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Rhinosporidiosis: immunohistochemical and electron microscopic studies

Published online by Cambridge University Press:  29 June 2007

Bahram Azadeh ,
Nina Baghoumian  and
Osama T. El-Bakri
Bahram Azadeh*
Affiliation:
Department of Pathology, Hamad General Hospital, Doha, State of Qatar.
Nina Baghoumian
Affiliation:
Department of Pathology, Hamad General Hospital, Doha, State of Qatar.
Osama T. El-Bakri
Affiliation:
Department of ENT, Hamad General Hospital, Doha, State of Qatar.
*
Dr B. Azadeh, Breast Pathology Unit, Southmead Hospital, Bristol, BS10 5NB. Fax: 0272 509690.
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Abstract

Sixteen biopsies of rhinosporidiosis (15 nasal and one conjunctival) from 16 Southern Indian male immigrant workers showed mucosal lymphoplasmacellular infiltrates together with transepithelial elimination of nodular bodies and destruction of some late stage nodular bodies in histiocytic granulomata with central neutrophilic microabscesses. Early nodular bodies were immunohistochemically positive for alpha1-AT, alpha1-ACT, CEA, S100, fibronectin, amyloid-p-component, IgG, IgA, CIq and C3. Electron microscopy showed organized

concentric lamellated bodies in early nodular bodies and not in end-stage nodular bodies which contained mostly amorphous electron dense materials. Structures formerly regarded as ‘sporangia’ and ‘spores’ are believed to be lysosomal bodies loaded with indigestible residues to be cleared via transepithelial elimination or segregated/destroyed by secondary immune/granulomatous responses.

Keywords

RhinosporidiosisLysosomesImmunohistochemistryMicroscopy, electron
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 108 , Issue 12 , December 1994 , pp. 1048 - 1054
Copyright
Copyright © JLO (1984) Limited 1994

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