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Nasal muco-ciliary clearance in snuff users

Published online by Cambridge University Press:  29 June 2007

Shashi Chetan*
Affiliation:
Karnataka, India
*
Dr Shashi Chetan, M.S., D.N.B., Lecturer, Dept. of Otolaryngology, Dr T. M. A. Pai Rotary Hospital (a unit of Kasturba Medical College), Bejai, Mangalore–575 004, Karnataka, India.

Abstract

The inhalation of nasal snuff (powdered tobacco) is widely prevalent in the Indian sub-continent. The effect of snuff application on the nasal mucociliary clearance (NMMC) time has been suspected but not demonstrated before. In this study the saccharin test is used to demonstrate the rate of nasal mucociliary clearance among chronic snuff users. The study demonstrates the depressant action of snuff on the nasal mucociliary clearance rate. A pharmacological and pathological basis for the depressant action of snuff on the NMMC rate is hypothesised on the basis of the results obtained.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 1993

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References

Auerbach, O., Stout, A.P., Hammond, E. C., Garfinkel, L. (1962) Changes in bronchial epithelium in relation to sex, age, residence, smoking and pneumonia. New England Journal of Medicine 267: 111119.CrossRefGoogle ScholarPubMed
Bhide, S. V., Kulkarni, J. R., Padma, P. R., Amonkar, A. J., Maru, G. B., Nair, U. J., Nair, J. (1989) Studies on tobacco specific nitrosamines and other carcinogenic agents in smokeless tobacco products. In Tobacco and Health: The Indian Scene (Sanghvi, L. D. and Notani, P. eds.) UICC Workshop, Tata Memorial Centre, Bombay, p 121131.Google Scholar
Dalhamn, T. (1966) Effect of cigarette smoke on ciliary activity. American Review of Respiratory Diseases, 93: 108114.Google ScholarPubMed
Ide, G.Suntzeff, V., Cowdry, E. V. (1959) A comparison of the histopathology of tracheal and bronchial epithelium of smokers and non-smokers. Cancer, 12: 473484.3.0.CO;2-Q>CrossRefGoogle Scholar
Jaffe, J. H. (1990) Drug addiction and drug abuse. In Goodman and Gilmans, The Pharmacological Basis of Therapeutics. 8th edition (Gilman, A. G., Rail, T. W., Nies, A. S., Taylor, P. eds.) Pergamon Press, New York, p 522573.Google Scholar
Kensler, C. J., Battista, S. P. (1963) Components of cigarette smoke with ciliary depressant activity. New England Journal of Medicine, 269: 11611166.CrossRefGoogle ScholarPubMed
Procter, D. F.Andersen, I., Lundqvist, G. (1979) Clearance of inhaled particles from the human nose. Archives of Internal Medicine, 131: 132139.CrossRefGoogle Scholar
Sanghvi, L. D. (1989) Tobacco related cancers. In Tobacco and Health: The Indian Scene (Sanghvi, L. D. and Notani, P. eds.) UICC Workshop, Tata Memorial Centre, Bombay, p 915.Google Scholar
Stanley, P., MacWilliam, L., Greenstone, M., Mackay, I., Cole, P. (1984) Efficacy of a saccharin test for screening to detect abnormal muco-ciliary clearance. British Journal for Diseases of Chest, 78: 6265.CrossRefGoogle Scholar