Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-18T07:42:24.987Z Has data issue: false hasContentIssue false
  • English
  • Français

Olfactory bulb volume and olfactory sulcus depth in patients with Behçet's disease

Published online by Cambridge University Press:  18 December 2018

A Doğan ,
N Bayar Muluk ,
N Asal ,
M H Şahan ,
M Inal ,
Ö Gündüz  and
O K Arıkan
A Doğan
Affiliation:
Radiology Department, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey
N Bayar Muluk*
Affiliation:
Department of ENT, Faculty of Medicine, Kırıkkale University, Turkey
N Asal
Affiliation:
Department of Radiology, Faculty of Medicine, Kırıkkale University, Turkey
M H Şahan
Affiliation:
Department of Radiology, Faculty of Medicine, Kırıkkale University, Turkey
M Inal
Affiliation:
Department of Radiology, Faculty of Medicine, Kırıkkale University, Turkey
Ö Gündüz
Affiliation:
Department of Dermatology, Faculty of Medicine, Kırıkkale University, Turkey
O K Arıkan
Affiliation:
ENT Clinics, Adana Numune Training and Research Hospital, Adana, Turkey
*
Author for correspondence: Dr Nuray Bayar Muluk, Birlik Mahallesi, Zirvekent 2. Etap Sitesi, C-3 blok, No: 6-3/43, 06610 Çankaya/Ankara, Turkey E-mail: [email protected] Fax: +90 312 4964073
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

To investigate olfactory bulb volume and olfactory sulcus depth in patients with Behçet's disease, using magnetic resonance imaging.

Methods

Cranial magnetic resonance imaging scans of 27 adults with Behçet's disease (10 males and 17 females) and 27 healthy controls were examined. Olfactory bulb volume and olfactory sulcus depth were measured on coronal, T2-weighted, spectral pre-saturation with inversion recovery sequences.

Results

Bilateral olfactory bulb volume and right-sided olfactory sulcus depth were significantly lower in the Behçet's disease group than in the control group (p < 0.05). Left-sided olfactory sulcus depth increased with Behçet's disease duration. In both groups, olfactory bulb volume was significantly higher in the left than the right side. There were no gender differences for olfactory bulb volume and olfactory sulcus depth. Positive correlations were determined between right- and left-sided olfactory bulb volume values and between right- and left-sided olfactory sulcus depth values.

Conclusion

Behçet's disease may decrease olfactory functions, related to lower olfactory bulb volume and olfactory sulcus depth. The affected vascular system and possibly damaged neural system, nasal mucosal lesions, and prolonged nasal mucociliary clearance time may cause olfactory dysfunction. Patient follow up is recommended, with magnetic resonance imaging examinations of the olfactory system if necessary.

Keywords

Behçet DiseaseMagnetic Resonance ImagingOlfaction DisordersOlfactory BulbOlfactory Sulci
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 12 , December 2018 , pp. 1088 - 1092
Copyright
Copyright © JLO (1984) Limited, 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr N Bayar Muluk takes responsibility for the integrity of the content of the paper

