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The response of adenoid cystic carcinoma to tamoxifen

Published online by Cambridge University Press:  29 June 2007

A. Shadaba ,
M. N. Gaze  and
H. R. Grant
A. Shadaba*
Affiliation:
Royal National Throat, Nose and Ear Hospital, Gray's Inn Road, London, UK.
M. N. Gaze
Affiliation:
Royal National Throat, Nose and Ear Hospital, Gray's Inn Road, London, UK.
H. R. Grant
Affiliation:
Royal National Throat, Nose and Ear Hospital, Gray's Inn Road, London, UK.
*
Address for correspondence: Ms A. Shadaba, Royal National Throat, Nose and Ear Hospital, 330-332 Gray's Inn Road, London WC1X 8EE.
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Abstract

Adenoid cystic carcinoma of the parotid gland often recurs locally, or metastases develop, after initial treatment with surgery and radiotherapy. We report a patient with an inoperable local recurrence of previously irradiated adenoid cystic carcinoma, who was treated with tamoxifen, an oestrogen receptor antagonist. After 18 months of treatment with tamoxifen, MRI showed a partial response, and further clinical progression of the disease was halted.

Keywords

Parotid neoplasmsCarcinomaadenoid cysticTamoxifen
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 111 , Issue 12 , December 1997 , pp. 1186 - 1189
Copyright
Copyright © JLO (1984) Limited 1997

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References

Azumi, N., Battifora, H. (1987) The cellular composition of adenoid cystic carcinoma: an immunohistologic study. Cancer 60: 1589–1598.3.0.CO;2-U>CrossRefGoogle Scholar
Belson, T. P., Toohill, R. J., Lehman, R. H. (1982) Adenoid cystic carcinoma of the submaxillary gland. Laryngoscope 92: 497–501.CrossRefGoogle ScholarPubMed
Bilroth, T. (1856) Beobachtiergen uber Geschhulate der Spercheldrusen. Archives of Pathology and Anatomy 17: 357.Google Scholar
British National Formulary (1994) Number 28. Published by the Pharmaceutical Press, London, pp 340–341.Google Scholar
Conley, J., Dingham, D. (1974) Adenoid cystic carcinoma inthe head and neck (cylindroma). Archives of Otolaryngology 100: 81–90.CrossRefGoogle Scholar
Conley, J., Casler, J. (1991) Adenoid Cystic Cancer of theHead and Neck. 1st Edition. Thieme Medical Publishers, Inc. New York, pp 23–27.Google Scholar
Cowie, V. J., Pointon, R. C. S. (1984) Adenoid cystic carcinoma of the salivary glands. Clinical Radiology 35: 331–333.CrossRefGoogle ScholarPubMed
Dimey, I. W., Lovell, A. J., Verjan, R. P., Raymond, A. K., Goepfert, H., Hong, W. K. (1987) Estrogen receptors in normal salivary gland and salivary gland carcinoma. Archives ofOtolaryngology–Head and Neck Surgery 113: 1082–1085.CrossRefGoogle Scholar
Karen, K. F., Steven, A., Levine, L. M., Lawrence, M. F., Roger, B., Theodore, L. P. (1977) Carcinoma of the major and minor salivary glands. Cancer 40: 2882–2887.Google Scholar
Kolar, Z., Kodousek, R., Ehrmann, J. Jr., Macak, J., Starek, I., Kucera, J. (1994) Expression of oestrogen receptors and oestrogen induced proteins in tumours of ‘hormone nondependent tissues’. Cesko-Slovenska patalogie 30(1): 12–15.Google ScholarPubMed
Lamey, P. J., Leake, R. E., Cowan, S. K., Soutar, D. S., McGregor, I. A., McGregor, F. M. (1987) Steroid hormone receptors in human salivary gland tumours. Journal of Clinical Pathology 40: 532–534.CrossRefGoogle ScholarPubMed
Leafstedt, S. W., Gaeta, J. F., Sako, K., Marchetta, F. C. (1971) Adenoid cystic carcinoma of major and minor salivary glands.American Journal of Surgery 122: 756–762.CrossRefGoogle ScholarPubMed
Molteni, A., Warpeha, R. L., Brizio-Molteni, L., Sors, E. (1981) Estradiol receptor-binding protein in head and neck neoplastic andnormal tissue. Archives of Surgery 116: 207–210.CrossRefGoogle Scholar
Perzin, K. H., Fullane, P., Clairmont, A. C. (1978) Adenoid cystic carcinoma arising in salivary glands: a correlation of histologic features and clinical course. Cancer 42: 265–282.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed