Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-02T20:01:05.910Z Has data issue: false hasContentIssue false
  • English
  • Français

Profile of laryngological abnormalities in patients with amyotrophic lateral sclerosis

Published online by Cambridge University Press:  26 February 2007

J Tomik ,
B Tomik ,
D Partyka ,
J Skladzien  and
A Szczudlik
J Tomik*
Affiliation:
Department of Laryngology, Medical College, Jagiellonian University, Krakow, Poland
B Tomik
Affiliation:
Department of Neurology, Medical College, Jagiellonian University, Krakow, Poland.
D Partyka
Affiliation:
Department of Neurology, Medical College, Jagiellonian University, Krakow, Poland.
J Skladzien
Affiliation:
Department of Laryngology, Medical College, Jagiellonian University, Krakow, Poland
A Szczudlik
Affiliation:
Department of Neurology, Medical College, Jagiellonian University, Krakow, Poland.
*
Address for correspondence: Dr Jerzy Tomik, Department of Laryngology, Medical College, Jagiellonian University, 2 Sniadeckich St, 31-501 Krakow, Poland. Fax: +48 12 424 79 00 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Few studies have described laryngological evaluation of patients with amyotrophic lateral sclerosis. We assessed the laryngological abnormalities of 35 such patients (24 bulbar onset and 11 limb onset). In nine limb onset patients, we discovered signs of early vagal nerve dysfunction, prior to any clinical presentation of bulbar failure. However, in all bulbar onset patients studied, we noticed changes in the uni/bilateral position of the vocal folds and in the voice quality.

Keywords

Amyotrophic Lateral SclerosisLarynxVocal Cords
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 121 , Issue 11 , November 2007 , pp. 1064 - 1069
Copyright
Copyright © JLO (1984) Limited 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Leigh, PN, Abrahams, S, Al-Chalabi, A, Ampong, MA, Goldstein, LH, Johnson, J et al. The management of motor neurone disease. J Neurol Neurosurg Psychiatry 2003;74(suppl 4):32–47CrossRefGoogle ScholarPubMed
2Rosen, DR, Siddique, T, Patterson, D, Figlewicz, DA, Sapp, P, Hentati, A et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993;362:59–62CrossRefGoogle ScholarPubMed
3Strong, MJ. The basic aspects of therapeutics in amyotrophic lateral sclerosis. Pharmacol Ther 2003;98:379–414CrossRefGoogle ScholarPubMed
4Brooks, BR. El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial “Clinical limits of amyotrophic lateral sclerosis” workshop contributors. J Neurol Sci 1994;124(suppl):96–107CrossRefGoogle Scholar
5Kalra, S, Arnold, D. Neuroimaging in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2003;4:243–8CrossRefGoogle ScholarPubMed
6Hillel, AD, Miller, R. Bulbar amyotrophic lateral sclerosis: patterns of progression and clinical management. Head Neck 1989;11:51–9CrossRefGoogle ScholarPubMed
7Mitsumoto, H. Diagnosis and progression of ALS. Neurology 1997;48(suppl 4):2–8CrossRefGoogle Scholar
8Strand, EA, Miller, RM, Yorkston, KM, Hillel, AD. Management of oral-pharyngeal dysphagia symptoms in amyotrophic lateral sclerosis. Dysphagia 1996;11:129–39CrossRefGoogle ScholarPubMed
9Hillel, A, Dray, T, Miller, R, Yorkston, K, Konikow, N, Strande, E et al. Presentation of ALS to the otolaryngologist/head and neck surgeon: getting to the neurologist. Neurology 1999;53(suppl 5):22–5Google Scholar
10Watts, CR, Vanryckeghem, M. Laryngeal dysfunction in amyotrophic lateral sclerosis: a review and case report. BMC Ear, Nose, and Throat Disorders 2001;1:1–11CrossRefGoogle ScholarPubMed
11Janzen, VD, Rae, RE, Hudson, AJ. Otolaryngologic manifestations of amyotrophic lateral sclerosis. J Otolaryngol 1988;17:41–2Google ScholarPubMed
12Roth, CR, Glaze, LE, Goding, GS Jr, David, WS. Spasmodic dysphonia symptoms as initial presentation of amyotrophic lateral sclerosis. J Voice 1996;10:362–7CrossRefGoogle ScholarPubMed
13Isozaki, E, Hayashi, M, Hayashida, T, Oda, M, Hirai, S. Myopathology of the intrinsic laryngeal muscles in neurodegenerative diseases, with reference to the mechanism of vocal cord paralysis [in Japanese]. Rinsho Shinkeigaku 1998;38:711–18Google Scholar
14Chen, A, Garrett, CG. Otolaryngologic presentations of amyotrophic lateralsclerosis. Otolaryngol Head Neck Surg 2005;132:500–4CrossRefGoogle ScholarPubMed
15Tomik, B, Krupinski, J, Glodzik-Sobanska, L, Bala-Slodowska, M, Wszolek, W, Kusiak, M et al. Acoustic analysis of dysarthria profile in ALS patients. J Neurol Sci 1999;169:35–42CrossRefGoogle ScholarPubMed
16Aggarwal, A, Nicholson, G. Detection of preclinical motor neurone loss in SOD1 mutation carriers using motor unit number estimation. J Neurol Neurosurg Psychiatry 2002;73:199–201CrossRefGoogle ScholarPubMed
17Przedborski, S. Programmed cell death in amyotrophic lateral sclerosis: a mechanism of pathogenic and therapeutic importance. Neurologist 2004;10:1–7CrossRefGoogle ScholarPubMed
18Robbins, J, Scanlan, K, Brooks, BR. Recumbent apnea in amyotrophic lateral sclerosis (ALS) caused by mesopharyngeal closure due to epiglottic obstruction. Neurology 1998;38(suppl 1):425Google Scholar
19Polkey, MI, Lyall, RA, Green, M, Leigh, PN, Moxham, J. Expiratory muscle function in amyotrophic lateral sclerosis. Am J Respir Crit Care Med 1998;158:734–41CrossRefGoogle ScholarPubMed
20Klasner, E, Yorkston, K, Strand, E. Patterns of perceptual features in speakers with ALS: a preliminary study of prominence and intelligibility considerations. Journal of Medical Speech – Language Pathology 1999;7:117–25Google Scholar
21Aronson, AE, Ramig, LO, Winholtz, WS, Silber, SR. Rapid voice tremor, or “flutter”, in amyotrophic lateral sclerosis. Ann Otol Rhinol Laryngol 1992;101:511–18CrossRefGoogle Scholar