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Outcomes of definitive radiotherapy for early laryngeal cancer in terms of survival and patterns of failure

Published online by Cambridge University Press:  03 December 2019

M Adeel ,
M Faisal ,
A Rashid ,
S Rasheed ,
R Hussain ,
K I Malik ,
M Y Hameed  and
A Jamshed
M Adeel
Affiliation:
Surgical Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
M Faisal*
Affiliation:
Surgical Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
A Rashid
Affiliation:
Radiation Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
S Rasheed
Affiliation:
Radiation Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
R Hussain
Affiliation:
Surgical Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
K I Malik
Affiliation:
Surgical Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
M Y Hameed
Affiliation:
Rhodes College, Memphis, USA
A Jamshed
Affiliation:
Radiation Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
*
Author for correspondence: Dr Muhammad Faisal, Institute of Head and Neck Disease, Evangelisches Krankenhaus, Hans Sachs Gasse 10-12, Vienna1180, Austria E-mail: [email protected]
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Abstract

Background

Early laryngeal cancer treated with definitive radiotherapy or surgery has a high cure rate. This study evaluated the patterns of treatment failure and long-term results of early laryngeal cancers treated with definitive radiotherapy.

Method

From January 2002 to December 2014, a total of 242 patients with early-stage laryngeal cancers were treated with radical radiotherapy.

Results

All patients had squamous cell carcinoma of the larynx (92 per cent male and 8 per cent female). Median follow-up was 4.5 years. The majority of patients were smokers (57.4 per cent). Local failure was seen in 12.5 per cent of stage I patients and 22.8 per cent of stage II patients. The 5-year overall survival and disease specific survival were 84 per cent and 91 per cent, respectively.

Conclusion

In summary, radiotherapy is a suitable treatment modality for patients with early-stage laryngeal cancer, with an overall locoregional control rate of 84 per cent. Patients who fail radiotherapy may still undergo salvage laryngectomy.

Keywords

Laryngeal NeoplasmsHead And Neck Neoplasms
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 12 , December 2019 , pp. 1087 - 1091
Copyright
Copyright © JLO (1984) Limited, 2019

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Footnotes

Dr M Faisal takes responsibility for the integrity of the content of the paper

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