Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-28T20:56:33.787Z Has data issue: false hasContentIssue false
  • English
  • Français

Prognosis in mouth cancer: host factors

Published online by Cambridge University Press:  29 June 2007

P. M. Stell
P. M. Stell*
Affiliation:
Liverpool
*
Professor P. M. Stell, 7 Partridge Road, Liverpool 23
Get access Rights & Permissions [Opens in a new window]

Abstract

A personal series of 842 patients with a tumour of the oral cavity is presented. Five hundred and twelve of these patients had a histologically proven squamous cell carcinoma, and were previously untreated.

Increasing age was associated with worsening performance status. Women were older at presentation than men, and tumours of the upper part of the mouth were more common in the elderly, but there was no relation between age and histological grade or stage grouping.

Sex had no correlation with performance status or histological grade. However, men were more likely to have an advanced tumour, and tumours of the floor of the mouth and alveolus were much commoner in men.

There was no correlation between performance status and site or histological grade, but patients in poor general condition were more likely to have stage III-IV tumours.

Multivariate analysis showed that sex had no impact whatever on survival, but survival fell with increasing age and worsening performance status. The effect of age and performance status disappeared when the survival of treated patients was adjusted for deaths due to other causes.

Keywords

Mouth neoplasmsPrognosis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 5 , May 1992 , pp. 399 - 402
Copyright
Copyright © JLO (1984) Limited 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Armitage, P., Berry, G. (1987) Statistical methods in medical research. 2nd edition, Blackwell Scientific Publications: Oxford. p. 436–437.Google Scholar
Beahres, O. H., Henson, D. E., Hutter, R. V., Myers, M. H. A. J. C. manual for staging of cancer, 2nd edition. J. B. Lippincott Company: Philadelphia.Google Scholar
Berthelsen, A., Hansen, H. S., Rygard, J. (1977) Radiation therapy of squamous carcinoma of the floor of the mouth and the lower alveolar ridge. Journal of Laryngology and Otology, 91: 489–499.CrossRefGoogle ScholarPubMed
Binnie, W. H., Cawson, R. A., Hill, G. B., Soaper, A. E. (1972) Oral cancer in England and Wales, London HMSO.Google Scholar
Cox, D. R. (1972) Regression models and life-tables. Journal of the Royal Statistical Society, B34: 187–220.Google Scholar
Easson, E. C., Palmer, M. K. (1976) Prognostic factors in oral cancer. Clinical Oncology, 2: 191–202.Google ScholarPubMed
Evans, S. J. W., Langdon, J. D., Rapidis, A. D., Johnson, N. W. (1982) Prognostic significance of STNMP and velocity of tumour growth in oral cancer. Cancer, 49: 773–776.3.0.CO;2-K>CrossRefGoogle ScholarPubMed
Farr, H. W., Arthur, K. (1972) Epidermoid carcinoma of the mouth and pharynx 1960–1964. Journal of Laryngology and Otology, 86: 243–252.CrossRefGoogle ScholarPubMed
Henk, M., Langdon, M. (1985) Malignant tumours of the oral cavity. Edward Arnold: London.Google Scholar
Hibbert, J., Marks, N. J., Winter, P. J., Shaheen, O. H. (1983) Prognostic factors in oral carcinoma and their relation to clinical staging. Clinical Otolaryngology, 8: 197–203.CrossRefGoogle ScholarPubMed
Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., Mantel, N., McPherson, K., Peto, J., Smith, P. G. (1976) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. British Journal of Cancer, 34: 585–612 and 35: 1–34.CrossRefGoogle ScholarPubMed
Shah, J. P., Cendon, R. A., Farr, H. W., Strong, E. W. (1976) Carcinoma of the oral cavity. American Journal of Surgery, 132: 504–507.CrossRefGoogle ScholarPubMed
Smith, C. J. (1973) Global epidemiology and aetiology of oral cancer. International Dental Journal, 32: 1, 82–93.Google Scholar
Tytor, M., Olofsson, J., Ledin, T., Brunks, U., Klintenberg, C. (1990) Squamous cell carcinoma of the oral cavity. A review of 176 cases with application of malignancy grading and DNA measurements. Clinical Otolaryngology, 15: 235–251.CrossRefGoogle ScholarPubMed
UICC (1987) TNM Classification of malignant tumours. (Hermanek, P. and Sobin, L. H., eds.) Springer Verlag: Berlin.CrossRefGoogle Scholar