Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-24T07:36:43.807Z Has data issue: false hasContentIssue false

Peritonsillar infiltration of lidocaine with adrenaline is associated with increased risk of secondary post-tonsillectomy haemorrhage

Published online by Cambridge University Press:  09 October 2018

H K Tolska*
Affiliation:
Division of Anesthesiology, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Finland
A J Takala
Affiliation:
Division of Anesthesiology, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Finland
J Jero
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Turku University Hospital, Finland
*
Author for correspondence: Dr Hanna Kaisa Tolska, Division of Anesthesiology, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Kasarmikatu 11–13, PO Box 263, 00029 HUS, Finland E-mail: [email protected]

Abstract

Objectives

In order to evaluate the safety of tonsillectomy among children, we retrospectively studied the incidence of post-operative complications, adverse events and their association with peri-operative medication.

Methods

Data were collected from the medical records of 691 patients aged 1–16 years, including details of post-operative complications (any unplanned contact with the hospital), analgesics, dexamethasone, 5-HT3 antagonists, local anaesthetic and haemostatic agents.

Results

Recovery was complicated in 13.6 per cent of patients, of whom 8.4 per cent were re-admitted to the ward. The most common complication was post-tonsillectomy haemorrhage, experienced by 7.1 per cent of patients. Re-operation under general anaesthesia (for grade III post-tonsillectomy haemorrhage) was required by 4.2 per cent of patients. Peritonsillar infiltration of lidocaine with adrenaline increased the risk of post-tonsillectomy haemorrhage (odds ratio = 4.1; 95 per cent confidence interval = 2.1 to 8.3).

Conclusion

Every seventh paediatric patient experienced a complicated recovery after tonsillectomy, caused by post-tonsillectomy haemorrhage in most cases. Local peritonsillar infiltration of lidocaine with adrenaline was associated with an increased risk of post-tonsillectomy haemorrhage.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited, 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr H K Tolska takes responsibility for the integrity of the content of the paper

