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Paradoxical long-term enhancement of distortion product otoacoustic emission amplitude after repeated exposure to moderate level, wide band noise in awake guinea pigs

Published online by Cambridge University Press:  16 July 2009

L Mei ,
Z-W Huang  and
Z-Z Tao
L Mei
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital, Wuhan University, China
Z-W Huang
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital, Wuhan University, China
Z-Z Tao*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital, Wuhan University, China
*
Address for correspondence: Dr Ze-Zhang Tao, Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital, Wuhan University, Wuhan 430060, China. Fax: +86 27 88043958 E-mail: [email protected]
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Abstract

Objective:

Hearing sensitivity usually diminishes with noise exposure. In the present study, we examined the effect of 93 dB(A) wide band noise on cochlear micromechanical sensitivity in awake guinea pigs.

Methods:

Animals were randomly assigned to groups receiving either single or repeated noise exposure. Distortion product otoacoustic emission amplitudes were recorded before, during and after noise exposure.

Results:

Ninety-three decibel(A) wide band noise reduced the distortion product otoacoustic emission amplitudes at all tested frequencies. The distortion product otoacoustic emission amplitudes for higher frequencies showed a permanent reduction, whereas those for lower frequencies showed a temporary reduction. Distortion product otoacoustic emission amplitudes for middle frequencies showed prolonged enhancement after repeated noise exposure.

Conclusion:

Our results suggest that (1) it is likely that there are intermediate stages between permanent threshold shift and temporary threshold shift, and (2) long-term enhancement of distortion product otoacoustic emission amplitudes may be an indication of tinnitus generation.

Keywords

NoiseOtoacoustic EmissionsHearing DisordersCochlea
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 10 , October 2009 , pp. 1090 - 1096
Copyright
Copyright © JLO (1984) Limited 2009

