostine, M, Fleck, T. Pediatric neck abscesses – changing organisms and empiric therapies. Laryngoscope 2008;118:2111–14CrossRefGoogle ScholarPubMed
22Sugita, R. MRSA infections in otorhinolaryngology [in Japanese]. Nippon Rinsho 1992;50:1127–32Google ScholarPubMed
23Santos, F, Mankarious, LA, Eavey, RD. Methicillin-resistant Staphylococcus aureus: pediatric otitis. Arch Otolaryngol Head Neck Surg 2000;126:1383–5CrossRefGoogle ScholarPubMed
24Kim, ES, Song, JS, Lee, HJ, Choe, PG, Park, KH, Cho, JH et al. A survey of community-associated methicillin-resistant Staphylococcus aureus in Korea. J Antimicrob Chemother 2007;60:1108–14CrossRefGoogle ScholarPubMed
25Laurens, MB, Becker, RM, Johnson, JK, Wolf, JS, Kotloff, KL. MRSA with progression from otitis media and sphenoid sinusitis to clival osteomyelitis, pachymeningitis and abducens nerve palsy in an immunocompetent 10-year-old patient. Int J Pediatr Otorhinolaryngol 2008;72:945–51CrossRefGoogle Scholar
26Mutoh, T, Adachi, O, Tsuji, K, Okunaka, M, Sakagami, M. Efficacy of mastoidectomy on MRSA-infected chronic otitis media with tympanic membrane perforation. Auris Nasus Larynx 2007;34:9–13CrossRefGoogle ScholarPubMed
27Coticchia, JM, Dohar, JE. Methicillin-resistant Staphylococcus aureus otorrhea after tympanostomy tube placement. Arch Otolaryngol Head Neck Surg 2005;131:868–73CrossRefGoogle ScholarPubMed
28Lee, SH, Lee, JE, Baek, WY, Lim, JO. Regional delivery of vancomycin using pluronic F-127 to inhibit methicillin resistant Staphylococcus aureus (MRSA) growth in chronic otitis media in vitro and in vivo. J Control Release 2004;96:1–7CrossRefGoogle ScholarPubMed
29Kashiwamura, M, Chida, E, Matsumura, M, Nakamaru, Y, Suda, N, Terayama, Y et al. The efficacy of Burow's solution as an ear preparation for the treatment of chronic ear infections. Otol Neurotol 2004;25:9–13CrossRefGoogle ScholarPubMed
30Jang, CH, Song, CH, Wang, PC. Topical vancomycin for chronic suppurative otitis media with methicillin-resistant Staphylococcus aureus otorrhoea. J Laryngol Otol 2004;118:645–7CrossRefGoogle ScholarPubMed
31Al-Shawwa, BA, Wegner, D. Trimethoprim-sulfamethoxazole plus topical antibiotics as therapy for acute otitis media with otorrhea caused by community-acquired methicillin-resistant Staphylococcus aureus in children. Arch Otolaryngol Head Neck Surg 2005;131:782–4CrossRefGoogle ScholarPubMed
32Hunt, A, Robb, PJ. Successful treatment of MRSA otorrhoea: a case report. J Laryngol Otol 2006;120:63–4CrossRefGoogle ScholarPubMed
33Brook, I. Recovery of methicillin resistant Staphylococcus aureus from a child with acute otitis media. Pediatr Infect Dis J 2008;27:372–3CrossRefGoogle ScholarPubMed
34Rutar, T, Zwick, OM, Cockerham, KP, Horton, JC. Bilateral blindness from orbital cellulitis caused by community-acquired methicillin-resistant Staphylococcus aureus. Am J Ophthalmol 2005;140:740–2CrossRefGoogle ScholarPubMed
35Gerencer, RZ. Successful outpatient treatment of sinusitis exacerbations caused by community-acquired methicillin-resistant Staphylococcus aureus. Otolaryngol Head Neck Surg 2005;132:828–33CrossRefGoogle ScholarPubMed
