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Oncogenic osteomalacia in a patient with an ethmoid sinus tumour

Published online by Cambridge University Press:  11 December 2009

R Kurien ,
M T Manipadam  and
V Rupa
R Kurien
Affiliation:
Department of ENT, Christian Medical College, Vellore, Tamilnadu, India
M T Manipadam
Affiliation:
Department of Pathology, Christian Medical College, Vellore, Tamilnadu, India
V Rupa*
Affiliation:
Department of ENT, Christian Medical College, Vellore, Tamilnadu, India
*
Address for correspondence: Dr V Rupa, Department of ENT, Christian Medical College, Vellore, Tamilnadu, India 632004. Fax: +91 0416 2232035 E-mail: [email protected]
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Abstract

Objective:

To highlight the clinical presentation and management of a rare case of oncogenic osteomalacia due to an ethmoid sinus tumour.

Materials and methods:

We examined the case records of a 55-year-old man who presented with progressive fatigue, weakness and bone pain, and noted the clinical presentation, laboratory investigations, computed tomography findings, operative notes and follow-up details.

Conclusion:

Oncogenic osteomalacia secondary to a paranasal sinus neoplasm is a rare entity. The causative tumour is often occult and may be missed by routine clinical examination. This case report illustrates the appropriate pattern of evaluation and management to ensure a successful outcome.

Keywords

OsteomalaciaParanasal Sinus NeoplasmsEthmoid Sinuses
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 7 , July 2010 , pp. 799 - 803
Copyright
Copyright © JLO (1984) Limited 2009

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References

1Weidner, N, Santa Cruz, D. Phosphaturic mesenchymal tumors: a polymorphous group causing osteomalacia or rickets. Cancer 1987;59:1442–54Google Scholar
2Koriyama, N, Nishimoto, K, Kodama, T, Nakazaki, M, Kurona, Y, Yoshida, H et al. Oncogenic osteomalacia in a case with a maxillary sinus mesenchymal tumor. Am J Med Sci 2006;332:142–7CrossRefGoogle Scholar
3Weidner, N, Bar, RS, Weiss, D, Strottmann, MP. Neoplastic pathology of oncogenic osteomalacia/rickets. Cancer 1985;55:1691–705Google Scholar
4Folpe, AL, Fanburg-Smith, JC, Billings, SD, Bisceglia, M, Bertoni, F, Cho, JY et al. Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol 2004;28:1–30CrossRefGoogle Scholar
5Beech, TJ, Rokade, A, Gittoes, N, Johnson, AP. A haemangiopericytoma of the ethmoid sinus causing oncogenic osteomalacia: a case report and review of the literature. Int J Oral Maxillofac Surg 2007;36:956–8CrossRefGoogle ScholarPubMed
6Fuentealba, C, Pinto, D, Ballesteros, F, Pacheco, D, Boettiger, O, Soto, N et al. Oncogenic hypophosphatemic osteomalacia associated with a nasal hemangiopericytoma. J Clin Rheumatol 2003;9:373–9CrossRefGoogle ScholarPubMed
7Ungari, C, Rocchi, G, Rinna, C, Agrillo, A, Lattanzi, A, Pagnoni, M. Hypophosphaturic mesenchymal tumor of the ethmoid associated with oncogenic osteomalacia. J Craniofac Surg 2004;15:523–7Google Scholar
8Sandhu, FA, Martuza, RL. Craniofacial hemangiopericytoma associated with oncogenic osteomalacia: case report. J Neurooncol 2000;46:241–7CrossRefGoogle ScholarPubMed
9Gonzalez-Compta, X, Mañós-Pujol, M, Foglia-Fernandez, M, Peral, E, Condom, E, Claveguera, T et al. Oncogenic osteomalacia: case report and review of head and neck associated tumours. J Laryngol Otol 1998;112:389–92CrossRefGoogle ScholarPubMed
10Clunie, GPR, Fox, PE, Stamp, TCB. Four cases of acquired hypophosphataemic (‘oncogenic’) osteomalacia. Problems of diagnosis, treatment and long term management. Rheumatology 2000;39:1415–21CrossRefGoogle ScholarPubMed
11Weiss, D, Bar, RS, Weidner, N, Wener, M, Lee, F. Oncogenic osteomalacia: strange tumours in strange places. Postgrad Med J 1985;61:349–55CrossRefGoogle ScholarPubMed
12Ahn, JM, Kim, HJ, Cha, CM, Kim, J, Yim, SG, Kim, HJ. Oncogenic osteomalacia: induced by tumor, cured by surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:636–41Google Scholar
13Kaylie, DM, Jackson, CG, Gardner, EK. Oncogenic osteomalacia caused by phosphaturic mesenchymal tumor of the temporal bone. Otolaryngol Head Neck Surg 2006;135:653–4Google Scholar
14Schapira, D, Ben Izhak, O, Nachtigal, A, Burstein, A, Shalom, RB, Shagrawi, I et al. Tumor-induced osteomalacia. Semin Arthritis Rheum 1995;25:35–46CrossRefGoogle ScholarPubMed
15Oka, M, Kamo, T, Sasaki, E, Kaji, H, Nishizawa, H, Imanishi, Y et al. A case of phosphaturic mesenchymal tumour (mixed connective tissue variant) that developed in the subcutaneous tissue of a patient with oncogenic osteomalacia and produced fibroblast growth factor 23. Br J Dermatol 2007;157:198–200Google Scholar
16Jacob, JJ, Finny, P, Thomas, M, Thomas, N, John, M. Oncogenic, osteomalacia. J Assoc Physicians India 2007;55:231–3Google Scholar
17Nelson, AE, Mason, RS, Robinson, BG, Hogan, JJ, Martin, EA, Ahlström, H et al. Diagnosis of a patient with oncogenic osteomalacia using a phosphate uptake bioassay of serum and magnetic resonance imaging. Eur J Endocrinol 2001;145:469–76CrossRefGoogle ScholarPubMed
18Casari, S, Rossi, V, Varenna, M, Gasparini, M, Parafioriti, A, Failoni, S et al. A case of oncogenic osteomalacia detected by 111 In- pentetreotide total body scan. Clin Exp Rheumatol 2003;21:493–6Google Scholar
19Harish, S, Jurriaans, E, Jan, E, Sur, M, Colterjohn, N. Giant cell tumour of soft tissue causing oncogenic osteomalacia: report demonstrating the use of octreotide scintigraphy in tumour localization. Clin Radiol 2008;63:101–7Google Scholar
20Chua, SC, O'Connor, SR, Wong, WL, Ganatra, RH. Case report: solitary plasmacytoma of bone with oncogenic osteomalacia: recurrence of tumour confirmed by PET/CT. A case report with a review of the radiological literature. Br J Radiol 2008;8:110–14Google Scholar
21Wenig, BM. Atlas of Head and Neck Pathology: Neoplasms of the Nasal Cavity and Paranasal Sinuses, 2nd edn. New York: Saunders Elsevier, 2008;97–100Google Scholar