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Micro-ribonucleic acids in head and neck cancer: an introduction

Published online by Cambridge University Press:  24 April 2013

I Gunawardena ,
J Fitzgerald ,
A Morley ,
D J Hussey ,
C M Woods  and
A S Carney
I Gunawardena*
Affiliation:
Flinders ENT, Flinders Medical Centre and Flinders University, Bedford Park, South Australia, Australia
J Fitzgerald
Affiliation:
Flinders ENT, Flinders Medical Centre and Flinders University, Bedford Park, South Australia, Australia
A Morley
Affiliation:
Flinders ENT, Flinders Medical Centre and Flinders University, Bedford Park, South Australia, Australia
D J Hussey
Affiliation:
Department of Surgery, Flinders Medical Centre and Flinders University, Bedford Park, South Australia, Australia
C M Woods
Affiliation:
Flinders ENT, Flinders Medical Centre and Flinders University, Bedford Park, South Australia, Australia
A S Carney
Affiliation:
Flinders ENT, Flinders Medical Centre and Flinders University, Bedford Park, South Australia, Australia
*
Address for correspondence: Dr I Gunawardena, Flinders ENT, Department of Surgery, Flinders Medical Centre and Flinders University, Bedford Park, SA, Australia 5042 Fax: (+618) 82199908 E-mail: [email protected]
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Abstract

Background and methods:

Head and neck cancer is the sixth most common cancer worldwide. Advances in management have not greatly altered overall survival. Over the last decade, there have been significant scientific advances in our knowledge of cell cycle regulation and the complex oncogenic processes. MicroRNAs are small, non-coding RNAs which are integral to the regulation of gene expression and which play a part in carcinogenesis. The literature on the role of microRNA in head and neck cancer is reviewed.

Objective:

To introduce the role and significance of microRNAs in head and neck cancer.

Results:

The possibilities of incorporating microRNAs into clinical practice are discussed, including their potential role in diagnosis, prognosis, prediction of metastatic spread, therapy and tumour surveillance.

Conclusion:

Discoveries in expression profiling of microRNA in head and neck oncology promise advancements in the diagnosis, prognosis and therapy of these cancers.

Keywords

miRNAMarkers, BiochemicalCancer of Head And Neck
Type
Review Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Supplement S2 , July 2013 , pp. S2 - S7
Copyright
Copyright © JLO (1984) Limited 2013 