References

1Windfuhr, JP. Hemorrhage following pediatric tonsillectomy before puberty. Int J Pediatr Otorhinolaryngol 2001;58:197204Google Scholar
2Randall, D, Hoffer, M. Complications of tonsillectomy and adenoidectomy. Otolaryngol Head Neck Surg 1998;118:61–8Google Scholar
3MacCallum, PL, MacRae, DL, Sukerman, S, MacRae, E. Ambulatory adenotonsillectomy in children less than 5 years of age. J Otolaryngol 2001;30:75–8Google Scholar
4Kanerva, M, Tarkkila, P, Pitkäranta, A. Day-case tonsillectomy in children: parental attitudes and consultation rates. Int J Pediatr Otorhinolaryngol 2003;67:777–84Google Scholar
5Wei, JL, Beatty, CW, Gustafson, RO. Evaluation of posttonsillectomy hemorrhage and risk factors. Otolaryngol Head Neck Surg 2000;123:229–35Google Scholar
6Liu, JH, Anderson, KE, Willging, JP, Myer, CM 3rd, Shott, SR, Bratcher, GO et al. Posttonsillectomy haemorrhage: what is it and what should be recorded? Arch Otolaryngol Head Neck Surg 2001;127:1271–5Google Scholar
7Valtonen, H, Qvarnberg, Y, Blomgren, K. Patient contact with healthcare professionals after elective tonsillectomy. Acta Otolaryngol 2004;124:1086–9Google Scholar
8Drake-Lee, A, Stokes, M. A prospective study of the length of stay of 150 children following tonsillectomy and/or adenoidectomy. Clin Otolaryngol Allied Sci 1998;23:491–5Google Scholar
9Beaulieu, P. Non-opioid strategies for acute pain management. Can J Anaesth 2007;6:481–5Google Scholar
10Marret, E, Flahault, A, Samama, C-M, Bonnet, F. Effects of postoperative, nonsteroidal, anti-inflammatory drugs on bleeding risk after tonsillectomy. Anesthesiology 2003;98:1497–502Google Scholar
11Cardwell, M, Siviter, G, Smith, A. Non-steroidal anti-inflammatory drugs and perioperative bleeding in pediatric tonsillectomy. Cochrane Database Syst Rev 2005;(18):CD003591Google Scholar
12Hollis, LJ, Burton, MJ, Millar, JM. Perioperative local anesthesia for reducing pain following tonsillectomy. Cochrane Database Syst Rev 2000;(2):CD001874Google Scholar
13Grainger, J, Saravanappa, N. Local anaesthetic for post-tonsillectomy pain: a systematic review and meta-analysis. Clin Otolaryngol 2008;33:411–19Google Scholar
14Patel, RI, Hannallah, RS. Anesthetic complications following pediatric ambulatory surgery: a 3-yr study. Anesthesiology 1988;6:1009–12Google Scholar
15Rose, JB, Brenn, BR, Corddry, DH, Thomas, PC. Preoperative oral ondansetron for pediatric tonsillectomy. Anesth Analg 1996;82:558–62Google Scholar
16Gan, TJ, Meyer, TA, Apfel, CC, Chung, F, Davis, PJ, Habib, AS et al. Society for Ambulatory Anesthesia guidelines for the management of postoperative nausea and vomiting. Anesth Analg 2007;105:1615–28Google Scholar
17Holte, K, Kehlet, H. Perioperative single-dose glucocorticoid administration: pathophysiologic effects and clinical implications. J Am Coll Surg 2002;195:694712Google Scholar
18Afman, CE, Welge, JA, Steward, DL. Steroids for post-tonsillectomy pain reduction: meta-analysis of randomized controlled trials. Otolaryngol Head Neck Surg 2006;134:181–6Google Scholar
19Czarnetzki, C, Elia, N, Lysakowski, C, Dumont, L, Landis, BN, Giger, R et al. Dexamethasone and risk of nausea and vomiting and postoperative bleeding after tonsillectomy in children: a randomized trial. JAMA 2008;300:2621–30Google Scholar
20Anand, VT, Phillipps, JJ, Allen, D, Joynson, DH, Fielder, HM. A study of postoperative fever following paediatric tonsillectomy. Clin Otolaryngol Allied Sci 1999;24:360–4Google Scholar
21Windfuhr, J, Seehafer, M. Classification of haemorrhage following tonsillectomy. J Laryngol Otol 2001;115:457–61Google Scholar
22Ovesen, T, Kamarauskas, G, Dahl, M, Mainz, J. Pain and bleeding are the main determinants of unscheduled contacts after outpatient tonsillectomy. Dan Med J 2012;59:A4382Google Scholar
23Duval, M, Wilkes, J, Korgenski, K, Srivastava, R, Meier, J. Causes, costs, and risk factors for unplanned return visits after adenotonsillectomy in children. Int J Pediatr Otorhinolaryngol 2015;79:1640–6Google Scholar
24Blakley, BW. Post-tonsillectomy bleeding: how much is too much? Otolaryngol Head Neck Surg 2009;140:288–90Google Scholar
