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The potential role of imaging techniques in avoiding neck dissection during salvage surgery after head and neck carcinoma treated with bioradiotherapy

Published online by Cambridge University Press:  06 September 2021

A Rovira ,
J Tornero ,
M Taberna ,
M Oliva ,
R Montal ,
J Nogues ,
A Mari ,
J M Viñals ,
A Lozano  and
M Maños
...Show all authors
A Rovira*
Affiliation:
Department of Otorhinolaryngology, Bellvitge University Hospital, Spain Faculty of Medicine, Catalan Institute of Oncology, Barcelona, Spain
J Tornero
Affiliation:
Department of Otorhinolaryngology, Bellvitge University Hospital, Spain
M Taberna
Affiliation:
Faculty of Medicine, Catalan Institute of Oncology, Barcelona, Spain Department of Medical Oncology, Catalan Institute of Oncology, Barcelona, Spain
M Oliva
Affiliation:
Department of Medical Oncology, Catalan Institute of Oncology, Barcelona, Spain
R Montal
Affiliation:
Department of Medical Oncology, Catalan Institute of Oncology, Barcelona, Spain
J Nogues
Affiliation:
Department of Otorhinolaryngology, Bellvitge University Hospital, Spain
A Mari
Affiliation:
Department of Maxillofacial Surgery, Bellvitge University Hospital, Spain
J M Viñals
Affiliation:
Department of Plastic and Reconstructive Surgery, Bellvitge University Hospital, Spain
A Lozano
Affiliation:
Department of Radiotherapy, Hospital Duran I Reynalds, Catalan Institute of Oncology, Barcelona,University of Barcelona, Spain
M Maños
Affiliation:
Department of Otorhinolaryngology, Bellvitge University Hospital, Spain Faculty of Medicine, Catalan Institute of Oncology, Barcelona, Spain
R Mesia
Affiliation:
Faculty of Medicine, Catalan Institute of Oncology, Barcelona, Spain Department of Medical Oncology, Catalan Institute of Oncology, Barcelona, Spain
*
Author for correspondence: Mr Aleix Rovira, ENT Department, Guy's Hospital, Great Maze Pond, LondonSE1 9RT, UK E-mail: [email protected]
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Abstract

Objective

This study aimed to evaluate the effectiveness of computed tomography and positron emission tomography-computed tomography prior to salvage surgery after head and neck carcinoma treated with bioradiotherapy and to look at the role of neck dissection in this setting.

Method

This study was a retrospective chart review of a series of consecutive patients with locally advanced head and neck squamous cell carcinoma treated with bioradiotherapy. Radiological and pathological stages were compared to evaluate the accuracy of computed tomography and positron emission tomography-computed tomography in detecting occult neck metastasis in the context of recurrence of primary tumour. In order to assess the impact of neck dissection on survival, Kaplan–Meier survival curves after salvage surgery with and without neck dissection were derived.

Results

A total of 268 patients were identified, of which 22 underwent salvage surgery. The negative predictive value of computed tomography and positron emission tomography-computed tomography was excellent. Neck dissection did not represent an improvement on overall, disease specific and regional recurrence free survival (p = 0.67, p = 0.91 and p = 0.62, respectively) amongst clinically and radiologically negative necks.

Conclusion

Conservative treatment of the neck should be considered when dealing with patients with primary site recurrence or persistent disease after bioradiotherapy without evidence of neck disease.