References

1Akyol, L, Günbey, E, Karlı, R, Önem, S, Özgen, M, Sayarlıoğlu, M. Evaluation of olfactory function in Behçet's disease. Eur J Rheumatol 2016;3:153–6Google Scholar
2Landis, BN, Scheibe, M, Weber, C, Berger, R, Bramerson, A, Bende, M et al. Chemosensory interaction: acquired olfactory impairment is associated with decreased taste function. J Neurol 2010;257:1303–8Google Scholar
3Mattes, RD. Physiologic responses to sensory stimulation by food: nutritional implications. J Am Diet Assoc 1997;97:406–13Google Scholar
4Samuels, MH. Psychiatric and cognitive manifestations of hypothyroidism. Curr Opin Endocrinol Diabetes Obes 2014;21:377–83Google Scholar
5Doty, RL, Shaman, P, Dann, M. Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav 1984;32:489–502Google Scholar
6Wattendorf, E, Welge-Lussen, A, Fiedler, K, Bilecen, D, Wolfensberger, M, Fuhr, P et al. Olfactory impairment predicts brain atrophy in Parkinson's disease. J Neurosci 2009;29:15410–13Google Scholar
7Kim, JY, Lee, WY, Chung, EJ, Dhong, HJ. Analysis of olfactory function and the depth of olfactory sulcus in patients with Parkinson's disease. Mov Disord 2007;22:1563–6Google Scholar
8Held, P, Seitz, J, Frund, R, Nitz, WR, Haffke, T, Hees, H et al. MRI detection of olfactory bulb and tract. J Neuroradiol 2000;27:112–18Google Scholar
9Hummel, T, Witt, M, Reichmann, H, Welge-Luessen, A, Haehner, A. Immunohistochemical, volumetric, and functional neuroimaging studies in patients with idiopathic Parkinson's disease. J Neurol Sci 2010;289:119–22Google Scholar
10Wang, J, You, H, Liu, JF, Ni, DF, Zhang, ZX, Guan, J. Association of olfactory bulb volume and olfactory sulcus depth with olfactory function in patients with Parkinson disease. AJNR Am J Neuroradiol 2011;32:677–81Google Scholar
11Mueller, A, Abolmaali, ND, Hakimi, AR, Gloeckler, T, Herting, B, Reichmann, H et al. Olfactory bulb volumes in patients with idiopathic Parkinson's disease: a pilot study. J Neural Transm (Vienna) 2005;112:1363–70Google Scholar
12Chang, HK, Kim, SY. Survey and validation of the criteria for Behcet's disease recently used in Korea: a suggestion for modification of the International Study Group Criteria. J Korean Med Sci 2003;18:88–92Google Scholar
13Doğan, A, Bayar Muluk, N, Şahan, MH, Asal, N, Inal, M, Ergün, U. Olfactory bulbus volume and olfactory sulcus depth in migraine patients: an MRI evaluation. Eur Arch Otorhinolaryngol 2018;275:2005–11Google Scholar
14Duprez, TP, Rombaux, P. Imaging the olfactory tract (cranial nerve #1). Eur J Radiol 2010;74:288–98Google Scholar
15Buschhüter, D, Smitka, M, Puschmann, S, Gerber, JC, Witt, M, Abolmaali, ND et al. Correlation between olfactory bulb volume and olfactory function. Neuroimage 2008;42:498–502Google Scholar
16Webb, CJ, Moots, RJ, Swift, AC. Ear, nose and throat manifestations of Behçet's disease: a review. J Laryngol Otol 2008;122:1279–83Google Scholar
17Ozbay, I, Kucur, C, Temizturk, F, Ozkan, Y, Kahraman, C, Oghan, F. Assessment of nasal mucociliary activity in patients with Behçet's disease. J Laryngol Otol 2016;130:348–51Google Scholar
18Asai, K, Haruna, S, Otori, N, Yanagi, K, Fukami, M, Moriyama, H. Saccharin test of maxillary sinus mucociliary function after endoscopic sinus surgery. Laryngoscope 2000;110:117–22Google Scholar
19Lale, AM, Mason, JD, Jones, NS. Mucociliary transport and its assessment: a review. Clin Otolaryngol 1998;23:388–96Google Scholar
20Veyseller, B, Doğan, R, Ozücer, B, Aksoy, F, Meriç, A, Su, O et al. Olfactory function and nasal manifestations of Behçet's disease. Auris Nasus Larynx 2014;41:185–9Google Scholar
21Yousem, DM, Geckle, RJ, Bilker, WB, Kroger, H, Doty, RL. Posttraumatic smell loss: relationship of psychophysical tests and volumes of the olfactory bulbs and tracts and the temporal lobes. Acad Radiol 1999;6:264–72Google Scholar
22Mueller, A, Rodewald, A, Reden, J, Gerber, J, von Kummer, R, Hummel, T. Reduced olfactory bulb volume in post-traumatic and post-infectious olfactory dysfunction. Neuroreport 2005;16:475–8Google Scholar
23Rombaux, P, Mouraux, A, Bertrand, B, Nicolas, G, Duprez, T, Hummel, T. Olfactory function and olfactory bulb volume in patients with postinfectious loss. Laryngoscope 2006;116:436–9Google Scholar
24Thomann, PA, Dos Santos, V, Toro, P, Schönknecht, P, Essig, M, Schröder, J. Reduced olfactory bulb and tract volume in early Alzheimer's disease—a MRI study. Neurobiol Aging 2009;30:838–41Google Scholar
25Turetsky, BI, Moberg, PJ, Yousem, DM, Doty, RL, Arnold, SE, Gur, RE. Low olfactory bulb volume in first-degree relatives of patients with schizophrenia. Am J Psychiatry 2003;160:703–8Google Scholar
26Doğan, R, Ertaş, B, Özücer, B, Birday, E, Özturan, O, Veyseller, B. Olfactory dysfunction associated with neuro-Behçet disease. J Craniofac Surg 2017;28:e707–10Google Scholar