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References

1Jemal, A, Siegel, R, Ward, E, Hao, Y, Xu, J, Murray, T et al. Cancer statistics. CA Cancer J Clin 2008;58:71–96CrossRefGoogle ScholarPubMed
2Bonner, JA, Harari, PM, Giralt, J, Azarnia, N, Shin, DM, Cohen, RB et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006;354:567–78CrossRefGoogle ScholarPubMed
3Babu, JM, Prathibha, R, Jijith, VS, Hariharan, R, Pillai, MR. A miR-centric view of head and neck cancers. Biochim Biophys Acta 2011;1816:67–72Google ScholarPubMed
4Calin, GA. MicroRNAs and cancer: what we know and what we still have to learn. Genome Med 2009;1:78CrossRefGoogle ScholarPubMed
5Kim, VN, Nam, JW. Genomics of microRNA. Trends Genet 2006;22:165–73CrossRefGoogle ScholarPubMed
6Kim, VN. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 2005;6:376–85CrossRefGoogle ScholarPubMed
7Kim, VN, Han, J, Siomi, MC. Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol 2009;10:126–39CrossRefGoogle ScholarPubMed
8Gantier, MP, Sadler, AJ, Williams, BR. Fine-tuning of the innate immune response by microRNAs. Immunol Cell Biol 2007;85:458–62CrossRefGoogle ScholarPubMed
9Xiao, C, Rajewsky, K. MicroRNA control in the immune system: basic principles. Cell 2009;136:26–36CrossRefGoogle ScholarPubMed
10O'Connell, RM, Rao, DS, Chaudhuri, AA, Baltimore, D. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 2010;10:111–22CrossRefGoogle ScholarPubMed
11Ramdas, L, Giri, U, Ashorn, CL, Coombes, KR, El-Naggar, A, Ang, KK et al. miRNA expression profiles in head and neck squamous cell carcinoma and adjacent normal tissue. Head Neck 2009;31:642–54CrossRefGoogle ScholarPubMed
12Sulston, JE, Brenner, S. The DNA of Caenorhabditis elegans. Genetics 1974;77:95–104CrossRefGoogle ScholarPubMed
13Brenner, S. The genetics of Caenorhabditis elegans. Genetics 1974;77:71–94CrossRefGoogle ScholarPubMed
14Lee, RC, Feinbaum, RL, Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993;75:843–54CrossRefGoogle Scholar
15Wightman, B, Ha, I, Ruvkun, G, Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 1993;75:855–62CrossRefGoogle ScholarPubMed
16miRBase: the microRNA data base. In: http://miRBASE.org [18 November 2011]Google Scholar
17Rodriguez, A, Griffiths-Jones, S, Ashurst, JL, Bradley, A. Identification of mammalian microRNA host genes and transcription units. Genome Res 2004;14:1902–10CrossRefGoogle ScholarPubMed
18Gregory, RI, Yan, KP, Amuthan, G, Chendrimada, T, Doratotaj, B, Cooch, N et al. The Microprocessor complex mediates the genesis of microRNAs. Nature 2004;432:235–40CrossRefGoogle ScholarPubMed
19Carthew, RW, Sontheimer, EJ. Origins and mechanisms of miRNAs and siRNAs. Cell 2009;136:642–55CrossRefGoogle ScholarPubMed
20Gomes, CC, Gomez, RS. MicroRNA and oral cancer: future perspectives. Oral Oncol 2008;44:910–14CrossRefGoogle ScholarPubMed
21Lu, J, Getz, G, Miska, EA, Alvarez-Saavedra, E, Lamb, J, Peck, D et al. MicroRNA expression profiles classify human cancers. Nature 2005;435:834–8CrossRefGoogle ScholarPubMed
22Chen, HC, Chen, GH, Chen, YH, Liao, WL, Liu, CY, Chang, KP et al. MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma. Br J Cancer 2009;100:1002–11CrossRefGoogle ScholarPubMed
23Calin, GA, Dumitru, CD, Shimizu, M, Bichi, R, Zupo, S, Noch, E et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002;99:15524–9CrossRefGoogle ScholarPubMed
24Jiang, J, Lee, EJ, Gusev, Y, Schmittgen, TD. Real-time expression profiling of microRNA precursors in human cancer cell lines. Nucleic Acids Res 2005;33:5394–403CrossRefGoogle ScholarPubMed
25Chang, SS, Jiang, WW, Smith, I, Poeta, LM, Begum, S, Glazer, C et al. MicroRNA alterations in head and neck squamous cell carcinoma. Int J Cancer 2008;123:2791–7CrossRefGoogle ScholarPubMed
26Childs, G, Fazzari, M, Kung, G, Kawachi, N, Brandwein-Gensler, M, McLemore, M et al. Low-level expression of microRNAs let-7d and miR-205 are prognostic markers of head and neck squamous cell carcinoma. Am J Pathol 2009;174:736–45CrossRefGoogle ScholarPubMed
27Tran, N, McLean, T, Zhang, X, Zhao, CJ, Thomson, JM, O'Brien, C et al. MicroRNA expression profiles in head and neck cancer cell lines. Biochem Biophys Res Commun 2007;358:12–17CrossRefGoogle ScholarPubMed
28Fletcher, AM, Heaford, AC, Trask, DK. Detection of metastatic head and neck squamous cell carcinoma using the relative expression of tissue-specific mir-205. Transl Oncol 2008;1:202–8CrossRefGoogle ScholarPubMed
29Jakymiw, A, Patel, RS, Deming, N, Bhattacharyya, I, Shah, P, Lamont, RJ et al. Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells. Genes Chromosomes Cancer 2010;49:549–59CrossRefGoogle ScholarPubMed
30Wong, TS, Ho, WK, Chan, JY, Ng, RW, Wei, WI. Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res 2008;14:2588–92CrossRefGoogle ScholarPubMed
31Avissar, M, McClean, MD, Kelsey, KY, Marsit, CJ. MicroRNA expression in head and neck cancer associates with alcohol consumption and survival. Carcinogenesis 2009;30:2059–63CrossRefGoogle ScholarPubMed
32Hui, AB, Lenarduzzi, M, Krushel, T, Waldron, L, Pintilie, M, Shi, W et al. Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas. Clin Cancer Res 2010;16:1129–39CrossRefGoogle ScholarPubMed
33Avissar, M, Christensen, BC, Kelsey, KY, Marsit, CJ. MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma. Clin Cancer Res 2009;15:2850–5CrossRefGoogle ScholarPubMed
34Henson, BJ, Bhattacharjee, S, O'Dee, DM, Feingold, E, Gollin, SM. Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. Genes Chromosomes Cancer 2009;48:569–82CrossRefGoogle ScholarPubMed
35Long, XB, Sun, GB, Hu, S, Liang, GT, Wang, N, Zhang, XH et al. Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer. Oncol Rep 2009;22:1189–95Google ScholarPubMed
36Barker, EV, Cervigne, NK, Reis, PP, Goswami, RS, Xu, W, Weinreb, I et al. MicroRNA evaluation of unknown primary lesions in the head and neck. Mol Cancer 2009;23:127Google Scholar
37Liu, X, Wang, C, Chen, Z, Jin, Y, Wang, Y, Kolokythas, A et al. MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. Biochem J 2011;440:23–31CrossRefGoogle ScholarPubMed
38Jiang, L, Dai, Y, Liu, X, Wang, C, Wang, A, Chen, Z et al. Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma. Hum Genet 2011;129:189–97CrossRefGoogle ScholarPubMed
39Hurst, DR, Edmonds, MD, Welch, DR. Metastamir: the field of metastasis-regulatory microRNA is spreading. Cancer Res 2009;69:7495–8CrossRefGoogle ScholarPubMed
40HeNeCan miRs – A database of integrative information on head and neck cancer associated microRNAs. http://tarmir.rgcb.res.in/henecan [19 April 2012]Google Scholar
41Park, NJ, Zhou, H, Elashoff, D, Henson, BS, Kastratovic, DA, Abemayor, E et al. Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection. Clin Cancer Res 2009;15:5473–7CrossRefGoogle ScholarPubMed
42Liu, CJ, Kao, SY, Tu, HF, Tsai, MM, Chang, KW, Lin, SC. Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer. Oral Dis 2010;16:360–4CrossRefGoogle ScholarPubMed
43Wong, TS, Ho, WK, Chan, JY, Ng, RW, Wei, WI. Mature miR-184 and squamous cell carcinoma of the tongue. Scientific World Journal 2009;9:130–2CrossRefGoogle ScholarPubMed
44Bader, AG, Brown, D, Winkler, M. The promise of microRNA replacement therapy. Cancer Res 2010;70:7027–30CrossRefGoogle ScholarPubMed
45Krutzfeldt, J, Rajewsky, N, Braich, R, Rajeev, KG, Tuschi, T, Manoharan, M et al. Silencing of microRNAs in vivo with ‘antagomirs’. Nature 2005;438:685–9CrossRefGoogle ScholarPubMed
46Ebert, MS, Neilson, JR, Sharp, PA. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods 2007;4:721–6CrossRefGoogle ScholarPubMed
47MacDiarmid, JA, Madrid-Weiss, J, Amaro-Mugridge, NB, Phillips, L, Brahmbhatt, H. Bacterially-derived nanocells for tumor-targeted delivery of chemotherapeutics and cell cycle inhibitors. Cell Cycle 2007;6:2099–105CrossRefGoogle ScholarPubMed