Keywords

CetuximabSquamous Cell Carcinoma Of Head And NeckNeck DissectionPositron Emission Tomography Computed TomographySalvage Therapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 135 , Issue 11 , November 2021 , pp. 970 - 975
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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Footnotes

Mr A Rovira takes responsibility for the integrity of the content of the paper

References

Woolgar, JA, Triantafyllou, A, Lewis, JS, Hunt, J, Williams, MD, Takes, RP et al. Prognostic biological features in neck dissection specimens. Eur Arch Otorhinolaryngol 2013;270:1581–9210.1007/s00405-012-2170-9CrossRefGoogle ScholarPubMed
Shah, JP, Gil, Z. Current concepts in management of oral cancer – surgery. Oral Oncol 2009;45:394–40110.1016/j.oraloncology.2008.05.017CrossRefGoogle ScholarPubMed
Grégoire, V, Lefebvre, JL, Licitra, L, Felip, E, EHNS-ESMO-ESTRO Guidelines Working Group. Squamous cell carcinoma of the head and neck: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010;21(suppl 5):184–610.1093/annonc/mdq185CrossRefGoogle ScholarPubMed
Pfister, DG, Laurie, SA, Weinstein, GS, Mendenhal, WM, Adelstein, DJ, Ang, KK et al. American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol 2006;24:3693–70410.1200/JCO.2006.07.4559CrossRefGoogle Scholar
Pfister, DG, Spencer, S, Brizel, DM, Burtness, B, Busse, PM, Caudell, JJ et al. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) head and neck cancer. Version 1.2015. In: http://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf [21 March 2020]Google Scholar
Sato, JD, Kawamoto, T, Le, AD, Mendelsohn, J, Polikoff, J, Sato, GH. Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Mol Biol Med 1983;1:511–29Google ScholarPubMed
Kurai, J, Chikumi, H, Hashimoto, K, Yamaguchi, K, Yamasaki, A, Sako, T et al. Antibody-dependent cellular cytotoxicity mediated by cetuximab against lung cancer cell lines. Clin Cancer Res 2007;13:1552–6110.1158/1078-0432.CCR-06-1726CrossRefGoogle ScholarPubMed
Bonner, J, Harari, P, Giralt, J, Azarnia, N, Shin, DM, Cohen, RB et al. Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck. New Engl J Med 2006;354:56710.1056/NEJMoa053422CrossRefGoogle ScholarPubMed
Vermorken, JB, Mesia, R, Rivera, F, Remenar, E, Kawecki, A, Rorrey, S et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 2008;359:1116–2710.1056/NEJMoa0802656CrossRefGoogle ScholarPubMed
Vermorken, JB, Trigo, J, Hitt, R, Koralewski, P, Diaz-Rubio, E, Rolland, F et al. Open-label, uncontrolled, multicentre phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. J Clin Oncol 2007;25:2171–710.1200/JCO.2006.06.7447CrossRefGoogle ScholarPubMed
Rovira, A, Tornero, J, Oliva, M, Taberna, M, Montal, R, Nogues, J et al. Salvage surgery after head and neck squamous cell carcinoma treated with bioradiotherapy. Head Neck 2017;39:116–2110.1002/hed.24549CrossRefGoogle ScholarPubMed
Edge, SB, Byrd, DR, Compton, C, Fritz, AG, Greene, FL, Trotti A, III, eds. AJCC Cancer Staging Manual, 7th edn. New York: Springer, 2010Google ScholarPubMed
Hitt, R, López-Pousa, A, Martínez-Trufero, J. Phase III study comparing cisplatin plus fluorouracil to paclitaxel, cisplatin, and fluorouracil induction chemotherapy followed by chemoradiotherapy in locally advanced head and neck cancer. J Clin Oncol 2005;23:8636–4510.1200/JCO.2004.00.1990CrossRefGoogle ScholarPubMed
Lindberg, R. Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer 1972;29:1446–910.1002/1097-0142(197206)29:6<1446::AID-CNCR2820290604>3.0.CO;2-C3.0.CO;2-C>CrossRefGoogle ScholarPubMed
