Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-28T02:03:35.514Z Has data issue: false hasContentIssue false
  • English
  • Français

Post-irradiation sudden deafness

Published online by Cambridge University Press:  29 June 2007

Yi-Ho Young  and
Pei-Jen Lou
Yi-Ho Young*
Affiliation:
Department of Otolaryngology, National Taiwan University, Taipei, Taiwan.
Pei-Jen Lou
Affiliation:
Department of Otolaryngology, National Taiwan University, Taipei, Taiwan.
*
Address for correspondence: Yi-Ho Young, M.D., Department of Otolaryngology, National Taiwan University Hospital, 1 Chang-te St., Taipei, Taiwan. Fax: (886)-2-23410905 e-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

As in radiation-induced cancer, post-irradiation sudden deafness (PISD) is defined as sudden onset deafness in patients post-irradiation. Fifteen nasopharyngeal carcinoma (NPC) patients with PISD were enrolled in this study. The mean interval from the completion of irradiation to the occurrence of PISD was 12 years. Seven had total deafness, seven had profound hearing loss, and one had moderate hearing loss. Nine out of 15 (60 per cent) patients experienced hearing recovery within three months after treatment. In conclusion, PISD is a late complication in NPC patients post-irradiation. The causative mechanism is theorized as vascular insufficiency.

Keywords

Deafness, suddenNasopharyngeal neoplasmsRadiation effects
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 9 , September 1999 , pp. 815 - 817
Copyright
Copyright © JLO (1984) Limited 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Gamble, J. E., Peterson, E. A., Chandler, J. R. (1968) Radiation effects on the inner ear. Archives of Otolaryngology 88: 156–161.CrossRefGoogle ScholarPubMed
Guida, R. A., Finn, D. G., Buchalter, I. H., Brookler, K. H., Kimmelmamn, C. P. (1990) Radiation injury to temporal bone. American Journal of Otology 11: 6–11.Google ScholarPubMed
Huang, S. C., Lui, L. T., Lynn, T. C. (1985) Nasopharyngeal carcinoma: Study III. A review of 1206 patients treated with combined modalities. International Journal of Radiation Oncology Biology Physics 11: 1789–1793.CrossRefGoogle Scholar
Hsu, M. M., Young, Y.-H., Lin, K. L. (1995) Eustachian tube function of patients with nasopharyngeal carcinoma. Annals of Otology Rhinology and Laryngology 104: 453–455.CrossRefGoogle ScholarPubMed
Nomura, Y. (1988) Diagnostic criteria for sudden deafness, mumps deafness and perilymphatic fistula. Acta Otolaryngologica 108 (Suppl 456): 7–8.CrossRefGoogle Scholar
Redleaf, M. I., Bauer, C. A., Gantz, B. J., Hoffman, H. T., McCabe, B. F. (1995) Diatrizoate and dextran treatment of sudden sensorineural hearing loss. American Journal of Otology 16: 295–303.Google ScholarPubMed
Steeves, R. A., Bataini, J. P. (1981) Neoplasms induced by megavoltage radiation in the head and neck region. Cancer 47: 1770–1774.3.0.CO;2-7>CrossRefGoogle ScholarPubMed
Wilkins, S. A., Mattox, D. E., Lyles, A. (1987) Evaluation of a ‘shotgun’ regimen for sudden hearing loss. Otolaryngology – Head and Neck Surgery 97: 474–480.CrossRefGoogle ScholarPubMed
Young, Y.-H., Hsieh, T. (1992) Eustachian tube dysfunction in patients with nasopharyngeal carcinoma, pre- and postirradiation. European Archives of Otorhinolaryngology 289: 206–208.Google Scholar
Young, Y.-H., Lin, K. L., Ko, J. Y. (1995) Otitis media with effusion in patients with nasopharyngeal carcinomapostirradiation. Archives of Otolaryngology – Head and Neck Surgery 121: 765–768.CrossRefGoogle Scholar
Young, Y.-H., Cheng, P.-W., Ko, J. Y. (1997) A 10-year longitudinal study of tubal function in patients with nasopharyngeal carcinoma after irradiation. Archives of Otolaryngology – Head and Neck Surgery 123: 945–948.CrossRefGoogle ScholarPubMed
Young, Y.-H., Sheen, T.-S. (1998) Preservation of tubal function in patients of nasopharyngeal carcinoma, postirradiation. Acta Otolaryngologica 118: 280–283.Google ScholarPubMed