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Phenylthiocarbamide taste perception and susceptibility to motion sickness: linking higher susceptibility with higher phenylthiocarbamide taste acuity

Published online by Cambridge University Press:  05 February 2008

K Sharma ,
P Sharma ,
A Sharma  and
G Singh
K Sharma*
Affiliation:
Department of Anthropology, Panjab University, Chandigarh, India
P Sharma
Affiliation:
Department of Anthropology, Panjab University, Chandigarh, India
A Sharma
Affiliation:
Department of Anthropology, Panjab University, Chandigarh, India
G Singh
Affiliation:
Department of Anthropology, Panjab University, Chandigarh, India
*
Address for correspondence: Dr Krishan Sharma, Professor of Anthropalogy, Panjab University, Chandigarh 160014, India. E-mail: [email protected]
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Abstract

Objective:

This study is the first attempt to link quantified phenylthiocarbamide bitter taste recognition threshold with susceptibility to motion sickness.

Subjects:

The study was conducted on a sample of 291 teenage Rajput children (146 males and 145 females; age range 13–19 years) from the Sirmour district of Himachal Pradesh, India. Phenylthiocarbamide taste sensitivity was measured by administering a serial dilution of a freshly prepared phenylthiocarbamide solution, following the method of Harris and Kalmus. Motion sickness susceptibility was assessed retrospectively via interview.

Results:

About 40 per cent of the subjects had experienced motion sickness in the past. The mean and standard deviation of phenylthiocarbamide taste thresholds in non-tasters and tasters were 0.83 ± 0.87 and 7.98 ± 1.86, respectively. A bimodal distribution test (D/S) index of 5.24 confirmed bimodality of phenylthiocarbamide taste threshold distribution. The Mann–Whitney U test rejected the null hypothesis of μ1 = μ2 and thus confirmed the existence of differences in the distributions of phenylthiocarbamide taste threshold between individuals susceptible and not susceptible to motion sickness. Individuals susceptible to motion sickness had lower mean and median taste thresholds, indicating higher phenylthiocarbamide taste sensitivity, compared with non-susceptible individuals. The frequency of non-tasters was about 10 per cent in both motion sickness susceptible and non-susceptible individuals. The simple division of phenylthiocarbamide tasting ability into tasters and non-tasters was a less sensitive criterion with which to measure the association of this ability with motion sickness susceptibility. However, further differentiation of tasters into weak threshold, medium threshold and super threshold (‘supersensitive’) tasters clearly revealed a highly significantly increased risk of motion sickness in super threshold tasters (i.e. threshold solution number ≥12). The ratio of motion sickness susceptible individuals to non-susceptible individuals was 1:1.7 for non-tasters (threshold solution numbers zero to three) and weak and medium tasters (threshold solution numbers four to 11), but the trend was reversed for super threshold tasters (threshold solution numbers 12 and 13), in whom the ratio was 2:1.

Conclusion:

Individuals exhibiting greater phenylthiocarbamide taste acuity (i.e. supersensitive tasters) had a higher susceptibility to motion sickness than did non-, weak and medium phenylthiocarbamide tasters, as measured in terms of their taste thresholds (i.e. threshold solution numbers zero to 11).

Keywords

PhenylthioureaPhenylthiocarbamideTasteMotion Sickness
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 10 , October 2008 , pp. 1064 - 1073
Copyright
Copyright © JLO (1984) Limited 2008

