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Prospective study of sensorineural hearing loss following radiotherapy for nasopharyngeal carcinoma

Published online by Cambridge University Press:  20 October 2009

J-J Li ,
Y-K Guo ,
Q-L Tang ,
S-S Li ,
X-L Zhang ,
P-A Wu  and
X-M Yang
J-J Li
Affiliation:
Department of Otolaryngology, Head and Neck Surgery and theInstitute of Otology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
Y-K Guo
Affiliation:
Department of Otolaryngology, Head and Neck Surgery and theInstitute of Otology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
Q-L Tang
Affiliation:
Department of Otolaryngology, Head and Neck Surgery and theInstitute of Otology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
S-S Li
Affiliation:
Department of Otolaryngology, Head and Neck Surgery and theInstitute of Otology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
X-L Zhang
Affiliation:
Department of Otolaryngology, Head and Neck Surgery and theInstitute of Otology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
P-A Wu
Affiliation:
Department of Otolaryngology, Head and Neck Surgery and theInstitute of Otology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
X-M Yang*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery and theInstitute of Otology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
*
Address for correspondence: Dr Xin-Ming Yang, Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, PR China. Fax: +86 731 5533525 E-mail: [email protected]
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Abstract

Objectives:

To investigate the severity and incidence of sensorineural hearing loss in patients with nasopharyngeal carcinoma treated with radiotherapy.

Methods:

Forty-two patients with nasopharyngeal carcinoma were treated with conventional radiotherapy. Audiological testing was performed to compare patients' hearing before and at varying stages after radiotherapy.

Results:

At one month post-radiation, a significant hearing threshold increase was seen only for high frequencies. At 12, 24 and 60 months post-radiation, significant threshold increases were observed at speech frequencies (4.0 and 8.0 kHz), compared with pre-radiation data. The mean values of wave I, III and V latencies and of the I–V interpeak latency intervals were not significantly altered at one month post-radiation, but were significantly prolonged at 12, 24 and 60 months post-radiation, compared with pre-radiation data.

Conclusion:

In patients with nasopharyngeal carcinoma treated with radiotherapy, the severity and incidence of radiation-induced sensorineural hearing loss increased with time, especially at high frequencies. This hearing impairment may be due to changes in the cochlea and/or the retrocochlear auditory pathway.

Keywords

NasopharynxCarcinomaRadiation TherapyHearing Loss
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 1 , January 2010 , pp. 32 - 36
Copyright
Copyright © JLO (1984) Limited 2009

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References

1 Ondrey, FG, Greig, JR, Herdcher, L. Radiation dose to otologic structures during head and neck cancer radiation therapy. Laryngoscope 2000;110:217–21Google Scholar
2 Raaijmakers, E, Engelen, AM. Is sensori-neural hearing-loss a possible side effect of nasopharyngeal and parotid irradiation? A systematic review of the literature. Radiother Oncol 2002;65:1–7Google Scholar
3 Bhandare, N, Antonelli, PJ, Morris, CG, Malayapa, RS, Mendenhall, WM. Ototoxicity after radiotherapy for head and neck tumors. Int Radiat Oncol Biol Phys 2007;67:469–79CrossRefGoogle ScholarPubMed
4 Pearson, SE, Meyer, AC, Adams, GL, Ondrey, FG. Decreased hearing after combined modality therapy for head and neck cancer. Am J Otolaryngol 2006;27:76–80CrossRefGoogle ScholarPubMed
5 Wang, LF, Kuo, WR, Ho, KY, Lee, KW, Lin, CS. A long-term study on hearing status in patients with nasopharyngeal carcinoma after radiotherapy. Otol Neurotol 2004;25:168–73Google Scholar
6 Low, WK, Toh, ST, Wee, J, Fook-Chong, SM, Wang, DY. Sensorineural hearing loss after radiotherapy and chemoradiotherapy: a single, blinded, randomized study. J Clin Oncol 2006;24:1904–9Google Scholar
7 Wang, LF, Kuo, WR, Ho, KY, Lee, KW, Lin, CS. Hearing loss in patients with nasopharyngeal carcinoma after chemotherapy and radiation. Kaohsiung J Med Sci 2003;19:163–9CrossRefGoogle ScholarPubMed
8 Jerezek-Fossa, BA, Zarowski, A, Milani, F, Orecchia, R. Radiotherapy-induced ear toxicity. Cancer Treat Rev 2003;29:417–30CrossRefGoogle Scholar
9 Chen, WC, Jackson, A, Budnick, AS, Pfister, DG, Kraus, DH, Hunt, MA et al. Sensorineural hearing loss in combined modality treatment of nasopharyngeal carcinoma. Cancer 2006;106:820–9CrossRefGoogle ScholarPubMed
10 Rosenblatt, E, Brook, OR, Erlich, N, Miller, B, Joachims, HZ, Kuten, A. Late visual and auditory toxicity of radiotherapy for nasopharyngeal carcinoma. Tumori 2003;89:68–74Google Scholar
11 Wolden, SL, Zelefsky, MJ, Kraus, DH, Rosenzweig, KE, Chong, LM, Shaha, AR et al. Accelerated concomitant boost radiotherapy and chemotherapy for advanced nasopharyngeal carcinoma. J Clin Oncol 2001;19:1105–10Google Scholar
12 Johannesen, TB, Rasmussen, K, Winther, FO, Halvorsen, U, Lote, K. Late radiation effects on hearing, vestibular function, and taste in brain tumour patients. Int J Radiat Oncol Biol Phys 2002;53:86–90Google Scholar
13 Ho, WK, Wei, WI, Kwong, DL, Sham, JS, Tai, PT, Yuen, AP et al. Long-term sensorineural hearing deficit following radiotherapy in patients suffering from nasopharyngeal carcinoma: a prospective study. Head Neck 1999;21:547–533.0.CO;2-Y>CrossRefGoogle ScholarPubMed
14 Low, WK, Tan, MG, Sun, L, Chua, AW, Goh, LK, Wang, DY. Dose-dependant radiation-induced apoptosis in a cochlear cell-line. Apoptosis 2006;11:2127–36Google Scholar
15 Bohne, BA, Marks, JE, Glasgow, GP. Delayed effects of ionizing radiation on the ear. Laryngoscope 1985;95:818–28CrossRefGoogle Scholar
16 Kim, CS, Shin, SO. Ultrastructural changes in the cochlea of the guinea pig after fast neutron irradiation. Otolaryngol Head Neck Surg 1994;110:419–27Google Scholar
17 Asenov, DR, Kaga, K, Tsuzuku, T. Changes in the audiograms of a nasopharyngeal cancer patient during the course of treatment: a temporal bone histopathological study. Acta Otolaryngol 2007;127:1105–10Google Scholar
18 Low, WK, Burgess, R, Fong, KW, Wang, DY. Effect of radiotherapy on retro-cochlear auditory pathways. Laryngoscope 2005;115:1823–6CrossRefGoogle ScholarPubMed
19 Lau, SK, Wei, WI, Sham, JS, Choy, DT, Hui, Y. Early changes of auditory brainstem evoked response after radiotherapy for nasopharyngeal carcinoma: a prospective study. J Laryngol Otol 1992;106:887–92CrossRefGoogle ScholarPubMed