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Nasal polyposis in patients with asthma and allergic rhinitis

Published online by Cambridge University Press:  12 June 2012

A Ahmadiafshar ,
H R Farjd ,
F Moezzi  and
N Mousavinasab
A Ahmadiafshar*
Affiliation:
Aayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Metabolic research center of Zanjan University of Medical Sciences, Zanjan, Iran
H R Farjd
Affiliation:
Aayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
F Moezzi
Affiliation:
Aayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
N Mousavinasab
Affiliation:
Metabolic research center of Zanjan University of Medical Sciences, Zanjan, Iran Associate professor of medical Statistics, Medical faculty, Zanjan University of Medical Sciences, Zanjan, Iran
*
Address for correspondence: Dr Akefeh Ahmadiafshar, Associate Professor of Pediatrics, Sub-specialist in Immunology and Allergy, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Fax: +98 241 4131340 E-mail: [email protected]
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Abstract

Objective:

This study aimed to determine the prevalence of nasal polyps in patients with allergic rhinitis and with asthma, and also to assess the impact of this condition on these disorders.

Study design:

Cross-sectional study.

Methods:

The presence of nasal polyps was assessed by rhinoscopy and endoscopic examination.

Results:

Nasal polyps were detected in 60 out of 250 patients (24 per cent) with documented asthma or allergic rhinitis. There was a statistically significant correlation between asthma severity and nasal polyposis prevalence (p = 0.007), but not between allergic rhinitis severity and nasal polyposis prevalence (p = 0.081). The prevalence of nasal polyps increased significantly with increasing patient age and rhinitis or asthma duration.

Conclusion:

The prevalence of nasal polyps in patients with allergic rhinitis or asthma was higher than previously reported. Given this high prevalence of nasal polyposis, nasal examination and concomitant treatment of this disorder are recommended.

Keywords

Nasal PolypsAsthmaAllergic RhinitisDiagnosis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 8 , August 2012 , pp. 780 - 783
Copyright
Copyright © JLO (1984) Limited 2012

