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Post-radiation primary intranodal leiomyosarcoma

Published online by Cambridge University Press:  29 June 2007

Hiroaki Fujii ,
Leon Barnes ,
Jonas T. Johnson  and
Silloo B. Kapadia
Hiroaki Fujii
Affiliation:
Departments of Pathology, Presbyterian University Hospital, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582.
Leon Barnes
Affiliation:
Departments of Pathology, Presbyterian University Hospital, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582.
Jonas T. Johnson
Affiliation:
Departments of Otolaryngology, The Eye and Ear Institute, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582.
Silloo B. Kapadia*
Affiliation:
Departments of Pathology, Presbyterian University Hospital, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582.
*
Address for correspondence: Silloo B. Kapadia, M.D., Department of Pathology, Presbyterian University Hospital, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA.
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Abstract

An unusual case of post-radiation primary intranodal leiomyosarcoma of the cervical lymph node is presented. The patient was a 32-year-old white man who was treated in 1986 with hemiglossectomy and right neck dissection, followed by radiation therapy, for squamous cell carcinoma of the tongue. Six years later, he presented with an enlarged left cervical lymph node which on biopsy showed a high grade spindle cell malignant neoplasm. Immunohistochemistry and electron microscopic study verified the smooth muscle origin of the tumour.

Extensive work-up for a second primary lesion was negative. Primary intranodal leiomyosarcoma is extremely rare. We briefly discuss the histological differential diagnosis of spindle cell lesions of lymph nodes, leiomyosarcoma of the vessel wall and radiation-associated sarcoma.

Keywords

LeiomyosarcomaLymph nodesNeckRadiotherapy, complicationsCarcinoma, squamous cellTongue
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 1 , January 1995 , pp. 80 - 83
Copyright
Copyright © JLO (1984) Limited 1995

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Footnotes

Supported by the Pathology Education and Research Foundation, Department of Pathology, University of Pittsburgh School of Medicine.

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