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Neuroendocrine carcinomas of the larynx

Published online by Cambridge University Press:  29 June 2007

J. P. Logue ,
S. S. Banerjee ,
N. J. Slevin  and
S. Vasanthan
J. P. Logue*
Affiliation:
Department of Radiotherapy and Oncology, Christie Hospital, Manchester M20 9BX.
S. S. Banerjee
Affiliation:
Department of Histopathology, Christie Hospital, Manchester M20 9BX.
N. J. Slevin
Affiliation:
Department of Radiotherapy and Oncology, Christie Hospital, Manchester M20 9BX.
S. Vasanthan
Affiliation:
Department of Radiotherapy and Oncology, Christie Hospital, Manchester M20 9BX.
*
Dr J. P. Logue, Senior Registrar in Radiotherapy and Oncology, Christie Hospital, Wilmslow Road, Manchester M20 9BX.
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Abstract

The clinical and histopathological characteristics of seven cases of Moderately Differentiated Neuroendocrine Carcinomas (MDNEC) and two cases of Poorly Differentiated Neuroendocrine Carcinomas (PDNEC) have been reviewed. The tumours arose in the supraglottis of predominantly elderly men. Two cases had raised levels of urinary 5-hydroxy-indole-acetic acid at presentation but no case developed the carcinoid syndrome. PDNEC were histologically identical to the oat cell type carcinoma of the bronchus and were associated with an extremely aggressive clinical course with both patients dying of widespread metastases within one month of registration. MDNEC also metastasized frequently with four of seven cases dying with widespread disease. The tumours have previously been reported as not being radiosensitive; however three cases remain free of disease following biopsy and radiotherapy alone. The place of radiotherapy in the management of these tumours is discussed.

Keywords

Laryngeal neoplasmsCarcinomaneuroendocrine
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 12 , December 1991 , pp. 1031 - 1035
Copyright
Copyright © JLO (1984) Limited 1991

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