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Recovery from sensorineural deafness in Wegener's granulomatosis

Published online by Cambridge University Press:  29 June 2007

M. R. Clements ,
C. D. Mistry ,
A. O. Keith  and
R. T. Ramsden
M. R. Clements*
Affiliation:
Lecturer, University Department of Medicine, Royal Infirmary, Manchester
C. D. Mistry
Affiliation:
Senior Registrar, Renal Unit, Royal Infirmary, Manchester
A. O. Keith
Affiliation:
Senior Registrar, University Department of Otolaryngology, Royal Infirmary, Manchester
R. T. Ramsden
Affiliation:
Consultant Otolaryngologist, University Department of Otolaryngology, Royal Infirmary, Manchester.
*
Dr M. R. Clements, M.D., M.R.C.P., University Department of Medicine, Royal Infirmary, Manchester M13 9WL
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Abstract

Wegener's granulomatosis may present with deafness or other aural symptoms. This report describes two patients with histological evidence of Wegener's granulomatosis who developed reversible sensorineural hearing loss during the course of their illness. The first patient showed complete recovery of a sensorineural hearing loss averaging 50 dB after ten months treatment with cyclophosphamide and high-dose prednisolone. The second patient, who was on maintenance haemodialysis, achieved a 40 dB improvement in sensorineural hearing loss within two weeks of adding cyclophosphamide to pre-existing corticosteroid therapy. These findings suggest that the prognosis of sensorineural hearing loss in Wegener's granulomatosis can be improved with suppression of the vasculitic process by early treatment with combined cytotoxic-immunosuppressive therapy

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 5 , May 1989 , pp. 515 - 518
Copyright
Copyright © JLO (1984) Limited 1989

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