36Solares, CA, Batra, PS, Hall, GS, Citardi, MJ. Treatment of chronic rhinosinusitis exacerbations due to methicillin-resistant Staphylococcus aureus with mupirocin irrigations. Am J Otolaryngol 2006;27:161–5CrossRefGoogle ScholarPubMed
37Tabaee, A, Anand, VK, Yoon, C. Outpatient intravenous antibiotics for methicillin-resistant Staphylococcus aureus sinusitis. Am J Rhinol 2007;21:154–8CrossRefGoogle ScholarPubMed
38Anari, S, Karagama, YG, Fulton, B, Wilson, JA. Neonatal disseminated methicillin-resistant Staphylococcus aureus presenting as orbital cellulitis. J Laryngol Otol 2005;119:64–7CrossRefGoogle ScholarPubMed
39Huang, SF, Lee, TJ, Lin, KL. Concomitant bilateral orbital and brain abscesses – unusual complications of pediatric rhinosinusitis. Chang Gung Med J 2005;28:51–5Google ScholarPubMed
40Brook, I. The role of beta-lactamase producing bacteria and bacterial interference in streptococcal tonsillitis. Int J Antimicrob Agents 2001;17:439–42CrossRefGoogle ScholarPubMed
41Lethert, K, Bowerman, J, Pont, A, Earle, K, Garcia-Kennedy, R. Methicillin-resistant Staphylococcus aureus suppurative thyroiditis with thyrotoxicosis. Am J Med 2006;119:e1–2CrossRefGoogle ScholarPubMed
42Elorza, JL, Echenique-Elizonda, M. Acute suppurative thyroiditis. J Am Coll Surg 2002;195:729–30CrossRefGoogle ScholarPubMed
43Constantinides, H, Passant, C, Waddell, AN. Mycotic pseudoaneurysm of common carotid artery mimicking parapharyngeal abscess. J Laryngol Otol 2000;114:796–7CrossRefGoogle ScholarPubMed
44Sato, K, Izumi, T, Toshima, M, Nagai, T, Muroi, K, Komatsu, N et al. Retropharyngeal abscess due to methicillin-resistant Staphylococcus aureus in a case of acute myeloid leukemia. Intern Med 2005;44:346–9CrossRefGoogle Scholar
45Fleisch, AF, Nolan, S, Gerber, J, Coffin, SE. Methicillin-resistant Staphylococcus aureus as a cause of extensive retropharyngeal abscess in two infants. Pediatr Infect Dis J 2007;26:1161–3CrossRefGoogle ScholarPubMed
46Parton, M, Beasley, NJ, Harvey, G, Houghton, D, Jones, AS. Four cases of aggressive MRSA wound infection following head and neck surgery. J Laryngol Otol 1997;111:874–6CrossRefGoogle ScholarPubMed
47Ahmad, I, Lee, WC. Methicillin-resistant Staphylococcus aureus neck infections resulting in a delayed abscess and a tracheo-oesophageal fistula. ORL J Otorhinolaryngol Relat Spec 1999;61:45–7CrossRefGoogle Scholar
48Naidu, SI, Donepudi, SK, Stocks, RM, Buckingham, SC, Thompson, JW. Methicillin-resistant Staphylococcus aureus as a pathogen in deep neck abscesses: a pediatric case series. Int J Pediatr Otorhinolaryngol 2005;69:1367–71CrossRefGoogle ScholarPubMed
49Fong, SM, Watson, M. Lemierre syndrome due to non-multiresistant methicillin- resistant Staphylococcus aureus. J Paediatr Child Health 2002;38:305–7CrossRefGoogle ScholarPubMed
50Boga, C, Ozdogu, H, Diri, B, Oguzkurt, L, Asma, S, Yeral, M. Lemierre syndrome variant: Staphylococcus aureus associated with thrombosis of both the right internal jugular vein and the splenic vein after the exploration of a river cave. J Thromb Thrombolysis 2007;23:151–4CrossRefGoogle ScholarPubMed