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References

1 Fox, AL. Six in ten ‘tasteblind’ to bitter chemical. Sci Newslett 1931;9:249Google Scholar
2 Blakeslee, AF. Genetics of sensory thresholds: taste for phenyl thiocarbamide. Proc Nat Acad Sci 1932;18:120–30CrossRefGoogle Scholar
3 Harris, H, Kalmus, H. The measurement of taste sensitivity to phenylthiourea (PTC). Ann Eugen 1949;15:24–31CrossRefGoogle Scholar
4 Barnicot, NA, Harris, H, Kalmus, H. Taste thresholds of further eighteen compounds and their correlation with PTC thresholds. Ann Eugen 1951;16:119–28CrossRefGoogle ScholarPubMed
5 Kalmus, H. Improvements in the classification of the taster genotypes. Ann Hum Genet 1958;22:222–30CrossRefGoogle ScholarPubMed
6 Reed, DR, Bartoshuk, LM, Duffy, V, Marino, S, Price, RA. Propylthiouracil tasting: determination of underlying threshold distributions using maximum likelihood method. Chem Senses 1995;20:529–33CrossRefGoogle Scholar
7 Reed, DR, Namthakumar, E, North, M, Bell, C, Bartishuk, LM, Price, RA. Localization of a gene for bitter taste perception to human chromosome 5p 15. Am J Hum Genet 1999;64:1478–80CrossRefGoogle Scholar
8 Kim, UK, Jorgenson, E, Coon, H, Leppert, M, Risch, N, Drayna, D. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 2003;299:1221–5CrossRefGoogle ScholarPubMed
9 Drayana, D, Coon, H, Kim, UK, Elsner, T, Cromer, K, Otterud, B et al. Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p. Hum Genet 2003;112:562–72Google Scholar
10 Pal, SK, Sharma, K, Pathak, A, Sawhney, IMS, Prabhakar, S. Possible relationship between phenylthiocarbamide taste sensitivity and epilepsy. Neurology India 2004;52:206–9Google ScholarPubMed
11 Sharma, K. Genetic epidemiology of epilepsy: a twin study. Neurology India 2005;53:93–8CrossRefGoogle ScholarPubMed
12 Moberg, PJ, Roalf, DR, Balderston, CC, Kanes, SJ, Gur, RE, Turetsky, BI. Phenylthiocarbamide perception in patients with schizophrenia and first-degree family members. Am J Psychiatry 2005;162:788–90CrossRefGoogle ScholarPubMed
13 Facchini, F, Abbati, A, Campagnoni, S. Possible relations between sensitivity to phenylthiocarbamide and goiter. Hum Biol 1990;62:545–52Google ScholarPubMed
14 Ahuja, YR, Reddy, OS, Reddy, SS. PTC taste sensitivity among women with carcinoma of the cervix. Anthropologist 1977;24:40–2Google Scholar
15 MacKenzie, CG, MacKenzie, JB. Effects of sulfonamides and thioureas on the thyroid gland and basal metabolism. Endocrinology 1943;32:185–205CrossRefGoogle Scholar
16 Fischer, R, Griffin, F, Kaplan, AR. Taste thresholds, cigarette smoking and food dislikes. Med Exp 1963;9:151–67Google ScholarPubMed
17 Pelchat, ML, Danowski, S. A possible genetic association between PROP-tasting and alcoholism. Phys Behav 1992;51:1261–6CrossRefGoogle ScholarPubMed
18 Bartoshuk, LM, Conner, E, Grubin, D, Karrer, TA, Kochenbach, K, Palcso, M et al. PROP supertasters and the perception of ethyl alcohol. Chem Senses 1993;18:526–7Google Scholar
19 Di Carlo, ST, Powers, AS. Propylthiouracil tasting as a possible genetic association for two types of alcoholism. Physiol Behav 1998;64:147–52Google ScholarPubMed
20 Reason, JT, Brand, JJ. Motion sickness. New York: Academic Press, 1975Google Scholar
21 Yardley, L. Motion sickness and perception: a reappraisal of the sensory conflict approach. Br J Psychol 1992;83:449–71CrossRefGoogle ScholarPubMed
22 Sharma, K, Aparna, . Prevalence and correlates of susceptibility to motion sickness. Acta Genet Med Gemellol 1997;46:105–21Google ScholarPubMed
23 Sharma, K. Susceptibility to motion sickness. Acta Genet Med Gemellol 1980;29:157–62Google ScholarPubMed