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References

1Kemp, DT. Stimulated acoustic emissions from within the human auditory system. J Acoust Soc Am 1978;64:1386–91CrossRefGoogle ScholarPubMed
2Yoshida, N, Liberman, MC. Sound conditioning reduces noise-induced permanent threshold shift in mice. Hear Res 2000;148:213–19CrossRefGoogle ScholarPubMed
3Wagner, W, Staud, I, Frank, G, Dammann, F, Plontke, S, Plinkert, PK. Noise in magnetic resonance imaging: no risk for sensorineural function but increased amplitude variability of otoacoustic emissions. Laryngoscope 2003;113:1216–23CrossRefGoogle ScholarPubMed
4Peng, JH, Tao, ZZ, Huang, ZW. Long-term sound conditioning increases distortion product otoacoustic emission amplitudes and decreases olivocochlear efferent reflex strength. Neuroreport 2007;18:1167–70CrossRefGoogle ScholarPubMed
5Oeken, J, Menz, D. Amplitude changes in distortion products of otoacoustic emissions after acute noise exposure [in German]. Laryngorhinootologie 1996;75:265–9CrossRefGoogle ScholarPubMed
6Kujawa, SG, Liberman, MC. Long-term sound conditioning enhances cochlear sensitivity. J Neurophysiol 1999;82:863–73CrossRefGoogle ScholarPubMed
7Cianfrone, G, Ingrosso, A, Altissimi, G, Ralli, G, Turchetta, R. DPOAE modifications induced by pure tone overstimulation in guinea pigs. Scand Audiol Suppl 1998;48:37–43Google ScholarPubMed
8Kirk, DL, Patuzzi, RB. Transient changes in cochlear potentials and DPOAEs after low-frequency tones: the ‘two-minute bounce’ revisited. Hear Res 1997;112:49–68CrossRefGoogle ScholarPubMed
9Huang, ZW, Luo, Y, Wu, Z, Tao, Z, Jones, RO, Zhao, HB. Paradoxical enhancement of active cochlear mechanics in long-term administration of salicylate. J Neurophysiol 2005;93:2053–61CrossRefGoogle ScholarPubMed
10Kim, DO, Leonard, G, Fallon, M, Bobbin, RP. Otoacoustic emissions and noise-induced hearing loss: human studies. In: Dancer, A, Henderson, D, Salvi, RJ, Hamernik, RP, eds. Noise-Induced Hearing Loss. St Louis: Mosby Year Book, 1992;476–88Google Scholar
11Kemp, DT. Cochlear echoes – implications for noise-induced hearing loss. In: Hamernik, RP, Henderson, D, Salvi, R, eds. New Perspectives in Noise-Induced Hearing Loss. New York: Raven Press, 1982;189–207Google Scholar
12Kemp, DT. Otoacoustic emissions, travelling waves and cochlear mechanisms. Hear Res 1986;22:95–104CrossRefGoogle ScholarPubMed
13Hirsh, IJ, Ward, WD. Recovery of the auditory threshold after strong acoustic stimulation. J Acoust Soc Am 1952;24:131–41CrossRefGoogle Scholar
14Yoshida, N, Kristiansen, A, Liberman, MC. Heat stress and protection from permanent acoustic injury in mice. J Neurosci 1999;19:10116–24CrossRefGoogle ScholarPubMed
15Murakoshi, M, Yoshida, N, Kitsunai, Y, Iida, K, Kumano, S, Suzuki, T et al. Effects of heat stress on Young's modulus of outer hair cells in mice. Brain Res 2006;1107:121–30CrossRefGoogle ScholarPubMed
16Wang, Y, Liberman, MC. Restraint stress and protection from acoustic injury in mice. Hear Res 2002;165:96–102CrossRefGoogle ScholarPubMed
17Raveh, E, Mount, RJ, Harrison, RV. Increased otoacoustic-emission amplitude secondary to cochlear lesions. J Otolaryngol 1998;27:354–60Google ScholarPubMed
18Kakigi, A, Hirakawa, H, Harel, N, Mount, RJ, Harrison, RV. Basal cochlear lesions result in increased amplitude of otoacoustic emissions. Audiol Neurootol 1998;3:361–72CrossRefGoogle ScholarPubMed
19Cevette, MJ, Drew, D, Webb, TM, Marion, MS. Cisplatin ototoxicity, increased DPOAE amplitudes, and magnesium deficiency. Distortion product otoacoustic emissions. J Am Acad Audiol 2000;11:323–9Google ScholarPubMed
20Yu, N, Zhu, ML, Johnson, B, Liu, YP, Jones, RO, Zhao, HB. Prestin up-regulation in chronic salicylate (aspirin) administration: an implication of functional dependence of prestin expression. Cell Mol Life Sci 2008;65:2407–18CrossRefGoogle ScholarPubMed
21Davis, B, Qiu, W, Hamernik, RP. Sensitivity of distortion product otoacoustic emissions in noise-exposed chinchillas. J Am Acad Audiol 2005;16:69–78Google ScholarPubMed
22Sutton, LA, Lonsbury-Martin, BL, Martin, GK, Whitehead, ML. Sensitivity of distortion-product otoacoustic emissions in humans to tonal over-exposure: time course of recovery and effects of lowering L2. Hear Res 1994;75:161–74CrossRefGoogle ScholarPubMed
23Gaskill, SA, Brown, AM. The behavior of the acoustic distortion product, 2f1-f2, from the human ear and its relation to auditory sensitivity. J Acoust Soc Am 1990;88:821–39CrossRefGoogle ScholarPubMed
24Kemp, DT. Physiologically active cochlear micromechanics: a source of tinnitus. In: Tinnitus, CIBA Foundation Symposium No. 85. London: Pitmans Medical, 1981;54–81CrossRefGoogle Scholar
25Cazals, Y, Horner, KC, Huang, ZW. Alterations in average spectrum of cochleoneural activity by long-term salicylate treatment in the guinea pig: a plausible index of tinnitus. J Neurophysiol 1998;80:2113–20CrossRefGoogle ScholarPubMed
26Janssen, T, Kummer, P, Arnold, W. Growth behavior of the 2 f1-f2 distortion product otoacoustic emission in tinnitus. J Acoust Soc Am 1998;103:3418–30CrossRefGoogle ScholarPubMed
27Hesse, G, Schaaf, H, Laubert, A. Specific findings in distortion product otoacoustic emissions and growth functions with chronic tinnitus. Int Tinnitus J 2005;11:6–13Google ScholarPubMed
28Henry, JA, Meikle, M, Gilbert, A. Audiometric correlates of tinnitus pitch: insights from the Tinnitus Data Registry. In: Hazell, J, ed. Proceedings of the Sixth International Tinnitus Seminar. The Tinnitus and Hyperacusis Center, London, 1999;51–7Google Scholar
29Konig, O, Schaette, R, Kempter, R, Gross, M. Course of hearing loss and occurrence of tinnitus. Hear Res 2006;221:59–64CrossRefGoogle ScholarPubMed
30Norena, A, Micheyl, C, Chery-Croze, S, Collet, L. Psychoacoustic characterization of the tinnitus spectrum: implications for the underlying mechanisms of tinnitus. Audiol Neurootol 2002;7:358–69CrossRefGoogle ScholarPubMed
31Roberts, LE, Moffat, G, Bosnyak, DJ. Residual inhibition functions in relation to tinnitus spectra and auditory threshold shift. Acta Otolaryngol Suppl 2006;556:27–33CrossRefGoogle Scholar
32Frank, G, Kösslo, M. The acoustic two-tone distortions 2f1-f2 and f2-f1 and their possible relation to changes in the operating point of the cochlear amplifier. Hear Res 1996;98:104–15CrossRefGoogle ScholarPubMed
33Arnold, DJ, Lonsbury-Martin, BL, Martin, GK. High-frequency hearing influences lower-frequency distortion-product otoacoustic emissions. Arch Otolaryngol Head Neck Surg 1999;125:215–22CrossRefGoogle ScholarPubMed