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Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion

Published online by Cambridge University Press:  17 August 2015

D Mel-Hennawi  and
M R Ahmed
D Mel-Hennawi
Affiliation:
Otolaryngology Unit, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
M R Ahmed*
Affiliation:
Otolaryngology Unit, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
*
Address for correspondence: Dr Mohamed Rifaat Ahmed, Otolaryngology Unit, Faculty of Medicine, Suez Canal University, Ismailia, Egypt Fax: +20 66 3415603 E-mail: [email protected]
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Abstract

Objective:

To compare the efficacy of two treatment regimens among Helicobacter pylori stool antigen positive children suffering from resistant otitis media with effusion.

Methods:

The study comprised 258 children with bilateral otitis media with effusion; 134 were positive for H pylori stool antigen, and were equally and randomly allocated to the control group or study group. The control group received standard otitis media with effusion therapy (amoxicillin and clavulanate), while the study group received standard H pylori triple therapy (clarithromycin, metronidazole and lansoprazole).

Results:

In the control group, there was a marked clinical response to treatment in 33 of the 67 children (49.3 per cent). In the study group, there was a marked response in a significantly higher number of children (46 out of 67, 68.7 per cent). The 124 H pylori stool antigen negative children not included in the 2 aforementioned groups received amoxicillin and clavulanate, and a marked response in symptoms was evident in 98 of these children (79 per cent).

Conclusion:

H pylori infection may lead to resistance to traditional otitis media with effusion treatment in some cases. H pylori eradication is associated with a high cure rate.

Keywords

Anti-Bacterial AgentsBacterial InfectionsOral Drug AdministrationCampylobacter PyloriOtitis Media
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 11 , November 2015 , pp. 1069 - 1072
Copyright
Copyright © JLO (1984) Limited 2015 

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