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Neuroendocrine carcinoma of the lip (Merkel Cell tumour) examined by electron microscopy and immunohistochemistry

Published online by Cambridge University Press:  29 June 2007

M. Boysen ,
P. Wetteland ,
T. Hovig  and
P. Brandtzaeg
M. Boysen*
Affiliation:
Departments of Otolaryngology, Institute of Pathology, University of Oslo, The National Hospital, (Rikshospitalet), N-0027, Oslo 1, Norway.
P. Wetteland
Affiliation:
Departments of Pathology, Institute of Pathology, University of Oslo, The National Hospital, (Rikshospitalet), N-0027, Oslo 1, Norway.
T. Hovig
Affiliation:
Laboratory for Electron MicroscopyInstitute of Pathology, University of Oslo, The National Hospital, (Rikshospitalet), N-0027, Oslo 1, Norway.
P. Brandtzaeg
Affiliation:
Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, The National Hospital, (Rikshospitalet), N-0027, Oslo 1, Norway.
*
M. Boysen, M.D., Department of Otolaryngology, Rikshospitalet, N-0027 Oslo 1, Norway.
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Abstract

A definite diagnosis of neuroendocrine carcinoma of the skin is seldom made on initial histological examination; the tumour is usually reported as a poorly differentiated or anaplastic carcinoma. By applying electron microscopy and immunohistochemistry, a correct diagnosis can be made. The ultrastructural examination shows dense-core membrane-bound granules, intermediate perinuclear filaments and desmosome-like junctions. Immunohistochemistry reveals positive staining for neuron-specific enolase and keratin, the latter in a characteristic paranuclear distribution. Confronted with an unusual clinical picture or indefinite histological diagnosis, tissue specimens should be secured for the above mentioned ancillary procedures.

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 5 , May 1989 , pp. 519 - 523
Copyright
Copyright © JLO (1984) Limited 1989

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