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Negative ANCA in Wegener's granulomatosis

Published online by Cambridge University Press:  29 June 2007

S. Carrie ,
K. B. Hughes  and
M. G. Watson
S. Carrie*
Affiliation:
Department of Otolaryngology, Doncaster Royal Infirmary, Doncaster.
K. B. Hughes
Affiliation:
Department of Otolaryngology, Doncaster Royal Infirmary, Doncaster.
M. G. Watson
Affiliation:
Department of Otolaryngology, Doncaster Royal Infirmary, Doncaster.
*
Mr Sean Carrie, Department of Otolaryngology, Doncaster Royal Infirmary, Armthorpe Road, Doncaster DN2 5LT. Fax: (0302) 761205.
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Abstract

Wegener's granulomatosis is a systemic vasculitis characterized by necrotizing granulomata and without treatment is associated with a poor prognosis. Antineutrophil cytoplasmic antibodies (ANCA) have proved to be a useful serological marker allowing for early diagnosis and treatment of this condition. We report two cases of patients who were ANCA-negative on presentation despite clinical suspicion of Wegener's granulomatosis. In both cases the patients developed a positive ANCA titre as the disease progressed.

Keywords

Antibodiesantineutrophil cytoplasmic (ANCA)Wegener's granulomatosis
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 108 , Issue 5 , May 1994 , pp. 420 - 422
Copyright
Copyright © JLO (1984) Limited 1994

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