25Coordes, A, Soudry, J, Hofmann, VM, Lenarz, M. Gender-specific risk factors in post-tonsillectomy hemorrhage. Eur Arch Otorhinolaryngol 2016;273:4535–41Google Scholar
26Thorisdottir, H, Ratnoff, OD, Maniglia, AJ. Activation of Hageman factor (factor XII) by bismuth subgallate, a hemostatic agent. J Lab Clin Med 1998;112:481–6Google Scholar
27Callanan, V, Curran, AJ, Smyth, DA, Gormley, PK. The influence of bismuth subgallate and adrenaline paste upon operating time and operative blood loss in tonsillectomy. J Laryngol Otol 1995;109:206–8Google Scholar
28Hatton, RC. Bismuth subgallate-epinephrine paste in adenotonsillectomies. Ann Pharmacother 2000;34:522–5Google Scholar
29Papangelou, L. Hemostasis in tonsillectomy. A comparison of electrocoagulation and ligation. Arch Otolaryngol 1972;96:358–60Google Scholar
30Sivamani, RK, Pullar, CE, Manabat-Hidalgo, CG, Rocke, DM, Carlsen, RC, Greenhalgh, DG et al. Stress-mediated increases in systemic and local epinephrine impair skin wound healing: potential new indication for beta blockers. PLoS Med 2009;6:e12Google Scholar
31Peitzman, ER, Zaidman, NA, Maniak, PJ, O'Grady, SM. Agonist binding to β-adrenergic receptors on human airway epithelial cells inhibits migration and wound repair. Am J Physiol Cell Physiol 2015;309:C84755Google Scholar
32Dasu, MR, Ramirez, SR, La, TD, Gorouhi, F, Nguyen, C, Lin, BR et al. Crosstalk between adrenergic and toll-like receptors in human mesenchymal stem cells and keratinocytes: a recipe for impaired wound healing. Stem Cells Transl Med 2014;3:745–59Google Scholar
33Lucchinetti, E, Awad, AE, Rahman, M, Feng, J, Lou, PH, Zhang, L et al. Antiproliferative effects of local anesthetics on mesenchymal stem cells: potential implications for tumor spreading and wound healing. Anesthesiology 2012;116:841–56Google Scholar
34Rodrigues, FV, Hochman, B, Wood, VT, Simões, MJ, Juliano, Y, Ferreira, LM. Effects of lidocaine with epinephrine or with buffer on wound healing in rat skin. Wound Repair Regen 2011;19:223–8Google Scholar
35Doğan, N, Uçok, C, Korkmaz, C, Uçok, O, Karasu, HA. The effects of articaine hydrochloride on wound healing: an experimental study. J Oral Maxillofac Surg 2003;61:1467–70Google Scholar
36Waite, A, Gilliver, SC, Masterson, GR, Hardman, MJ, Ashcroft, GS. Clinically relevant doses of lidocaine and bupivacaine do not impair cutaneous wound healing in mice. Br J Anaesth 2010;104:768–73Google Scholar
37Isaacson, G. Tonsillectomy healing. Ann Otol Rhinol Laryngol 2012;121:645–9Google Scholar
38Lewis, SR, Nicholson, A, Cardwell, ME, Siviter, G, Smith, AF. Nonsteroidal anti-inflammatory drugs and perioperative bleeding in paediatric tonsillectomy. Cochrane Database Syst Rev 2013;(18):CD003591Google Scholar
39D'Souza, JN, Schmidt, RJ, Xie, L, Adelman, JP, Nardone, HC. Postoperative nonsteroidal anti-inflammatory drugs and risk of bleeding in pediatric intracapsular tonsillectomy. Int J Pediatr Otorhinolaryngol 2015;79:1472–6Google Scholar
40FDA Drug Safety Communication. Safety review update of codeine use in children; new Boxed Warning and Contraindication on use after tonsillectomy and/or adenoidectomy. In: https://www.fda.gov/downloads/Drugs/DrugSafety/UCM339116.pdf [20 February 2013]Google Scholar
41Ciszkowski, C, Madadi, P, Phillips, MS, Lauwers, AE, Koren, G. Codeine, ultrarapid-metabolism genotype, and postoperative death. N Engl J Med 2009;361:827–8Google Scholar
42Gunter, JB, Willging, JP, Myer, CM 3rd. Dexamethasone and postoperative bleeding after tonsillectomy in children. JAMA 2009;301:1765–6Google Scholar
43Steward, DL, Grisel, J, Meinzen-Derr, J. Steroids for improving recovery following tonsillectomy in children. Cochrane Database Syst Rev 2011;(10):CD003997Google Scholar
44Bellis, JR, Pirmohamed, M, Nunn, AJ, Loke, YK, De, S, Golder, S et al. Dexamethasone and haemorrhage risk in paediatric tonsillectomy: a systematic review and meta-analysis. Br J Anaesth 2014;113:2023–42Google Scholar
45Baugh, RF, Archer, SM, Mitchell, RB, Rosenfeld, RM, Amin, R, Burns, JJ et al. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg 2011;144:S130Google Scholar