24 Hall, MJ, Bartoshuk, LM, Caine, WS, Stevens, JC. PTC taste blindness and the taste of caffeine. Nature 1975;253:442–3CrossRefGoogle ScholarPubMed
25 Bartoshuk, LM. Bitter taste of saccharine: related to the genetic ability to taste the bitter substance 6-n-propyl-tiouracil (PROP). Science 1979;205:934–5CrossRefGoogle Scholar
26 Penrose, LS. Measurement of pleiotropic effect in PTC. Ann Eugen 1951;16:134–41CrossRefGoogle Scholar
27 Zar, JH. Biostatistical Analysis. Upper Saddle River: Prentice-Hall, 1999Google Scholar
28 Bartoshuk, LM. The psychophysics of taste. Am J Clin Nutr 1978;31:1068–77CrossRefGoogle ScholarPubMed
29 Bartoshuk, L, Duffy, V, Miller, I. PTC/PROP tasting: anatomy, psychophysics and sex effects. Physiol Behav 1994;56:1165–71CrossRefGoogle ScholarPubMed
30 Bartoshuk, LM. Comparing sensory experience across individuals: recent psychophysical advances illuminate genetic variation in taste perception. Chem Senses 2000;25:447–60CrossRefGoogle ScholarPubMed
31 Prodi, DA, Drayna, D, Forabosco, P, Palmas, MA, Maestrale, GB, Piras, D et al. Bitter taste in a Sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R 38 bitter receptor gene. Chem Senses 2004;29:697–702CrossRefGoogle Scholar
32 McBurney, DH. Effects of adaptation on human taste function. In: Pfaffmann, C, ed. Olfaction and Taste III. New York: Pergamon Press, 1969;407–19Google Scholar
33 Money, KE. Motion sickness. Physiol Rev 1970;50:1–59CrossRefGoogle ScholarPubMed
34 Aggarwal, S, Sachdeva, MP. A study of taste sensitivity of phenyl thiocarbamide (PTC) and colour blindness among the Rajputs of Kasauli, Himachal Pradesh. Anthropologist 2004;6:289–90CrossRefGoogle Scholar
35 Lugg, JWG. Taste thresholds for phenylthiocarbamide in some population groups. iii. The threshold of some groups living in Japan. Ann Hum Genet 1966;29:217–30CrossRefGoogle Scholar
36 Guo, SW, Shen, FM, Wang, YD, Zheng, CJ. Threshold distribution of phenylthiocarbamide (PTC) in the Chinese population. Ann N Y Acad Sci 1998;855:810–12CrossRefGoogle ScholarPubMed
37 Tiwari, SC. Taste thresholds for phenylthiourea among Tibetans. Anthropologist 1966;13:51–64Google Scholar
38 Sharma, JC. Taste sensitivity to PTC among three mongoloid populations of the Indian border. Acta Genet Med Gemellol 1967;16:317–24CrossRefGoogle Scholar
39 Bhalla, V, Chopra, SRK. Gene differentiation in hill Rajput (Kanets) of upper Sutlej valley (H.P.). Ind J Phys Anthropol Hum genet 1979;5:1–6Google Scholar
40 Lindemann, B. Taste perception. Physiol Rev 1996;76:718–66CrossRefGoogle Scholar
41 Chandrashekar, J, Mueller, KL, Hoon, MA, Adler, E, Feng, L, Guo, W et al. T2Rs function as bitter taste receptors. Cell 2000;100:703–11CrossRefGoogle ScholarPubMed
42 Matsunami, H, Montmayeur, JP, Buck, LB. A family of candidate taste receptors in human and mouse. Nature 2000;404:601–4CrossRefGoogle ScholarPubMed
43 Shi, P, Zhang, J, Yang, H, Zhang, YP. Adaptive diversification of bitter taste receptor genes in mammalian evolution. Mol Biol Evol 2003;20:805–14CrossRefGoogle ScholarPubMed
44 Bartoshuk, LM, Duffy, VB, Reed, D, Williams, A. Supertasting, earaches and head injury: genetics and pathology alter our taste worlds. Neurosci Biobehav Rev 1996;20:79–87CrossRefGoogle ScholarPubMed
45 Cowart, BJ, Yokomukai, Y, Beauchamp, GK. Bitter taste in aging: compound-specific decline in sensitivity. Physiol Behav 1994;56:1237–41CrossRefGoogle ScholarPubMed
46 Mennella, JA, Pepino, MY, Reed, DR. Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics 2005;115:216–22CrossRefGoogle ScholarPubMed