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A novel prognostic biomarker for recurrent aphthous stomatitis: calprotectin

Published online by Cambridge University Press:  09 July 2019

S Kayabasi  and
I Kuzucu
S Kayabasi*
Affiliation:
Department of ENT, Aksaray University Faculty of Medicine, Turkey
I Kuzucu
Affiliation:
Department of ENT, Aksaray University Faculty of Medicine, Turkey
*
Author for correspondence: Dr Serkan Kayabasi, Department of ENT, Faculty of Medicine, Aksaray University, Aksaray 68100, Turkey E-mail: [email protected] Fax: +90 382 2119100
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Abstract

Objective

This study aims to investigate whether there is a correlation between serum calprotectin concentration and oral ulcer activity in patients with active recurrent aphthous stomatitis.

Method

This prospective, cross-sectional, historical cohort study included 52 patients (26 with active lesions and 26 with inactive lesions) with recurrent aphthous stomatitis and 27 healthy volunteers. The relationship between the groups was statistically evaluated in terms of serum calprotectin level and other inflammatory parameters.

Results

The median calprotectin value of the active lesion group (80.5 ng/ml) was significantly higher than that of the control group (55.4 ng/ml, p = 0.002). Furthermore, the median calprotectin value of the active lesion group was significantly higher than that of the inactive lesion group (72.5 ng/ml, p = 0.017).

Conclusion

In patients with recurrent aphthous stomatitis and active ulcer lesions, the serum calprotectin value can be used as a reliable and robust prognostic marker for inflammation.

Keywords

StomatitisAphthousLeukocyte L1 Antigen ComplexInflammation
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 8 , August 2019 , pp. 691 - 695
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Dr S Kayabasi takes responsibility for the integrity of the content of the paper

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