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References

1 Mygind, N. Advances in the medical treatment of nasal polyps. Allergy 1999;54:12–16 CrossRefGoogle ScholarPubMed
2 Kramer, M, Rasp, G. Nasal polyposis: eosinophilia and interlukin-5. Allergy 1999;54:1–13 CrossRefGoogle Scholar
3 Hedman, J, Kaprio, J, Poussa, T, Nieminen, MM. Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol 1999;28:717–22CrossRefGoogle ScholarPubMed
4 Settipane, GA, Chafee, FH. Nasal polyps in asthma and rhinitis. A review of 6,037 patients. J Allergy Clin Immunol 1977;59:17–21 CrossRefGoogle Scholar
5 Klossek, JM, Neukirch, F, Pribil, C, Jankowski, R, Serrano, E, Chanal, I et al. Prevalence of nasal polyposis in France: a cross-sectional, case-control study. Allergy 2005;60:233–7CrossRefGoogle Scholar
6 Bateman, ND, Fahy, C, Woolford, TJ. Nasal polyps: still more questions than answers. J Laryngol Otol 2003;117:1–9 CrossRefGoogle ScholarPubMed
7 Mygind, NL, Lund, V. Intranasal corticosteroids for nasal polyposis: biological rationale, efficacy and safety. Treat Respir Med 2006;5:93–102 CrossRefGoogle ScholarPubMed
8 Kirtsreesakul, V. Nasal polyps: the relationship to allergy, sinonasal infection and histopathological type. J Med Assoc Thai 2004;87:277–82Google ScholarPubMed
9 Asero, R, Bottazzi, G. Nasal polyposis: a study of its association with airborne allergen hypersensitivity. Ann Allergy Asthma Immunol 2001;86:283–5CrossRefGoogle ScholarPubMed
10 Munoz del Castillo, F, Jurado-Ramos, A, Fernandez-Conde, BL, Soler, R, Barasona, MJ, Cantillo, E, et al. Allergenic profile of nasal polyposis. J Investig Allergol Clin Immunol 2009;19:110–16Google Scholar
11 Erbek, SS, Erbek, S, Topal, O, Cakmak, O. The role of allergy in the severity of nasal polyposis. Am J Rhinol 2007;21:686–90CrossRefGoogle ScholarPubMed
12 Bonfils, P, Avan, P, Malinvaud, D. Influence of allergy on the symptoms and treatment of nasal polyposis. Acta Otolaryngol 2006;126:839–44CrossRefGoogle ScholarPubMed
13 Bonfils, P, Malinvaud, D. Influence of allergy in patients with nasal polyposis after endoscopic sinus surgery. Acta Otolaryngol 2008;128:186–92CrossRefGoogle ScholarPubMed
14 Grigoreas, N, Vourdas, D, Petalas, K, Simeonidis, G, Demeroutis, I, Tsioulos, I. Nasal polyposis in patients with rhinitis and asthma. Allergy Asthma Proc 2002;23:169–74Google Scholar
15 Lourenco, O, Fonseca, AM, Taborda-Barata, L. Asthma is more frequently associated with non-allergic than allergic rhinitis in Portuguese patients. Rhinology 2009;47:207–13Google ScholarPubMed
16 Staikuniene, J, Vaitkus, S, Japertiene, LM, Ryskiene, S. Association of chronic rhinosinusitis with nasal polyps and asthma: clinical and radiological features, allergy and inflammation markers. Medicina (Kaunas) 2008;44:257–65CrossRefGoogle ScholarPubMed
17 Ceylan, E, Gencer, M, San, I. Nasal polyps and the severity of asthma. Respirology 2007;12:272–6CrossRefGoogle ScholarPubMed
18 National Heart Lung and Blood Institute. Guidelines for the Diagnosis and Management of Asthma. Bethesda, Maryland: National Heart Lung and Blood Institute, 2007 Google Scholar
19 Mullol, J, Valero, A, Alobid, J, Bartra, J, Navarro, AM, Chivato, T et al. Allergic Rhinitis and its Impact on Asthma update (ARIA 2008). The perspective from Spain. J Investig Allergol Clin Immunol 2008;18:327–34Google ScholarPubMed
20 Braunstahl, GJ, Fokkens, W. Nasal involvement in allergic asthma. Allergy 2003;58:1235–43CrossRefGoogle ScholarPubMed
21 Collins, MM, Pang, YT, Loughran, S, Wilson, JA. Environmental risk factors and gender in nasal polyposis. Clin Otolaryngol Allied Sci 2002;27:314–17CrossRefGoogle ScholarPubMed
22 Toledano Munoz, A, Herraiz Puchol, C, Navas Molinero, C, Garcia Simal, M, Navarro Cunchillo, M, Galindo Campillo, AN. Epidemiological study in patients with nasal polyposis [in Spanish]. Acta Otorrinolaringol Esp 2008;59:438–43Google ScholarPubMed
23 Bavbek, S, Celik, G, Ediger, D, Mungan, D, Sin, B, Demirel, YS et al. Severity and associated risk factors in adult asthma patients in Turkey. Ann Allergy Asthma Immunol 2000;85:134–9CrossRefGoogle ScholarPubMed
24 Mygind, N, Dahl, R, Bachert, C. Nasal polyposis, eosinophil dominated inflammation, and allergy. Thorax 2000;55(suppl 2):S79–83 CrossRefGoogle ScholarPubMed
25 Saitoh, T, Kusunoki, T, Yao, T, Kawano, K, Kojima, Y, Miyahara, K et al. Role of interleukin-17A in the eosinophil accumulation and mucosal remodeling in chronic rhinosinusitis with nasal polyps associated with asthma. Int Arch Allergy Immunol 2010;151:8–16 CrossRefGoogle ScholarPubMed
26 Tsicopoulos, A, Shimbara, A, de Nadai, P, Aldewachi, O, Lamblin, C, Lassalle, P et al. Involvement of IL-9 in the bronchial phenotype of patients with nasal polyposis. J Allergy Clin Immunol 2004;113:462–9CrossRefGoogle ScholarPubMed
27 Bachert, C, Claeys, SE, Tomassen, P, van Zele, T, Zhang, N. Rhinosinusitis and asthma: a link for asthma severity. Curr Allergy Asthma Rep 2010;10:194–201 CrossRefGoogle ScholarPubMed
28 Wise, SK, Ahn, CN, Schlosser, RJ. Localized immunoglobulin E expression in allergic rhinitis and nasal polyposis. Curr Opin Otolaryngol Head Neck Surg 2009;17:216–22CrossRefGoogle ScholarPubMed
29 Eghtedari, F, Cheraghzadeh, SR, Kashef, MA, Monabati, A, Kashef, S. Agreement rate of skin prick test with tissue eosinophil count in patients with nasal polyps. Iran J Allergy Asthma Immunol 2007;6:89–92 Google ScholarPubMed
30 Fan, GK, Wang, H, Takenaka, H. Eosinophil infiltration and activation in nasal polyposis. Acta Otolaryngol 2007;127:521–6CrossRefGoogle ScholarPubMed
31 Muñoz-Del-Castillo, F, Jurado-Ramos, A, Soler, R, Fernández-Conde, BL, Barasona, MJ, Cantillo, E et al. Fungal sensitization in nasal polyposis. J Investig Allergol Clin Immunol 2009;19:6–12 Google ScholarPubMed
32 Ahmadiafshar, A, Sepehri, S, Mousavinasab, S, Torabi, SZ. Recognition and frequency determination of common allergens in allergic patients of Zanjan City by skin prick test. Zanjan University of Medical Science Journal 2008;16:45–53 Google Scholar