Byers, R. Modified neck dissection: a study of 967 cases from 1970 to 1980. Am J Surg 1985;150:414–2110.1016/0002-9610(85)90146-1CrossRefGoogle ScholarPubMed
Shah, J, Candela, F, Poddar, A. The patterns of cervical lymph node metastases from squamous carcinoma of the oral cavity. Cancer 1990;66:109–1310.1002/1097-0142(19900701)66:1<109::AID-CNCR2820660120>3.0.CO;2-A3.0.CO;2-A>CrossRefGoogle ScholarPubMed
Taberna, M, Rullan, AJ, Hierro, C, Navarro, V, Vazquez, S, Lozano, A et al. Late toxicity after radical treatment for locally advanced head and neck cancer. Oral Oncol 2015;51:795–910.1016/j.oraloncology.2015.05.002CrossRefGoogle ScholarPubMed
Basheeth, N, O'Leary, G, Sheahan, P. Pharyngocutaneous fistula after salvage laryngectomy: impact of interval between radiotherapy and surgery, and performance of bilateral neck dissection. Head Neck 2014;36:580–410.1002/hed.23337CrossRefGoogle ScholarPubMed
Pezier, TF, Nixon, IJ, Scotton, W, Joshi, A, Guerrero-Urbano, T, Oakley, R et al. Should elective neck dissection be routinely performed in patients undergoing salvage total laryngectomy? J Laryngol Otol 2014;128:279–8310.1017/S0022215114000425CrossRefGoogle ScholarPubMed
van den Brekel, MW, Stel, HV, van der Valk, P, van der Waal, I, Meyer, CJ, Snow, GB. Micrometastases from squamous cell carcinoma in neck dissection specimens. Eur Arch Otorhinolaryngol 1992;249:349–5310.1007/BF00179388CrossRefGoogle ScholarPubMed
Perie, S, Hugentobler, A, Susini, B, Balogova, S, Grahek, D, Kerrou, K et al. Impact of FDG-PET to detect recurrence of head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg 2007;137:647–53Google ScholarPubMed
Brouwer, J, Hooft, L, Hoekstra, OS, Riphagen, II, Castelijns, JA, de Bree, R et al. Systematic review: accuracy of imaging tests in the diagnosis of recurrent laryngeal carcinoma after radiotherapy. Head Neck 2008;30:889–9710.1002/hed.20790CrossRefGoogle Scholar
Montal, R, Oliva, M, Taberna, M, De Avila, L, Rovira, A, Cos, M et al. Residual neck disease management in squamous-cell carcinoma of the head and neck treated with radiotherapy plus cetuximab. Clin Transl Oncol 2016;18:1140–610.1007/s12094-016-1496-yCrossRefGoogle Scholar
Birkeland, AC, Rosko, AJ, Issa, MR, Shuman, AG, Prince, ME, Wolf, GT et al. Occult nodal disease prevalence and distribution in recurrent laryngeal cancer requiring salvage laryngectomy. Otolaryngol Head Neck Surg 2016;154:473–910.1177/0194599815627811CrossRefGoogle ScholarPubMed
Freiser, ME, Ojo, RB, Lo, K, Saint-Victor, S, Bollig, C, Nayak, CS, Sargi, ZB. Complications and oncologic outcomes following elective neck dissection with salvage laryngectomy for the N0 neck. Am J Otolaryngol 2016;37:186–9410.1016/j.amjoto.2016.01.004CrossRefGoogle ScholarPubMed
Bohannon, IA, Desmond, RA, Clemons, L, Magnuson, JS, Carroll, WR, Rosenthal, EL. Management of the N0 neck in recurrent laryngeal squamous cell carcinoma. Laryngoscope 2010;120:58–61Google ScholarPubMed
Temam, S, Koka, V, Mamelle, G, Julieron, M, Carmantrant, R, Marandas, P et al. Treatment of the N0 neck during salvage surgery after radiotherapy of head and neck squamous cell carcinoma. Head Neck 2005;27:653–810.1002/hed.20234CrossRefGoogle ScholarPubMed
Sanabria, A, Silver, CE, Olsen, KD. Is elective neck dissection indicated during salvage surgery for head and neck squamous cell carcinoma? Eur Arch Otorhinolaryngol 2014;271:3111–910.1007/s00405-014-2893-xCrossRefGoogle ScholarPubMed