51Kadviharan, T, Paramasivan, P, Bangs, A, Banga, A, Gupta, R, Sharma, SK. Lemierre's syndrome due to community-acquired methicillin-resistant Staphylococcus aureus infection and presenting with orbital cellulitis: a case report. Journal of Medical Case Reports 2008;2:374–7Google Scholar
52Boyce, JM. Understanding and controlling methicillin-resistant Staphylococcus aureus infections. Infec Control Hosp Epidemiol 2002;23:485–7CrossRefGoogle ScholarPubMed
53Schneider-Lindner, V, Delaney, JA, Dial, S, Dascal, A, Suissa, S. Antimicrobial drugs and community-acquired methicillin-resistant Staphylococcus aureus, United Kingdom. Emerg Infect Dis 2007;13:994–1000CrossRefGoogle ScholarPubMed
54Howden, BP, Johnson, PD, Ward, PB, Stinear, TP, Davies, JK. Isolates with low-level vancomycin resistance associated with persistent methicillin-resistant Staphylococcus aureus bacteremia. Antimicrob Agents Chemother 2006;50:3039–47CrossRefGoogle ScholarPubMed
55Dombrowski, JC, Winston, LG. Clinical failures of appropriately-treated methicillin-resistant Staphylococcus aureus infections. J Infect 2008;57:110–15CrossRefGoogle ScholarPubMed
56Clements, A, Halton, K, Graves, N, Pettitt, A, Morton, A, Looke, D et al. Overcrowding and understaffing in modern health-care systems: key determinants in methicillin-resistant Staphylococcus aureus transmission. Lancet Infect Dis 2008;8:427–34CrossRefGoogle Scholar
57Jensen, JU, Jensen, ET, Larsen, AR, Meyer, M, Junker, L, Rønne, T et al. Control of methicillin-resistant Staphylococcus aureus (MRSA) outbreak in a day-care institution. J Hosp Infect 2006;63:84–92CrossRefGoogle Scholar
58Boyce, JM. MRSA patients: proven methods to treat colonization. J Hosp Infect 2001;48 (suppl A):S9–14CrossRefGoogle ScholarPubMed
59Harbarth, S, Dharan, S, Liassine, N, Pascale, H, Auckenthaler, R, Pittet, D. Randomized, placebo-controlled, double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 1999;43:1412–16CrossRefGoogle ScholarPubMed
60Simor, AE, Stuart, TL, Louie, L, Watt, C, Ofner-Agostini, M, Gravel, D et al. Canadian Nosocomial Infection Surveillance Program (CNISP). Mupirocin-resistant, methicillin-resistant Staphylococcus aureus (MRSA) in Canadian hospitals. Antimicrob Agents Chemother 2007;51:3880–6CrossRefGoogle Scholar
61Jones, JC, Rogers, TJ, Brookmeyer, P, Dunne, WM Jr, Storch, GA, Coopersmith, CM et al. Mupirocin resistance in patients colonized with methicillin-resistant Staphylococcus aureus in a surgical intensive care unit. Clin Infect Dis 2007;45:541–7CrossRefGoogle Scholar
62Anon, JB, Hadley, JA, Craig, WA, Poole, MD, Ambrose, PG, Benninger, MSAntimicrobial treatment guidelines for acute bacterial rhinosinusitis. Otolaryngol Head Neck Surg 2004;130(suppl 1):1–45Google ScholarPubMed
63Benninger, MS, Payne, SC, Ferguson, BJ, Hadley, JA, Ahmad, N. Endoscopically directed middle meatal cultures versus maxillary sinus taps in acute bacterial maxillary rhinosinusitis: a meta-analysis. Otolaryngol Head Neck Surg 2006;134:3–9CrossRefGoogle ScholarPubMed