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Oncogenic impact of human papilloma virus in head and neck cancer

Published online by Cambridge University Press:  02 June 2010

C B Heffernan ,
J P O'Neill  and
C Timon
C B Heffernan*
Affiliation:
The Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin, Ireland
J P O'Neill
Affiliation:
The Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin, Ireland
C Timon
Affiliation:
The Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin, Ireland
*
Address for correspondence: Ms Colleen Heffernan, 172 Viewmount Park, Waterford, Ireland. E-mail: [email protected]
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Abstract

There is considerable debate within the literature about the significance of human papilloma virus in head and neck squamous cell carcinoma, and its potential influence on the prevention, diagnosis, grading, treatment and prognosis of these cancers. Cigarette smoking and alcohol consumption have traditionally been cited as the main risk factors for head and neck cancers. However, human papilloma virus, normally associated with cervical and other genital carcinomas, has emerged as a possible key aetiological factor in head and neck squamous cell carcinoma, especially oropharyngeal cancers. These cancers pose a significant financial burden on health resources and are increasing in incidence. The recent introduction of vaccines targeted against human papilloma virus types 16 and 18, to prevent cervical cancer, has highlighted the need for ongoing research into the importance of human papilloma virus in head and neck squamous cell carcinoma.

Keywords

Human Papilloma VirusHead And Neck NeoplasmsPharynx NeoplasmsSquamous Carcinoma
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 9 , September 2010 , pp. 941 - 944
Copyright
Copyright © JLO (1984) Limited 2010

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