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Parathyroid adenomas: pre-operative localization with ultrasound combined with fine-needle biopsy

Published online by Cambridge University Press:  29 June 2007

Tapani Tikkakoski ,
Lars-Eric Stenfors ,
Tapani Typpö ,
Pentti Lohela  and
Meeri Apaja-Sarkkinen
Tapani Tikkakoski*
Affiliation:
Departments of Radiology, Central Hospital of Keski-Pohjanmaa. Kokkola
Lars-Eric Stenfors
Affiliation:
Departments of Otolaryngology. Central Hospital of Keski-Pohjanmaa. Kokkola
Tapani Typpö
Affiliation:
Departments of Radiology, Central Hospital of Keski-Pohjanmaa. Kokkola
Pentti Lohela
Affiliation:
Departments of Radiology, Central Hospital of Keski-Pohjanmaa. Kokkola
Meeri Apaja-Sarkkinen
Affiliation:
The Department of Pathology, Oulu, Finland
*
Tapani Tikkakoski, M.D., Savikukonkuja 3 B, SF-67100 Kokkola, Finland
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Abstract

Sixteen patients with biochemically proven primary hyperparathyroidism (PHPT) underwent ultrasonography (US), fine-needle aspiration (FNA) for cytologic sampling (n = 9), or intact parathormone assay (n = 3) before operation (n = 15) in order to determine the accuracy of the methods. Pre-operative US was found sensitive (100 per cent), but two thyroid lesions were initially diagnosed as parathyroid tumours by US (i.e. false positives). Parathyroid cells were detected in six cytologic specimens, one sample was insufficient and another inconclusive, while one was diagnosed as thyroid tissue. Parathormone assay revealed a high hormone content in all three patients who underwent the procedure. We conclude that US is sufficiently sensitive to detect enlarged parathyroid tumours. Specificity can be improved by US-guided FNA for cytology or parathormone assay prior to neck exploration.

Keywords

Parathyroid neoplasmsUltrasonic diagnosisBiopsy, needle
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 6 , June 1993 , pp. 543 - 545
Copyright
Copyright © JLO (1984) Limited 1993

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