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Risk of contamination of lidocaine hydrochloride and phenylephrine hydrochloride topical solution: in vivo and in vitro analyses

Published online by Cambridge University Press:  30 July 2013

M Jog ,
R Sachidananda  and
K Saeed
M Jog*
Affiliation:
Department of Otolaryngology, Hampshire Hospitals NHS Foundation Trust, Royal Hampshire County Hospital, Winchester, UK
R Sachidananda
Affiliation:
Department of Otolaryngology, Hampshire Hospitals NHS Foundation Trust, Royal Hampshire County Hospital, Winchester, UK
K Saeed
Affiliation:
Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Royal Hampshire County Hospital, Winchester, UK
*
Address for correspondence: Mr M Jog, Department of Otolaryngology, Royal Hampshire County Hospital, Winchester SO22 5DG, UK Fax: 01962 824429 E-mail: [email protected]
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Abstract

Objective:

To investigate the risk of contamination of lidocaine hydrochloride 5 per cent weight/volume and phenylephrine hydrochloride 0.5 per cent weight/volume topical solution, both in patients (in vivo) and in the laboratory setting (in vitro).

Methods:

This paper reports a prospective study involving 10 samples of the lidocaine hydrochloride and phenylephrine hydrochloride topical anaesthetic spray. The samples were assessed for microbiological contamination after a single use on patients in a controlled laboratory environment. Additional samples were assessed for baseline contamination and later assessed for contamination in an in vitro setting.

Results:

In the in vivo setting, 2 of the 10 samples were positive for cultures from both the pump and the bottles. However, in the in vitro setting, the pump and the contents of the bottles were contaminated after a single use when the sterile solution was sprayed from distances of 1 and 2 cm.

Conclusion:

The lidocaine hydrochloride and phenylephrine hydrochloride topical solution assembly was contaminated in both in vivo and in vitro settings after a single use.

Keywords

Anesthetics, LocalCross InfectionLidocainePhenylephrineEndoscopyDrug Contamination
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 8 , August 2013 , pp. 799 - 801
Copyright
Copyright © JLO (1984) Limited 2013 

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